Regulation of Adaptive Immunity by Cells of the Innate Immune System: Bone Marrow Natural Killer Cells Inhibit T Cell Proliferation

2007 ◽  
pp. 113-120 ◽  
Author(s):  
Prachi P. Trivedi ◽  
Taba K. Amouzegar ◽  
Paul C. Roberts ◽  
Norbert A. Wolf ◽  
Robert H. Swanborg
Keyword(s):  
Bone Marrow ◽  
Cell Proliferation ◽  
Immune System ◽  
T Cell ◽  
Natural Killer Cells ◽  
Natural Killer ◽  
Adaptive Immunity ◽  
Innate Immune System ◽  
T Cell Proliferation ◽  
Killer Cells

Characterization of a subset of bone marrow-derived natural killer cells that regulates T cell activation in rats

2008 ◽  
Vol 83 (5) ◽  
pp. 1128-1135 ◽  
Author(s):  
Taba Kheradmand ◽  
Prachi P. Trivedi ◽  
Norbert A. Wolf ◽  
Paul C. Roberts ◽  
Robert H. Swanborg
Keyword(s):  
Bone Marrow ◽  
T Cell ◽  
Natural Killer Cells ◽  
Natural Killer ◽  
T Cell Activation ◽  
Cell Activation ◽  
Killer Cells

T cell– and B cell–independent adaptive immunity mediated by natural killer cells

2006 ◽  
Vol 7 (5) ◽  
pp. 507-516 ◽  
Author(s):  
Jacqueline G O'Leary ◽  
Mahmoud Goodarzi ◽  
Danielle L Drayton ◽  
Ulrich H von Andrian
Keyword(s):  
T Cell ◽  
Natural Killer Cells ◽  
B Cell ◽  
Natural Killer ◽  
Adaptive Immunity ◽  
Killer Cells

Skeletal unloading causes organ-specific changes in immune cell responses

1993 ◽  
Vol 75 (6) ◽  
pp. 2734-2739 ◽  
Author(s):  
J. W. Armstrong ◽  
K. A. Nelson ◽  
S. J. Simske ◽  
M. W. Luttges ◽  
J. J. Iandolo ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Cell Proliferation ◽  
Immune System ◽  
T Cell ◽  
Lymph Nodes ◽  
Immune Cell ◽  
Killer Cell ◽  
T Cell Proliferation ◽  
Skeletal Unloading ◽  
Natural Killer Cell Cytotoxicity

The effects of skeletal unloading using antiorthostatic tail suspension on the mouse immune system are tissue specific. This phenomenon was demonstrated by analyzing cells from the lymph nodes, spleen, and bone marrow. Phytohemagglutinin-induced T-cell proliferation was depressed in lymph nodes after 11 days of antiorthostatic suspension. In contrast, splenic T-cell proliferation in response to phytohemagglutinin was enhanced. Splenic natural killer cell cytotoxicity was unchanged after suspension, which demonstrated the organ- and cell-specific effects of skeletal unloading. Whereas antiorthostatic suspension induced minimal changes in bone, there was a significant depression in the number of macrophage precursors in the bone marrow. Overall, skeletally unloaded animals had slightly higher blood corticosterone levels than did control animals; however, it did not appear to be responsible for the observed changes. In conclusion, skeletal unloading produces organ- and cell-specific changes in the murine immune system rather than a generalized immunosuppression.

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