Active metabolites of tricyclic antidepressants

1981 ◽  
pp. 139-153 ◽  
Author(s):  
William Z. Potter
Keyword(s):  
Tricyclic Antidepressants ◽  
Active Metabolites

scholarly journals Stir bar sorptive-dispersive microextraction by a poly(methacrylic acid-co-ethylene glycol dimethacrylate)-based magnetic sorbent for the determination of tricyclic antidepressants and their main active metabolites in human urine

2022 ◽  
Vol 189 (2) ◽  
Author(s):  
Víctor Vállez-Gomis ◽  
Sara Exojo-Trujillo ◽  
Juan L. Benedé ◽  
Alberto Chisvert ◽  
Amparo Salvador
Keyword(s):  
Ethylene Glycol ◽  
Methacrylic Acid ◽  
Human Urine ◽  
Tricyclic Antidepressants ◽  
Urine Samples ◽  
Glycol Dimethacrylate ◽  
Active Metabolites ◽  
Magnetic Sorbent ◽  
Dispersive Microextraction

Abstract A poly(methacrylic acid-co-ethylene glycol dimethacrylate)-based magnetic sorbent was used for the rapid and sensitive determination of tricyclic antidepressants and their main active metabolites in human urine. This material was characterized by magnetism measurements, zeta potential, scanning electron microscopy, nitrogen adsorption–desorption isotherms, and thermogravimetric analysis. The proposed analytical method is based on stir bar sorptive-dispersive microextraction (SBSDME) followed by liquid chromatography–tandem mass spectrometry. The main parameters involved in the extraction step were optimized by using the response surface methodology as a multivariate optimization method, whereas a univariate approach was employed to study the desorption parameters. Under the optimized conditions, the proposed method was properly validated showing good linearity (at least up to 50 ng mL−1) and enrichment factors (13–22), limits of detection and quantification in the low ng L−1 range (1.4–7.0 ng L−1), and good intra- and inter-day repeatability (relative standard deviations below 15%). Matrix effects were observed for the direct analysis of urine samples, but they were negligible when a 1:1 v/v dilution with deionized water was performed. Finally, the method was successfully applied to human urine samples from three volunteers, one of them consuming a prescribed drug for depression that tested positive for clomipramine and its main active metabolite. Quantitative relative recoveries (80–113%) were obtained by external calibration. The present work expands the applicability of the SBSDME to new analytes and new types of magnetic sorbents. Graphical abstract

Tricyclic Antidepressants: Contemporary Issues for Therapeutic Practice

1989 ◽  
Vol 34 (6) ◽  
pp. 609-617 ◽  
Author(s):  
Bruce G. Pollock ◽  
James M. Perel
Keyword(s):  
Clinical Pharmacology ◽  
Plasma Concentration ◽  
Therapeutic Drug Monitoring ◽  
Drug Monitoring ◽  
Tricyclic Antidepressants ◽  
Medical Condition ◽  
Therapeutic Drug ◽  
Active Metabolites ◽  
Therapeutic Practice ◽  
Check Compliance

The clinical pharmacology of tricyclic antidepressants is reviewed, with an emphasis on recent findings. These medications have become the treatment of choice for the majority of depressed patients. Their efficacy is limited by lack of vigor and precision in dosage. Pharmacokinetic aspects are addressed which affect the rationale for selective use and interpretation of plasma concentration monitoring. These include nonlinearity, active metabolites, plasma protein binding and age effects. Specific indications for therapeutic drug monitoring occur with patients who fail to respond, those at risk because of age, medical condition or polypharmacy, and to check compliance. Integration of knowledge concerning pharmacokinetics and plasma levels with clinical response will aid in making appropriate pharmacotherapeutic decisions.

Anti-allodynic effecis of tricyclic antidepressants in TNBS-induced chronic colonic hypersensitivity

2001 ◽  
Vol 120 (5) ◽  
pp. A329-A329
Author(s):  
S CASET ◽  
C BERTRAND ◽  
A DOHERTY
Keyword(s):  
Tricyclic Antidepressants

Review of Living With Tricyclic Antidepressants.

1997 ◽  
Vol 42 (1) ◽  
pp. 84-84
Author(s):  
Terri Gullickson
Keyword(s):  
Tricyclic Antidepressants

EFFECT OF HORMONE-ACTIVE METABOLITES OF CHOLECALCIFEROL ON THE STATE OF THE ORAL CAVITY TISSUES IN RATS UNDER THE CONDITIONS OF ESTROGEN DEFICIENCY AND TRAUMATIC STRESS

2020 ◽  
Vol 16 (73) ◽  
pp. 247
Author(s):  
S.A. Schnaider ◽  
V.V. Humeniuk ◽  
V.N. Horokhivskyi ◽  
O.V. Yefremova ◽  
M.T. Khristova ◽  
...  
Keyword(s):  
Oral Cavity ◽  
Traumatic Stress ◽  
Estrogen Deficiency ◽  
The State ◽  
Active Metabolites
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