The NDUFS4 Knockout Mouse: A Dual Threat Model of Childhood Mitochondrial Disease and Normative Aging

2021 ◽  
pp. 143-155
Author(s):  
Anthony S. Grillo ◽  
Alessandro Bitto ◽  
Matt Kaeberlein
Keyword(s):  
Mitochondrial Disease ◽  
Knockout Mouse ◽  
Threat Model ◽  
Normative Aging

scholarly journals IS AGING AN ACQUIRED MITOCHONDRIAL DISEASE?

2019 ◽  
Vol 3 (Supplement_1) ◽  
pp. S394-S395
Author(s):  
Alessandro Bitto
Keyword(s):  
Mitochondrial Dysfunction ◽  
Mitochondrial Disease ◽  
Leigh Syndrome ◽  
Childhood Disorders ◽  
Normative Aging ◽  
Similarities And Differences

Abstract Mitochondrial dysfunction is a hallmark of aging, but severe mitochondrial dysfunction leads to rare childhood disorders such as Leigh Syndrome. This session explores the similarities and differences between normative aging and mitochondrial disease and the potential for interventions to positively impact both conditions.

Gene array and knockout mouse analysis of VP-16 induced apoptosis in the murine small intestine

2001 ◽  
Vol 120 (5) ◽  
pp. A660-A660
Author(s):  
D MCMICHAEL ◽  
A DAVIES ◽  
E MARSHMAN ◽  
P OTTEWELL ◽  
J JENKINS ◽  
...  
Keyword(s):  
Small Intestine ◽  
Knockout Mouse ◽  
Gene Array ◽  
Murine Small Intestine ◽  
Induced Apoptosis

Risk and Resilience From Early Experiences to Longevity: Findings From the VA Normative Aging Study

2018 ◽  
Author(s):  
Lewina O. Lee ◽  
Carolyn M. Aldwin ◽  
Laura D. Kubzansky ◽  
Daniel K. Mroczek ◽  
Avron Spiro Iii
Keyword(s):  
Risk And Resilience ◽  
Early Experiences ◽  
Normative Aging Study ◽  
Aging Study ◽  
Normative Aging

Contribution to bone mass and strength of osteoblast GH actions that are independent of local IGF-1 production: lessons from the SOCS2 knockout mouse

2013 ◽  
pp. 1-1
Author(s):  
Ross Dobie ◽  
Vicky MacRae ◽  
Carmen Huesa ◽  
Hof Rob van't ◽  
Faisal Ahmed ◽  
...  
Keyword(s):  
Bone Mass ◽  
Knockout Mouse
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