scholarly journals Bioreactor Cultivation of Anatomically Shaped Human Bone Grafts

2013 ◽  
pp. 57-78 ◽  
Author(s):  
Joshua P. Temple ◽  
Keith Yeager ◽  
Sarindr Bhumiratana ◽  
Gordana Vunjak-Novakovic ◽  
Warren L. Grayson
Keyword(s):  
Bone Grafts ◽  
Human Bone ◽  
Bioreactor Cultivation

scholarly journals The influence of avascularity on the mechanical properties of human bone-patellar-tendon-bone grafts

2000 ◽  
Vol 82-B (7) ◽  
pp. 1059-1064 ◽  
Author(s):  
S. Rupp ◽  
R. Seil ◽  
D. Kohn ◽  
B. Müller
Keyword(s):  
Mechanical Properties ◽  
Patellar Tendon ◽  
Bone Grafts ◽  
Human Bone ◽  
Bone Patellar Tendon

Comparison of Bone Grafts From Various Donor Sites in Human Bone Specimens

2018 ◽  
Vol 29 (6) ◽  
pp. 1661-1665 ◽  
Author(s):  
Mohammad Kamal ◽  
Felix Gremse ◽  
Stefanie Rosenhain ◽  
Alexander K. Bartella ◽  
Frank Hölzle ◽  
...  
Keyword(s):  
Bone Grafts ◽  
Human Bone

Evaluation of Gamma Irradiated Human Bone in Nude Rats

2005 ◽  
Vol 288-289 ◽  
pp. 269-272
Author(s):  
Y. Yu ◽  
Jin Biao Chen ◽  
J.L. Yang ◽  
D.A.F. Morgan ◽  
W.R. Walsh
Keyword(s):  
Bone Formation ◽  
Gamma Irradiation ◽  
Soft Tissues ◽  
Bone Grafts ◽  
Human Bone ◽  
New Bone Formation ◽  
Nude Rats ◽  
Defect Area ◽  
Post Operation ◽  
Gamma Irradiated

Deep-frozen morselized human bone grafts showed osteoconductivity and osteoinductivity when implanted into tibial window defects of nude rats. The osteoconductivity was assessed by measuring the total area of newly formed bone bridged by the implanted bone grafts in the entire defect area. The osteoinductivity was evidenced by the presence of active osteoblast-like cells and new bone formation around the implanted bone grafts, which were surrounded by soft tissues distant from the host cortex. Gamma irradiation at the doses of 15 or 25 kGray reduced the osteoconductivity (ANOVA and LSD tests, p<0.05) at 3 weeks post operation. The 25 kGray group had a significantly lower level of new bone formation compared with the 0 and 15 kGray groups. The evidences of osteoinductivity were only noted in the 0 and 15 kGray groups. Our data indicate that 25 kGray gamma irradiation reduces the osteoconductive and osteoinductive properties of the morselized human bone graft.

Bone Regeneration with Cultured Human Bone Grafts

2000 ◽  
Vol 192-195 ◽  
pp. 475-478
Author(s):  
Takafumi Yoshikawa ◽  
Hajime Ohgushi ◽  
Toshimasa Uemura ◽  
Y. Ueda ◽  
Hideo Nakajima ◽  
...  
Keyword(s):  
Bone Regeneration ◽  
Bone Grafts ◽  
Human Bone

Early bone formation in human bone grafts treated with platelet-rich plasma: preliminary histomorphometric results

2007 ◽  
Vol 36 (12) ◽  
pp. 1164-1171 ◽  
Author(s):  
A. Thor ◽  
V. Franke-Stenport ◽  
C.B. Johansson ◽  
L. Rasmusson
Keyword(s):  
Bone Formation ◽  
Platelet Rich Plasma ◽  
Bone Grafts ◽  
Human Bone ◽  
Early Bone Formation

Osteogenic Differentiation and Immune Response of Human Bone-Marrow-Derived Mesenchymal Stem Cells on Injectable Calcium-Silicate-Based Bone Grafts

2010 ◽  
Vol 16 (7) ◽  
pp. 2343-2354 ◽  
Author(s):  
Shinn-Jyh Ding ◽  
Ming-You Shie ◽  
Takashi Hoshiba ◽  
Naoki Kawazoe ◽  
Guoping Chen ◽  
...  
Keyword(s):  
Stem Cells ◽  
Bone Marrow ◽  
Immune Response ◽  
Mesenchymal Stem Cells ◽  
Osteogenic Differentiation ◽  
Calcium Silicate ◽  
Bone Grafts ◽  
Human Bone ◽  
Human Bone Marrow

scholarly journals Concise Review: Personalized Human Bone Grafts for Reconstructing Head and Face

2011 ◽  
Vol 1 (1) ◽  
pp. 64-69 ◽  
Author(s):  
Sarindr Bhumiratana ◽  
Gordana Vunjak-Novakovic
Keyword(s):  
Bone Grafts ◽  
Human Bone ◽  
Concise Review

scholarly journals Evaluation of the Healing Potential of Demineralized Dentin Matrix Fixed with Recombinant Human Bone Morphogenetic Protein-2 in Bone Grafts

Materials ◽  
2017 ◽  
Vol 10 (9) ◽  
pp. 1049 ◽  
Author(s):  
Sang-Yun Kim ◽  
Young-Kyun Kim ◽  
Yeoung-Hyun Park ◽  
Joo-Cheol Park ◽  
Jeong-Kui Ku ◽  
...  
Keyword(s):  
Bone Morphogenetic Protein ◽  
Bone Grafts ◽  
Human Bone ◽  
Bone Morphogenetic Protein 2 ◽  
Morphogenetic Protein ◽  
Human Bone Morphogenetic Protein ◽  
Dentin Matrix ◽  
Demineralized Dentin Matrix ◽  
Recombinant Human Bone ◽  
Demineralized Dentin

scholarly journals High Hydrostatic Pressure for Disinfection of Bone Grafts and Biomaterials: An Experimental Study

2009 ◽  
Vol 3 (1) ◽  
pp. 1-7 ◽  
Author(s):  
Hans Gollwitzer ◽  
Wolfram Mittelmeier ◽  
Monika Brendle ◽  
Patrick Weber ◽  
Thomas Miethke ◽  
...  
Keyword(s):  
Hydrostatic Pressure ◽  
Bacterial Growth ◽  
High Hydrostatic Pressure ◽  
Chronic Osteomyelitis ◽  
Bone Grafts ◽  
Biological Properties ◽  
Human Bone ◽  
Bacterial Inactivation ◽  
Bacterial Survival

Background:Autoclaving, heat, irradiation or chemical detergents are used to disinfect autografts, allografts and biomaterials for tissue reconstruction. These methods are often associated with deterioration of mechanical, physical, and biological properties of the bone grafts and synthetic implants. High hydrostatic pressure has been proposed as a novel method preserving biomechanical and biological properties of bone, tendon and cartilage. This is the first study to assess the inactivation of clinically relevant bacteria on biomaterials and human bone by high hydrostatic pressure.Methods:Bacterial suspensions ofStaphylococcus aureus,Pseudomonas aeruginosaandEnterococcus faecium, implants covered with infected blood, human bone infectedin vitro, and biopsies of patients with chronic osteomyelitis were subjected to different protocols of high hydrostatic pressure up to 600 MPa. Bacterial survival after high hydrostatic pressure treatment was determined and compared with bacterial growth in untreated controls.Results:S. aureusandP. aeruginosain suspension were completely inactivated by high hydrostatic pressure (> 5log levels), whereasE. faeciumshowed barotolerance up to 600 MPa. Blood and adherence to metal implants did not significantly alter inactivation of bacteria, and complete disinfection was achieved with barotolerant bacteria (S. aureusandP. aeruginosa). However, osteoarthritic bone demonstrated a non-homogeneous baroprotective effect, with single bone samples resistant to treatment resulting in unaltered bacterial growth, and complete disinfection of artificially infected bone specimens was achieved in 66% forS. aureus, 60% forP. aeruginosaand 0% forE. faecium. Human bone samples of patients with chronic osteomyelitis could be completely disinfected in 2 of 37 cases.Conclusion:High hydrostatic pressure offers new perspectives for disinfection of sensitive biomaterials and bone grafts, and contamination by blood did not significantly affect bacterial inactivation rates. However, a significant baroprotective effect was demonstrated in bone. Effectiveness is currently limited to colonization and / or infection with barosensitive micro-organisms.

The fate of autogenous human bone grafts

1950 ◽  
Vol 3 ◽  
pp. 233-243 ◽  
Author(s):  
Lyndon A. Peer
Keyword(s):  
Bone Grafts ◽  
Human Bone
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