The Insulin Resistance Syndrome: Concept and Therapeutic Approaches

2007 ◽  
pp. 19-30 ◽  
Author(s):  
Gerald M. Reaven
Keyword(s):  
Insulin Resistance ◽  
Insulin Resistance Syndrome ◽  
Therapeutic Approaches

scholarly journals The Mechanistic and Pathophysiological Role of Adiponectin and Resistin Towards Regulation of Food Intake and Appetite in Cardiovascular Associated Risk Factor of Metabolic Syndrome

2021 ◽  
Author(s):  
Mimie Noratiqah Jumli ◽  
Muhammad Ilyas Nadeem
Keyword(s):  
Insulin Resistance ◽  
Metabolic Syndrome ◽  
Food Intake ◽  
Urban Population ◽  
Insulin Resistance Syndrome ◽  
Mediating Effect ◽  
Syndrome X ◽  
Therapeutic Approaches ◽  
Pathophysiological Role

Insulin resistance syndrome or syndrome X is also known as metabolic syndrome (MetS). It is an emerging problem globally with the surge of increasing prevalence among urban population of developing countries. The etiology of pathophysiology of metabolic syndrome includes the inflammatory pathways of insulin resistance, deregulated appetite, diet-induced, inflammation-induced obesity, and cardiovascular diseases (CVD). Adipose tissue is an endocrine organ that secrets adipokines like adiponectin and resistin during physiological and pathological states. Moreover, the adipokines associated with diet-induced and inflammation-induced obesity have secondary deteriorating effects on cardiovascular system. Although, the adiponectin and resistin were potentially found in regulating food intake and appetite but their mediating effect on pathophysiology of CVD still needs future investigations. However, the prior studies reported the association of adiponectin and resistin levels with CVD complications related to food intake but still there is need to understand its multifactorial heterogeneity. Therefore, literature suggests figuring out potential target mechanistic and therapeutic approaches of adiponectin and resistin hormone towards food intake and appetite involvement in metabolic syndrome and CVD.

HFE genotype and the insulin resistance syndrome among subjects with iron overload

2001 ◽  
Vol 120 (5) ◽  
pp. A565-A565
Author(s):  
J TALWALKAR ◽  
H TORGERSON ◽  
D BRANDHAGEN
Keyword(s):  
Insulin Resistance ◽  
Iron Overload ◽  
Insulin Resistance Syndrome

Features of insulin-resistance syndrome in men from French Caribbean Islands. The Telecom Study

Diabetes ◽  
1992 ◽  
Vol 41 (11) ◽  
pp. 1385-1389 ◽  
Author(s):  
A. Fontbonne ◽  
L. Papoz ◽  
E. Eschwege ◽  
M. Roger ◽  
M. Saint-Paul ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Insulin Resistance Syndrome ◽  
French Caribbean ◽  
Caribbean Islands

Some Coronary Risk Factors Related to the Insulin Resistance Syndrome and Treatment With Gemfibrozil

Circulation ◽  
1995 ◽  
Vol 92 (7) ◽  
pp. 1779-1785 ◽  
Author(s):  
Leena Tenkanen ◽  
Matti Mänttäri ◽  
Vesa Manninen
Keyword(s):  
Risk Factors ◽  
Insulin Resistance ◽  
Insulin Resistance Syndrome ◽  
Coronary Risk Factors ◽  
Coronary Risk

scholarly journals The 1st World Congress on the Insulin Resistance Syndrome

Diabetes Care ◽  
2004 ◽  
Vol 27 (2) ◽  
pp. 602-609 ◽  
Author(s):  
Z. T. Bloomgarden
Keyword(s):  
Insulin Resistance ◽  
Insulin Resistance Syndrome ◽  
World Congress

scholarly journals Interaction of physical activity and diet: implications for insulin-glucose dynamics

1999 ◽  
Vol 2 (3a) ◽  
pp. 363-368 ◽  
Author(s):  
Jean-Jacques Grimm
Keyword(s):  
Insulin Resistance ◽  
Cardiovascular Risk ◽  
Fatty Acid ◽  
Glycogen Synthase ◽  
Insulin Resistance Syndrome ◽  
Low Fat ◽  
Exercise Interventions ◽  
High Carbohydrate ◽  
Fat Diets

AbstractIn Western countries 25–35% of the population have insulin resistance syndrome characteristics.The defects most likely to explain the insulin resistance of the insulin resistance syndrome include: 1) the glucose transport system of skeletal muscle (GLUT-4) and its different signalling proteins and enzymes; 2) glucose phosphorylation by hexokinase; 3) glycogen synthase activity and 4) competition between glucose and fatty acid oxidation (glucose-fatty acid cycle).High carbohydrate/low fat diets deteriorate insulin sensitivity on the short term. Howewer, on the long term, high fat/low carbohydrate diets have a lower satiating power, induce low leptin levels and eventually lead to higher energy consumption, obesity and more insulin resistance. Moderately high-carbohydrate (45–55% of the daily calories)/low-fat diets seem to be a good choice with regard to the prevention of diabetes and cardiovascular risk factors as far as the carbohydrates are rich in fibers.Long-term interventions with regular exercise programs show a 1/3 decrease in the appearance of overt diabetes in glucose intolerant subjects. Furthermore, diet and exercise interventions "normalise" the mortality rate of patients with impared glucose tolerance.Therefore, moderately high carbohydrate/low fat diets are most likely to prevent obesity and type 2 diabetes. Triglycerides should be monitored and, in some cases, a part of the carbohydrates could be replaced by fat rich in monounsaturated fatty acids. However, total caloric intake is of utmost importance, as weight gain is the major determinant for the onset of insulin resistance and glucose intolerance.Regular (when possible daily) exercise, decreases cardiovascular risk. With regard to insulin resistance, resistance training seems to offer some advantages over aerobic endurance activities.

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