Does Complexity Matter? Artificial Evolution, Computational Evolution and the Genetic Analysis of Epistasis in Common Human Diseases.

2008 ◽  
pp. 1-19 ◽  
Author(s):  
Jason H. Moore ◽  
Casey S. Greene ◽  
Peter C. Andrews ◽  
Bill C. White
Keyword(s):  
Genetic Analysis ◽  
Human Diseases ◽  
Artificial Evolution

scholarly journals Genetic analysis of quantitative traits in the Japanese population links cell types to complex human diseases

2018 ◽  
Vol 50 (3) ◽  
pp. 390-400 ◽  
Author(s):  
Masahiro Kanai ◽  
Masato Akiyama ◽  
Atsushi Takahashi ◽  
Nana Matoba ◽  
Yukihide Momozawa ◽  
...  
Keyword(s):  
Genetic Analysis ◽  
Japanese Population ◽  
Quantitative Traits ◽  
Cell Types ◽  
Human Diseases

scholarly journals Exploiting the proteome to improve the genome-wide genetic analysis of epistasis in common human diseases

2008 ◽  
Vol 124 (1) ◽  
pp. 19-29 ◽  
Author(s):  
Kristine A. Pattin ◽  
Jason H. Moore
Keyword(s):  
Genetic Analysis ◽  
Human Diseases ◽  
Genome Wide

scholarly journals Increased Instability of Human CTG Repeat Tracts on Yeast Artificial Chromosomes during Gametogenesis

1999 ◽  
Vol 19 (6) ◽  
pp. 4153-4158 ◽  
Author(s):  
Haim Cohen ◽  
Dorothy D. Sears ◽  
Drora Zenvirth ◽  
Philip Hieter ◽  
Giora Simchen
Keyword(s):  
Genetic Analysis ◽  
Trinucleotide Repeat ◽  
Mitotic Division ◽  
Human Diseases ◽  
Ctg Repeats ◽  
Artificial Chromosomes ◽  
Repeat Tract ◽  
Yeast Artificial Chromosomes ◽  
Dmpk Gene ◽  
Ctg Repeat

ABSTRACT Expansion of trinucleotide repeat tracts has been shown to be associated with numerous human diseases. The mechanism and timing of the expansion events are poorly understood, however. We show that CTG repeats, associated with the human DMPK gene and implanted in two homologous yeast artificial chromosomes (YACs), are very unstable. The instability is 6 to 10 times more pronounced in meiosis than during mitotic division. The influence of meiosis on instability is 4.4 times greater when the second YAC with a repeat tract is not present. Most of the changes we observed in trinucleotide repeat tracts are large contractions of 21 to 50 repeats. The orientation of the insert with the repeats has no effect on the frequency and distribution of the contractions. In our experiments, expansions were found almost exclusively during gametogenesis. Genetic analysis of segregating markers among meiotic progeny excluded unequal crossover as the mechanism for instability. These unique patterns have novel implications for possible mechanisms of repeat instability.

scholarly journals Emerging Trends in Deciphering the Pathogenesis of Human Diseases through Genetic Analysis

Genes ◽  
2021 ◽  
Vol 12 (1) ◽  
pp. 96
Author(s):  
David Q.-H. Wang
Keyword(s):  
Gene Expression ◽  
Genetic Analysis ◽  
Human Diseases ◽  
Human Beings ◽  
Emerging Trends ◽  
Protein Functions

Any changes in gene expression or protein functions can cause abnormal anatomical, physiological, biochemical, and behavioral modifications in human beings, which can lead to disease [...]

Experimental Amyloidosis Induced by Immune Complex

1971 ◽  
Vol 29 ◽  
pp. 582-583
Author(s):  
A. Kawaoi
Keyword(s):  
Immune Complex ◽  
Systemic Amyloidosis ◽  
Human Diseases ◽  
Experimental Amyloidosis ◽  
Freund’S Complete Adjuvant ◽  
Freund's Complete Adjuvant ◽  
Immunological Approach ◽  
Experimentally Induced

Numbers of immunological approach have been made to the amyloidosis through the variety of predisposing human diseases and the experimentally induced animals by the greater number of agents. The results suggest an important role of impaired immunity involving both humoral and cell-mediated aspects.Recently the author has succeeded in producing amyloidosis in the rabbits and mice by the injections of immune complex of heat denatured DNA.The aim of this report is to demonstrate the details of the ultrastructure of the amyloidosis induced by heterologous insoluble immune complex. Eleven of twelve mice, dd strain, subcutaneously injected twice a week with Freund's complete adjuvant and four of seven animals intraperitonially injected developed systemic amyloidosis two months later from the initial injections. The spleens were electron microscopically observed.

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