Learning Paradigms and Genetic Tools for the Study of Cerebellum-Dependent Learning and Memory

2022 ◽  
pp. 109-132
Author(s):  
Akira Katoh
Keyword(s):  
Learning And Memory ◽  
Genetic Tools ◽  
Dependent Learning

scholarly journals Clock/Sleep-Dependent Learning and Memory in Male 3xTg-AD Mice at Advanced Disease Stages and Extrinsic Effects of Huprine X and the Novel Multitarget Agent AVCRI104P3

2021 ◽  
Vol 11 (4) ◽  
pp. 426
Author(s):  
Lydia Giménez-Llort ◽  
Mikel Santana-Santana ◽  
Míriam Ratia ◽  
Belén Pérez ◽  
Pelayo Camps ◽  
...  
Keyword(s):  
Learning And Memory ◽  
Advanced Disease ◽  
Active Phase ◽  
Task Demands ◽  
The Novel ◽  
Training Time ◽  
Drug Effectiveness ◽  
Dependent Learning ◽  
Disease Stages

A new hypothesis highlights sleep-dependent learning/memory consolidation and regards the sleep-wake cycle as a modulator of β-amyloid and tau Alzheimer’s disease (AD) pathologies. Sundowning behavior is a common neuropsychiatric symptom (NPS) associated with dementia. Sleep fragmentation resulting from disturbances in sleep and circadian rhythms in AD may have important consequences on memory processes and exacerbate the other AD-NPS. The present work studied the effect of training time schedules on 12-month-old male 3xTg-AD mice modeling advanced disease stages. Their performance in two paradigms of the Morris water maze for spatial-reference and visual-perceptual learning and memory were found impaired at midday, after 4 h of non-active phase. In contrast, early-morning trained littermates, slowing down from their active phase, exhibited better performance and used goal-directed strategies and non-search navigation described for normal aging. The novel multitarget anticholinesterasic compound AVCRI104P3 (0.6 µmol·kg−1, 21 days i.p.) exerted stronger cognitive benefits than its in vitro equipotent dose of AChEI huprine X (0.12 μmol·kg−1, 21 days i.p.). Both compounds showed streamlined drug effectiveness, independently of the schedule. Their effects on anxiety-like behaviors were moderate. The results open a question of how time schedules modulate the capacity to respond to task demands and to assess/elucidate new drug effectiveness.

scholarly journals Kv4.2 knockout mice have hippocampal-dependent learning and memory deficits

2012 ◽  
Vol 19 (5) ◽  
pp. 182-189 ◽  
Author(s):  
J. N. Lugo ◽  
A. L. Brewster ◽  
C. M. Spencer ◽  
A. E. Anderson
Keyword(s):  
Learning And Memory ◽  
Knockout Mice ◽  
Memory Deficits ◽  
Learning And Memory Deficits ◽  
Dependent Learning

scholarly journals The brain-tumor related protein podoplanin regulates synaptic plasticity and hippocampus-dependent learning and memory

2016 ◽  
Vol 48 (8) ◽  
pp. 652-668 ◽  
Author(s):  
Ana Cicvaric ◽  
Jiaye Yang ◽  
Sigurd Krieger ◽  
Deeba Khan ◽  
Eun-Jung Kim ◽  
...  
Keyword(s):  
Brain Tumor ◽  
Synaptic Plasticity ◽  
Learning And Memory ◽  
Related Protein ◽  
Dependent Learning ◽  
The Brain

scholarly journals Long-Term Pharmacological Inhibition of the Activity of All NOS Isoforms Rather Than Genetic Knock-Out of Endothelial NOS Leads to Impaired Spatial Learning and Memory in C57BL/6 Mice

Biomedicines ◽  
2021 ◽  
Vol 9 (12) ◽  
pp. 1905
Author(s):  
Jhana O. Hendrickx ◽  
Sofie De Moudt ◽  
Elke Calus ◽  
Peter Paul De Deyn ◽  
Debby Van Dam ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Arterial Stiffness ◽  
Cognitive Decline ◽  
Learning And Memory ◽  
Selective Inhibition ◽  
Underlying Mechanism ◽  
Spatial Learning And Memory ◽  
Potential Contribution ◽  
Knock Out ◽  
Dependent Learning

Increasing epidemiological and experimental evidence points to a link between arterial stiffness and rapid cognitive decline. However, the underlying mechanism linking the two diseases is still unknown. The importance of nitric oxide synthases in both diseases is well-defined. In this study, we introduced arterial stiffness in both genetic (eNOS−/−, endothelial nitric oxide synthase knockout) and pharmacological (N(G)-nitro-L-arginine methyl ester (L-NAME) treatment) NO dysfunction models to study their association with cognitive decline. Our findings demonstrate that the non-selective inhibition of NOS activity with L-NAME induces cardiac dysfunction, arterial stiffness, and a decline in hippocampal-dependent learning and memory. This outcome demonstrates the importance of neuronal NOS (nNOS) in both cardiovascular and neurological pathophysiology and its potential contribution in the convergence between arterial stiffness and cognitive decline.

Differential effects of quercetin on hippocampus-dependent learning and memory in mice fed with different diets related with oxidative stress

2015 ◽  
Vol 138 ◽  
pp. 325-331 ◽  
Author(s):  
Shu-Fang Xia ◽  
Zhen-Xing Xie ◽  
Yi Qiao ◽  
Li-Rong Li ◽  
Xiang-Rong Cheng ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Learning And Memory ◽  
Differential Effects ◽  
Dependent Learning
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