Use of SPIOs for Clinical Liver Imaging

2007 ◽  
pp. 41-61
Author(s):  
Akihiro Tanimoto
Keyword(s):  
Liver Imaging

Clinical Significance of Lung Uptake in Liver Scanning

1986 ◽  
Vol 25 (01) ◽  
pp. 15-18 ◽  
Author(s):  
M. Luostarinen ◽  
M Vorne ◽  
T. Lantto
Keyword(s):  
Clinical Significance ◽  
Final Diagnosis ◽  
Reticuloendothelial System ◽  
Liver Imaging ◽  
Lung Uptake ◽  
Benign Diseases ◽  
Number Of Patients ◽  
Liver Image ◽  
Liver Scanning ◽  
Stimulation Of

Summary 99mTc tin colloid accumulated in the lungs in 102 patients during liver imaging both in malignant and benign diseases. The percentage of neoplastic diseases increased when the lung uptake became greater and only patients with malignant final diagnosis had marked lung uptake. Abnormal liver image was seen only in 23%, which disagrees highly with some earlier findings on a rather small number of patients. The cause of increased lung uptake was suggested to be the activation of the reticuloendothelial system (RES) by disease. The activation of the RES was stronger in malignant than in benign diseases. Some type of regional stimulation of the RES was suggested as being due to the location of the disease and both malignant and benign diseases of the chest region stimulated the pulmonary part of the RES more than other parts of the RES.

Functional Liver Imaging Score derived from gadoxetic acid-enhanced MRI predicts outcomes in patients with chronic liver disease

2019 ◽  
Author(s):  
M Mandorfer ◽  
N Bastati ◽  
L Beer ◽  
S Pötter-Lang ◽  
D Tamandl ◽  
...  
Keyword(s):  
Liver Disease ◽  
Chronic Liver Disease ◽  
Chronic Liver ◽  
Gadoxetic Acid ◽  
Liver Imaging ◽  
Enhanced Mri

scholarly journals In vivo tumour imaging employing regional delivery of novel gallium radiolabelled polymer composites

2021 ◽  
Vol 25 (1) ◽  
Author(s):  
Ross W. Stephens ◽  
Gregory D. Tredwell ◽  
Jessica L. Bell ◽  
Karen J. Knox ◽  
Lee A. Philip ◽  
...  
Keyword(s):  
Normal Liver ◽  
Ct Imaging ◽  
Liver Imaging ◽  
Polymer Microspheres ◽  
Tumour Imaging ◽  
Planar Imaging ◽  
Rabbit Lung ◽  
Vitro Binding

Abstract Background Understanding the regional vascular delivery of particles to tumour sites is a prerequisite for developing new diagnostic and therapeutic composites for treatment of oncology patients. We describe a novel imageable 67Ga-radiolabelled polymer composite that is biocompatible in an animal tumour model and can be used for preclinical imaging investigations of the transit of different sized particles through arterial networks of normal and tumour-bearing organs. Results Radiolabelling of polymer microspheres with 67Ga was achieved using a simple mix and wash method, with tannic acid as an immobilising agent. Final in vitro binding yields after autoclaving averaged 94.7%. In vivo stability of the composite was demonstrated in New Zealand white rabbits by intravenous administration, and intrahepatic artery instillations were made in normal and VX2 tumour implanted rabbit livers. Stability of radiolabel was sufficient for rabbit lung and liver imaging over at least 3 hours and 1 hour respectively, with lung retention of radiolabel over 91%, and retention in both normal and VX2 implanted livers of over 95%. SPECT-CT imaging of anaesthetised animals and planar imaging of excised livers showed visible accumulation of radiolabel in tumours. Importantly, microsphere administration and complete liver dispersal was more easily achieved with 8 μm diameter MS than with 30 μm MS, and the smaller microspheres provided more distinct and localised tumour imaging. Conclusion This method of producing 67Ga-radiolabelled polymer microspheres is suitable for SPECT-CT imaging of the regional vascular delivery of microspheres to tumour sites in animal models. Sharper distinction of model tumours from normal liver was obtained with smaller MS, and tumour resolution may be further improved by the use of 68Ga instead of 67Ga, to enable PET imaging.

scholarly journals Dual-Energy Computed Tomography of the Liver: Uses in Clinical Practices and Applications

Diagnostics ◽  
2021 ◽  
Vol 11 (2) ◽  
pp. 161
Author(s):  
Masakatsu Tsurusaki ◽  
Keitaro Sofue ◽  
Masatoshi Hori ◽  
Kosuke Sasaki ◽  
Kazunari Ishii ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Liver Tumors ◽  
Energy Levels ◽  
Ct Scanning ◽  
Dual Energy ◽  
Liver Imaging ◽  
X Rays ◽  
Clinical Practices ◽  
Dual Energy Computed Tomography ◽  
Noise Ratio

Dual-energy computed tomography (DECT) is an imaging technique based on data acquisition at two different energy settings. Recent advances in CT have allowed data acquisitions and simultaneous analyses of X-rays at two energy levels, and have resulted in novel developments in the field of abdominal imaging. The use of low and high X-ray tube voltages in DECT provide fused images that improve the detection of liver tumors owing to the higher contrast-to-noise ratio (CNR) of the tumor compared with the liver. The use of contrast agents in CT scanning improves image quality by enhancing the CNR and signal-to-noise ratio while reducing beam-hardening artifacts. DECT can improve detection and characterization of hepatic abnormalities, including mass lesions. The technique can also be used for the diagnosis of steatosis and iron overload. This article reviews and illustrates the different applications of DECT in liver imaging.

scholarly journals Unexpected liver imaging during severe COVID-19 infection

2021 ◽  
pp. flgastro-2021-101840
Author(s):  
Francesca D'errico ◽  
Sreelakshmi Kotha ◽  
Terry Wong ◽  
Philip Berry
Keyword(s):  
Liver Imaging

Liver Imaging Reporting and Data System

2018 ◽  
Vol 42 (1) ◽  
pp. 155-161 ◽  
Author(s):  
Victoria Chernyak ◽  
Milana Flusberg ◽  
Amy Law ◽  
Mariya Kobi ◽  
Viktoriya Paroder ◽  
...  
Keyword(s):  
Data System ◽  
Liver Imaging

scholarly journals Imaging Medullary Thyroid Carcinoma with Persistent Elevated Calcitonin Levels

2007 ◽  
Vol 92 (11) ◽  
pp. 4185-4190 ◽  
Author(s):  
Anne Laure Giraudet ◽  
Daniel Vanel ◽  
Sophie Leboulleux ◽  
Anne Aupérin ◽  
Clarisse Dromain ◽  
...  
Keyword(s):  
Thyroid Carcinoma ◽  
Medullary Thyroid Carcinoma ◽  
Bone Scintigraphy ◽  
Axial Skeleton ◽  
Whole Body ◽  
Liver Imaging ◽  
Calcitonin Level ◽  
Medullary Thyroid ◽  
Positron Emission ◽  
Work Up

Abstract Purpose: Because calcitonin level remains elevated after initial treatment in many medullary thyroid carcinoma (MTC) patients without evidence of disease in the usual imaging work-up, there is a need to define optimal imaging procedures. Patients and Methods: Fifty-five consecutive elevated calcitonin level MTC patients were enrolled to undergo neck and abdomen ultrasonography (US); neck, chest, and abdomen spiral computed tomography (CT); liver and whole-body magnetic resonance imaging (MRI); bone scintigraphy; and 2-[fluorine-18]fluoro-2-deoxy-d-glucose (FDG) positron emission tomography (PET)/CT scan (PET). Results: Fifty patients underwent neck US, CT, and PET, and neck recurrence was demonstrated in 56, 42, and 32%, respectively. Lung and mediastinum lymph node metastases in the 55 patients were demonstrated in 35 and 31% by CT and in 15 and 20% by PET. Liver imaging with MRI, CT, US, and PET in 41 patients showed liver in 49, 44, 41, and 27% patients, respectively. Bone metastases in 55 patients were demonstrated in 35% by PET, 40% by bone scintigraphy, and 40% by MRI; bone scintigraphy was complementary with MRI for axial lesions but superior for the detection of peripheral lesions. Ten patients had no imaged tumor site despite elevated calcitonin level (median 196 pg/ml; range 39–816). FDG uptake in neoplastic foci was higher in progressive patients but with a considerable overlap with stable ones. Conclusion: The most efficient imaging work-up for depicting MTC tumor sites would consist of a neck US, chest CT, liver MRI, bone scintigraphy, and axial skeleton MRI. FDG PET scan appeared to be less sensitive and of low prognostic value.

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