Treated with Hymen Sparing Surgery in Familial Imperforate Hymen

Imperforate hymen is a rare congenital female genital tract obstructive pathology. Although It is generally sporadic and isolated, very rare familial occurrence cases have been published in the literature. We present a rare case of the familial occurrence of IH and its surgical treatment. This case was admitted to our clinic with chronic pelvic pain, difficulty urination and pelvic mass. After the gynecologic examination and ultrasound view, the diagnosis of IH was made. Her sister who two years older than she had been previously evaluated for amenorrhea and her sister had undergone surgical procedures for IH. Because of Hymen is an important symbol of virginity in family culture, hymen sparing surgery was performed. The familial occurrence of IH is a rare condition and very few reported cases in the literature. Hymenectomy can cause social retraction in cases therefore hymen sparing surgery is an important surgery, especially Muslim cultures.

Erectile Dysfunction in Men Burdened with the Familial Occurrence of Coronary Artery Disease

Erectile dysfunction (ED) and coronary artery disease (CAD) share common risk factors, some of which have genetic backgrounds, while others may be stimulated by family lifestyle. We investigated the impact of the familial occurrence of CAD on the presence of ED and the presence of classic risk factors for ED in men with CAD. This cross-sectional observational study involved 751 men with CAD who were subjected to cardiac rehabilitation. Overall, 75.63% of the men had ED. CAD was diagnosed in 39.28% of the studied men’s relatives. ED was less frequent in the men with familial CAD than in those without (71.53% vs. 78.29%). Similar relations were observed for the presence of CAD in parents (70.43% vs. 78.34%) and the father (69.95% vs. 77.46%). The International Index of Erectile Function 5 score was significantly higher in patients with familial CAD (median (interquartile range); 17 (12–22) vs. 16 (10–21); p = 0.0118), in parents (18 (12–22) vs. 16 (10–20); p = 0.021), and in the father (18 (12–22) vs. 16 (10–21); p = 0.0499). Age and education minimized the effect of familial CAD. Familial CAD increased the incidence of hypertension, dyslipidemia, and smoking but not sedentary lifestyle. Despite the higher prevalence of selected risk factors for ED in men with familial CAD, a higher incidence of ED was not observed.

Ossifying fibroma in an adolescent boy and his mother: a case report

Cemento-ossifying fibroma is a rare benign neoplasm occurring in the tooth bearing areas of mandible and maxilla. Here we report a case of an adolescent boy who presented with swelling in the right side of mandible. It was excised surgically and histopathological diagnosis of cement-ossifying fibroma was made. His mother also had history of cemento-ossifying fibroma 10 years back. This case is being reported for its rare incidence and familial occurrence.

Two Cases of Possible Familial Chronic Myeloid Leukemia in a Family with Extensive History of Cancer

CML is defined by the presence of an oncogenic fusion protein caused by a reciprocal translocation between chromosomes 9q and 22q. While our molecular understanding of CML pathogenesis has revolutionized drug development for this disease, we have yet to identify many predisposing factors for CML. Familial occurrence of CML has been rarely reported. Here, we describe 2 cases of CML in a 24-year-old woman and in her 73-year-old maternal great aunt. We describe genetic variants in these patients and report on their environmental exposures that may have contributed to CML pathogenesis. The possible familial association of these 2 cases of CML warrants further investigation into more definitive etiologies of this disease.