Familial Occurrence of Acinic Cell Carcinoma of the Parotid Gland

1999 ◽  
Vol 123 (11) ◽  
pp. 1118-1120 ◽  
Author(s):  
Peter L. Depowski ◽  
Gavin Setzen ◽  
Alex Chui ◽  
Peter J. Koltai ◽  
James Dollar ◽  
...  
Keyword(s):  
Salivary Gland ◽  
Parotid Gland ◽  
Cell Carcinoma ◽  
Acinic Cell Carcinoma ◽  
Familial Occurrence ◽  
Salivary Gland Neoplasm ◽  
Warthin Tumor ◽  
Lymphoepithelial Lesion ◽  
Acinic Cell ◽  
Left Parotid Gland

Abstract We report the familial occurrence of acinic cell carcinoma involving the parotid gland, the first such report of which we are aware. The familial occurrence of any salivary gland neoplasm is rare. Several reports are present in the literature, including pleomorphic adenoma, Warthin tumor, carcinoma of the submandibular gland, and malignant lymphoepithelial lesion. We report the case of a 35-year-old man who underwent excision of a left parotid gland acinic cell carcinoma. Eight years later, his daughter presented at the age of 16 years with a nontender parotid gland mass that was excised and found also to be acinic cell carcinoma. The histologic features of both neoplasms were typical of acinic cell carcinoma. While this may represent a coincidental event, the possibility that this familial occurrence is a manifestation of common genetic or environmental risk cannot be excluded.

scholarly journals Dedifferentiated Acinic Cell Carcinoma of the Parotid Gland With Myoepithelial Features

2002 ◽  
Vol 126 (9) ◽  
pp. 1104-1105 ◽  
Author(s):  
Simonetta Piana ◽  
Alberto Cavazza ◽  
Corrado Pedroni ◽  
Rosa Scotti ◽  
Luigi Serra ◽  
...  
Keyword(s):  
Salivary Gland ◽  
Parotid Gland ◽  
Cell Carcinoma ◽  
Clinical Course ◽  
Acinic Cell Carcinoma ◽  
Low Grade ◽  
High Grade ◽  
Epithelial Proliferation ◽  
Acinic Cell

Abstract Dedifferentiated acinic cell carcinoma of the salivary gland is an uncommon variant of acinic cell carcinoma, characterized by the coexistence of both an usual low-grade acinic cell carcinoma and a high-grade dedifferentiated component, as well as by an accelerated clinical course. We describe a case of acinic cell carcinoma of the parotid gland in a 67-year-old woman, which recurred 4 times after surgery and radiotherapy. The recurrences consisted of residual foci of acinic cell carcinoma intermingled with a high-grade epithelial proliferation; the latter was focally constituted by cells with morphologic and immunohistochemical features of myoepithelium.

Parotid acinic cell carcinoma with undifferentiated spindle cell transformation

1994 ◽  
Vol 108 (10) ◽  
pp. 902-904
Author(s):  
Jorge A. Ferreiro ◽  
Amarjit S. Kochar
Keyword(s):  
Salivary Gland ◽  
Parotid Gland ◽  
Cell Carcinoma ◽  
Spindle Cell ◽  
Cell Transformation ◽  
Acinic Cell Carcinoma ◽  
Similar Lesion ◽  
Acinic Cell ◽  
Black Man

AbstractThis report describes a 59-year-old black man who had an acinic cell carcinoma with associated malignant spindle cell transformation in the parotid gland. To the best of our knowledge, a similar lesion in the salivary gland has not been previously reported.

scholarly journals Oxidative Stress Markers Patients with Parotid Gland Tumors: A Pilot Study

2018 ◽  
Vol 2018 ◽  
pp. 1-7 ◽  
Author(s):  
Pawel Sowa ◽  
Maciej Misiolek ◽  
Bartlomiej Pasinski ◽  
Grzegorz Bartosz ◽  
Miroslaw Soszynski ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Salivary Gland ◽  
Parotid Gland ◽  
Blood Serum ◽  
Cell Carcinoma ◽  
Salivary Gland Tumors ◽  
Acinic Cell Carcinoma ◽  
Whole Body ◽  
Acinic Cell ◽  
Parotid Gland Tumors

Salivary gland tumors account for 3–6% of tumors of the head and neck. About 80% of salivary gland tumors occur in parotid glands. Oxidative stress (OS) is implicated in the origin, development, and whole-body effects of various tumors. There are no data on the occurrence of OS in the parotid gland tumors. The aim of this study was to ascertain if whole-body OS accompanies parotid gland tumors, based first of all on oxidative modifications of blood serum proteins and other markers of OS in the serum of the patients. The group studied included 17 patients with pleomorphic adenoma, 9 patients with Warthin’s tumor, 8 patients with acinic cell carcinoma, and 24 age-matched controls. We found increased concentration of interleukin 4 in patients with acinic cell carcinoma, decreased plasma thiols, increased AOPP concentration, and decreased FRAP of blood serum in all groups of the patients while protein oxidative modifications assessed fluorimetrically, protein carbonyls, protein nitration, malondialdehyde concentration, and serum ABTS⁎-scavenging capacity were unchanged. These data indicate the occurrence of OS in patients with parotid gland tumors and point to various sensitivities of OS markers.

Multiple acinic cell carcinoma

1985 ◽  
Vol 99 (11) ◽  
pp. 1183-1193 ◽  
Author(s):  
H. Gustafsson ◽  
B. Carlsöö
Keyword(s):  
Parotid Gland ◽  
Cell Carcinoma ◽  
Submaxillary Gland ◽  
Acinic Cell Carcinoma ◽  
Salivary Gland Tumours ◽  
Acinic Cell ◽  
Ultrastructural Characteristics ◽  
The Right ◽  
Parotid Gland Tumours ◽  
Left Parotid Gland

AbstractA case is presented of multiple acinic cell carcinoma, occurring synchronously in the left parotid gland and in the right submaxillary gland of a 75-year-old male patient. Fourteen cases of primary multiple acinic cell carcinoma have previously been reported, all bilateral parotid gland tumours. To our knowledge this is the first report of extraparotid localization of an acinic cell carcinoma in a patient presenting multiple salivary gland tumours. The histologic and ultrastructural characteristics of the tumours are described and a review of the literature is given.

scholarly journals ACINIC CELL CARCINOMA OF PAROTID GLAND – A CASE REPORT

2020 ◽  
pp. 66-67
Author(s):  
J. Priyadharisini ◽  
Partho Protim Barman ◽  
U. Bharathi
Keyword(s):  
Differential Diagnosis ◽  
Salivary Gland ◽  
Parotid Gland ◽  
Cell Carcinoma ◽  
Histopathological Examination ◽  
Acinic Cell Carcinoma ◽  
Low Grade ◽  
Diagnostic Dilemma ◽  
Gold Standard Method ◽  
Acinic Cell

Acinic cell carcinoma (ACC) is a rare type of tumor which accounts for only 1–3% of the salivary gland tumors. Majority of which occurs in the parotid gland. ACC can be misinterpreted as benign because of its low grade histology. Radiological imaging techniques have low sensitivity in detecting malignancy of parotid glands. Guided FNAC can prove to be reliable diagnostic modality that can help in differential diagnosis of salivary gland neoplasms. Aspirates from these tumors can be diagnostically challenging. The lesions that have to be considered in the differential diagnosis include a wide variety of nonneoplastic as well as neoplastic conditions and pose a serious diagnostic dilemma cytologically. Hence histopathological examination is the gold standard method of choice for diagnosing these tumors. Here we report a case of Acinic cell carcinoma of parotid gland which had cytological diagnostic dilemma and confirmed diagnosis following histopathology examination.

scholarly journals A Case Report and Genetic Characterization of a Massive Acinic Cell Carcinoma of the Parotid with Delayed Distant Metastases

2013 ◽  
Vol 2013 ◽  
pp. 1-7 ◽  
Author(s):  
Anthony C. Nichols ◽  
Michelle Chan-Seng-Yue ◽  
John Yoo ◽  
Sumit K. Agrawal ◽  
Maud H. W. Starmans ◽  
...  
Keyword(s):  
Salivary Gland ◽  
Cell Carcinoma ◽  
Large Scale ◽  
Cellular Proliferation ◽  
Genetic Characterization ◽  
Distant Metastases ◽  
Acinic Cell Carcinoma ◽  
Nonsynonymous Mutation ◽  
Acinic Cell

We describe the presentation, management, and clinical outcome of a massive acinic cell carcinoma of the parotid gland. The primary tumor and blood underwent exome sequencing which revealed deletions in CDKN2A as well as PPP1R13B, which induces p53. A damaging nonsynonymous mutation was noted in EP300, a histone acetylase which plays a role in cellular proliferation. This study provides the first insights into the genetic underpinnings of this cancer. Future large-scale efforts will be necessary to define the mutational landscape of salivary gland malignancies to identify therapeutic targets and biomarkers of treatment failure.

Acinic cell carcinoma of the parotid gland

Cancer ◽  
1966 ◽  
Vol 19 (12) ◽  
pp. 1761-1772 ◽  
Author(s):  
Carl-Magnus Eneroth ◽  
Per Å. Jakobsson ◽  
Carl Blanck
Keyword(s):  
Parotid Gland ◽  
Cell Carcinoma ◽  
Acinic Cell Carcinoma ◽  
Acinic Cell

Occult Primary Parotid Gland Acinic Cell Adenocarcinoma Presenting With Extensive Lung Metastasis

2007 ◽  
Vol 131 (6) ◽  
pp. 970-973
Author(s):  
Fabio Tavora ◽  
Negar Rassaei ◽  
Konstantin Shilo ◽  
Robert D. Foss ◽  
Jeffrey R. Galvin ◽  
...  
Keyword(s):  
Salivary Gland ◽  
Parotid Gland ◽  
Clinical Evaluation ◽  
Distant Metastases ◽  
Salivary Gland Neoplasm ◽  
Regional Lymph Nodes ◽  
Acinic Cell ◽  
Parotid Carcinoma ◽  
Peripheral Lung ◽  
Gland Type

Abstract Acinic cell adenocarcinoma is a malignant salivary gland neoplasm with a relatively low rate of lymphangitic spread to regional lymph nodes. Distant metastases are rare and their occurrence typically indicates an unfavorable outcome. We encountered an unusual example of acinic cell adenocarcinoma that initially presented in the lung, whereas the primary parotid carcinoma, despite extensive clinical evaluation, only became apparent 1 year after initial diagnosis. The histologic, immunohistochemical, and ultrastructural features of the tumor in the parotid gland and lung were similar. The tumor displayed an aggressive behavior resulting in death within 2 years of the initial presentation. This presentation is unique, showing that peripheral lung tumors of salivary gland type are likely to be metastatic, and careful clinical evaluation is warranted in establishing their primary site of origin.

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