Neurobehavioral Effects from Developmental Methamphetamine Exposure

2015 ◽  
pp. 183-230 ◽  
Author(s):  
Sarah A. Jablonski ◽  
Michael T. Williams ◽  
Charles V. Vorhees
Keyword(s):  
Neurobehavioral Effects

Neurobehavioral Effects of Sodium Tungstate Exposure on Rats and Their Progeny

2007 ◽  
Author(s):  
S. M. McInturf ◽  
M. Y. V. Bekkedal ◽  
A. Olabisi ◽  
D. Arfsten ◽  
E. Wilfong ◽  
...  
Keyword(s):  
Sodium Tungstate ◽  
Neurobehavioral Effects

Neurobehavioral Effects of β-Escin

2019 ◽  
Vol 8 (1) ◽  
pp. 79-86
Author(s):  
Huda J. Waheed ◽  
Saad B. Nashtar ◽  
Ali I. Al-Gareeb ◽  
Hayder M. Al-Kuraishy
Keyword(s):  
Healthy Volunteers ◽  
Term Therapy ◽  
Horse Chestnut ◽  
Cortical Arousal ◽  
Short Term ◽  
Fusion Frequency ◽  
Insignificant Effect ◽  
Sensorimotor Reaction ◽  
Critical Fusion Frequency ◽  
Neurobehavioral Effects

Background: Aescin or β-escin is the main and active constituent of horse chestnut seed (Aesculus hippocastanum) used for the treatment of inflammatory edema, venous insufficiency and ischemic ulcerations. Aescin has many actions due to induction of endothelial nitric oxide and prostaglandin F2-α production moreover; aescin antagonizes the effect of histamine and 5HT at receptor levels. </P><P> Objective: The aim of the present study was to evaluate the neurobehavioral effects of aescin on normal healthy volunteers. </P><P> Method: A total number of 65 healthy participants with mean age of 21+1.1 years were recruited to study the effects of aescin on the neurobehavioral effects of normal healthy volunteers compared to placebo. The neurobehavioral effects were assessed by psychomotor performances and sensorimotor reaction, cortical arousal and central integrity processes and assessment of memory capacity. Results: Placebo produced insignificant amelioration of TRT and RRT p>0.05, with mild significant effect on MRT p=0.03. Aescin produced a significant effect in the amelioration of psychomotor performances and sensorimotor reaction p=0.0001. Regarding the differential effect of placebo and aescin on the cortical arousal and central integrity processes, placebo illustrated insignificant effect at p>0.05 whereas; aescin showed mild significant effect on Critical Fusion Frequency (CFFA) p<0.05 and highly significant effect on the other parameters p<0.01 except for critical-fusion frequency threshold when aescin illustrated insignificant effect at p>0.05. Aescin illustrated significant acceleration of ІІ-back WMA, ІІІ-back WMA and Second trial Short-Term Memory (STM) at p<0.01 compared to the placebo effect. Conclusion: Short-term therapy with aescin improves the neurobehavioral effects on healthy volunteers.

Persistent neurobehavioral effects of early postnatal domoic acid exposure in rats

2006 ◽  
Vol 28 (6) ◽  
pp. 673-680 ◽  
Author(s):  
Edward D. Levin ◽  
Wyki Gina Pang ◽  
Jerry Harrison ◽  
Paul Williams ◽  
Ann Petro ◽  
...  
Keyword(s):  
Domoic Acid ◽  
Acid Exposure ◽  
Neurobehavioral Effects

Neurobehavioral effects of lead in low level exposure studies

1986 ◽  
Vol 12 (1) ◽  
pp. 104
Author(s):  
C. Muñoz ◽  
K. Garbe ◽  
H. Lilienthal ◽  
G. Winneke
Keyword(s):  
Low Level ◽  
Neurobehavioral Effects

Neurobehavioral effects of dietary soy phytoestrogens

2002 ◽  
Vol 24 (1) ◽  
pp. 5-16 ◽  
Author(s):  
Edwin D Lephart ◽  
Timothy W West ◽  
K.Scott Weber ◽  
Reuben W Rhees ◽  
Kenneth D.R Setchell ◽  
...  
Keyword(s):  
Neurobehavioral Effects

Neurobehavioral effects of chronic low-dose vanadium administration in young male rats

2021 ◽  
pp. 113701
Author(s):  
Amanda Dyer ◽  
Maxine De Butte
Keyword(s):  
Low Dose ◽  
Young Male ◽  
Male Rats ◽  
Neurobehavioral Effects

Neurobehavioral effects of bisphenol S exposure in early life stages of zebrafish larvae (Danio rerio)

Chemosphere ◽  
2019 ◽  
Vol 217 ◽  
pp. 629-635 ◽  
Author(s):  
Jie Gu ◽  
Jiayao Zhang ◽  
Yaoyao Chen ◽  
Hongye Wang ◽  
Min Guo ◽  
...  
Keyword(s):  
Danio Rerio ◽  
Early Life ◽  
Life Stages ◽  
Early Life Stages ◽  
Bisphenol S ◽  
Zebrafish Larvae ◽  
Neurobehavioral Effects

scholarly journals Lack of Neuropathological Changes in Rats Administered Tedizolid Phosphate for Nine Months

2014 ◽  
Vol 59 (1) ◽  
pp. 475-481 ◽  
Author(s):  
Michael J. Schlosser ◽  
Hiromi Hosako ◽  
Ann Radovsky ◽  
Mark T. Butt ◽  
Dragomir Draganov ◽  
...  
Keyword(s):  
Body Weight ◽  
Optic Nerve ◽  
Body Weight Gain ◽  
Maximum Tolerated Dose ◽  
High Dose ◽  
Once Daily ◽  
Clinical Observations ◽  
Activity Measures ◽  
Dose Levels ◽  
Neurobehavioral Effects

ABSTRACTTedizolid, a novel oxazolidinone antibacterial, was administered to Long Evans rats by oral gavage once daily for up to 9 months at doses near the maximum tolerated dose (MTD) to evaluate for potential neurotoxicity. Mean plasma exposures of tedizolid at the low-, medium-, and high-dose levels (7.5, 15, and 30 mg/kg of body weight/day for males; 2.5, 5, and 10 mg/kg/day for females) were similar between males and females and were 1.8-, 3.9-, and 8.0-fold greater than exposures in patients at the therapeutic dose (200 mg once daily). Evaluated endpoints included survival, clinical observations, body weight, and food consumption. At 1, 3, 6, and 9 months, ophthalmic examinations, functional observational batteries, and locomotor activity measures were conducted, brain weights/sizes were recorded, and perfusion-fixed tissues were collected from 12 rats/sex/group/time point. A detailed morphological assessment was conducted on brain, eyes, optic nerve/tract, spinal cord, peripheral nerves (includes sciatic, sural, tibial, peroneal, trigeminal), and skeletal muscle. At the end of 9 months, less body weight gain was seen in high-dose males (−6.7%) and females (−5.8%) compared with that seen in controls. There were no tedizolid-related adverse neurobehavioral effects or tedizolid-related histopathologic changes in the central/peripheral nervous systems, including the optic nerve. Results of this study indicate that tedizolid was not neurotoxic when administered long term to pigmented rats at doses near the MTD, which were up to 8-fold higher than the human therapeutic exposure.

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