Oncocytic Tumors: Oncocytoma, Warthin Tumor, and Acinic Cell Carcinoma

2008 ◽  
pp. 131-158 ◽  
Keyword(s):  
Cell Carcinoma ◽  
Acinic Cell Carcinoma ◽  
Warthin Tumor ◽  
Acinic Cell

Familial Occurrence of Acinic Cell Carcinoma of the Parotid Gland

1999 ◽  
Vol 123 (11) ◽  
pp. 1118-1120 ◽  
Author(s):  
Peter L. Depowski ◽  
Gavin Setzen ◽  
Alex Chui ◽  
Peter J. Koltai ◽  
James Dollar ◽  
...  
Keyword(s):  
Salivary Gland ◽  
Parotid Gland ◽  
Cell Carcinoma ◽  
Acinic Cell Carcinoma ◽  
Familial Occurrence ◽  
Salivary Gland Neoplasm ◽  
Warthin Tumor ◽  
Lymphoepithelial Lesion ◽  
Acinic Cell ◽  
Left Parotid Gland

Abstract We report the familial occurrence of acinic cell carcinoma involving the parotid gland, the first such report of which we are aware. The familial occurrence of any salivary gland neoplasm is rare. Several reports are present in the literature, including pleomorphic adenoma, Warthin tumor, carcinoma of the submandibular gland, and malignant lymphoepithelial lesion. We report the case of a 35-year-old man who underwent excision of a left parotid gland acinic cell carcinoma. Eight years later, his daughter presented at the age of 16 years with a nontender parotid gland mass that was excised and found also to be acinic cell carcinoma. The histologic features of both neoplasms were typical of acinic cell carcinoma. While this may represent a coincidental event, the possibility that this familial occurrence is a manifestation of common genetic or environmental risk cannot be excluded.

Acinic Cell Carcinoma of the Breast: Report of a Case With Immunohistochemical and Next-Generation Sequencing Studies

2021 ◽  
pp. 106689692110085
Author(s):  
Kaitlin D. Weaver ◽  
James Isom ◽  
Ashwini Esnakula ◽  
Karen Daily ◽  
Jaya R. Asirvatham
Keyword(s):  
Next Generation Sequencing ◽  
Cell Carcinoma ◽  
Triple Negative ◽  
Ductal Carcinoma ◽  
Left Breast ◽  
Acinic Cell Carcinoma ◽  
Next Generation ◽  
Carcinoma Of The Breast ◽  
Acinic Cell ◽  
Generation Sequencing

Acinic cell carcinoma of the breast is a rare subtype of triple-negative breast cancer that recapitulates the appearance of tumors seen in salivary glands. We present the case of a 42-year-old woman with an irregular, nontender mass above the left nipple during routine obstetric appointment at 24 weeks gestation. She was subsequently diagnosed with triple-negative invasive ductal carcinoma of the left breast, Nottingham grade 3, via core needle biopsy. She was treated with neoadjuvant therapy (doxorubucin and cyclophosphamide) antenatally and paclitaxel in the postpartum period followed by left mastectomy with sentinel node biopsy. The carcinoma in the mastectomy specimen showed a spectrum of morphologic patterns with immunohistochemistry revealing strong positivity for alpha-1-antichymotrypsin, epithelial membrane antigen (EMA), lysozyme, and S100. The histomorphology paired with the immunoprofile led us to the diagnosis of acinic cell carcinoma. We retrospectively performed immunostains in the core biopsy specimen, which demonstrated GATA-3 and DOG-1 positivity. Next-generation sequencing of the postneoadjuvant specimen using a 70-gene panel revealed 2 single-nucleotide variant (SNV) mutations: tumor protein 53 (TP53) (c.747G>T) SNV mutation and rearranged during transfection (RET) (c.2899G>A) SNV mutation.

scholarly journals Acinic cell carcinoma of the salivary glands: A literature review

2009 ◽  
Vol 2 (1) ◽  
pp. 259-264 ◽  
Author(s):  
Nabil Al-Zaher ◽  
Amani Obeid ◽  
Suhail Al-Salam ◽  
Bassam Sulaiman Al-Kayyali
Keyword(s):  
Literature Review ◽  
Cell Carcinoma ◽  
Salivary Glands ◽  
Acinic Cell Carcinoma ◽  
Acinic Cell

scholarly journals High-Grade Transformation of Acinic Cell Carcinoma: Potentially Underrecognized and Inadequately Treated

2016 ◽  
Vol 94 (4) ◽  
pp. 946
Author(s):  
A.V. Chintakuntlawar ◽  
W. Shon ◽  
M. Erickson-Johnson ◽  
E. Bilodeau ◽  
S. Jenkins ◽  
...  
Keyword(s):  
Cell Carcinoma ◽  
Acinic Cell Carcinoma ◽  
High Grade ◽  
Acinic Cell ◽  
High Grade Transformation

Clinicopathological analysis of oral and maxillofacial acinic cell carcinoma: A systematic review

2021 ◽  
Author(s):  
Laura Borges Kirschnick ◽  
Felipe Martins Silveira ◽  
Lauren Frenzel Schuch ◽  
Felipe Paiva Fonseca ◽  
Marco Antonio Trevizani Martins ◽  
...  
Keyword(s):  
Systematic Review ◽  
Cell Carcinoma ◽  
Acinic Cell Carcinoma ◽  
Acinic Cell ◽  
Clinicopathological Analysis

P36.01 Primary Acinic Cell Carcinoma of Bronchial Ground Origin: A Case Report

2021 ◽  
Vol 16 (10) ◽  
pp. S1062-S1063
Author(s):  
K. Hirano ◽  
H. Harada ◽  
S. Shibata ◽  
E. Chou ◽  
Y. Naka ◽  
...  
Keyword(s):  
Case Report ◽  
Cell Carcinoma ◽  
Acinic Cell Carcinoma ◽  
Acinic Cell

scholarly journals A Case Report and Genetic Characterization of a Massive Acinic Cell Carcinoma of the Parotid with Delayed Distant Metastases

2013 ◽  
Vol 2013 ◽  
pp. 1-7 ◽  
Author(s):  
Anthony C. Nichols ◽  
Michelle Chan-Seng-Yue ◽  
John Yoo ◽  
Sumit K. Agrawal ◽  
Maud H. W. Starmans ◽  
...  
Keyword(s):  
Salivary Gland ◽  
Cell Carcinoma ◽  
Large Scale ◽  
Cellular Proliferation ◽  
Genetic Characterization ◽  
Distant Metastases ◽  
Acinic Cell Carcinoma ◽  
Nonsynonymous Mutation ◽  
Acinic Cell

We describe the presentation, management, and clinical outcome of a massive acinic cell carcinoma of the parotid gland. The primary tumor and blood underwent exome sequencing which revealed deletions in CDKN2A as well as PPP1R13B, which induces p53. A damaging nonsynonymous mutation was noted in EP300, a histone acetylase which plays a role in cellular proliferation. This study provides the first insights into the genetic underpinnings of this cancer. Future large-scale efforts will be necessary to define the mutational landscape of salivary gland malignancies to identify therapeutic targets and biomarkers of treatment failure.

Acinic cell carcinoma of the parotid gland

Cancer ◽  
1966 ◽  
Vol 19 (12) ◽  
pp. 1761-1772 ◽  
Author(s):  
Carl-Magnus Eneroth ◽  
Per Å. Jakobsson ◽  
Carl Blanck
Keyword(s):  
Parotid Gland ◽  
Cell Carcinoma ◽  
Acinic Cell Carcinoma ◽  
Acinic Cell
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