Alpha2a-Adrenoceptors in Microsomes from Human Saphenous Vein

1995 ◽  
pp. 189-192
Author(s):  
R. Hanf ◽  
G. Le Filliatre ◽  
F. Mardon ◽  
P. Luce ◽  
M. Finet
Keyword(s):  
Saphenous Vein ◽  
Human Saphenous Vein

scholarly journals High stretch induces endothelial dysfunction accompanied by oxidative stress and actin remodeling in human saphenous vein endothelial cells

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
T. Girão-Silva ◽  
M. H. Fonseca-Alaniz ◽  
J. C. Ribeiro-Silva ◽  
J. Lee ◽  
N. P. Patil ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Endothelial Cells ◽  
Endothelial Cell ◽  
Endothelial Dysfunction ◽  
Saphenous Vein ◽  
Saphenous Vein Graft ◽  
Artery Bypass ◽  
Bypass Graft ◽  
Human Saphenous Vein ◽  
Actin Remodeling

AbstractThe rate of the remodeling of the arterialized saphenous vein conduit limits the outcomes of coronary artery bypass graft surgery (CABG), which may be influenced by endothelial dysfunction. We tested the hypothesis that high stretch (HS) induces human saphenous vein endothelial cell (hSVEC) dysfunction and examined candidate underlying mechanisms. Our results showed that in vitro HS reduces NO bioavailability, increases inflammatory adhesion molecule expression (E-selectin and VCAM1) and THP-1 cell adhesion. HS decreases F-actin in hSVECs, but not in human arterial endothelial cells, and is accompanied by G-actin and cofilin’s nuclear shuttling and increased reactive oxidative species (ROS). Pre-treatment with the broad-acting antioxidant N-acetylcysteine (NAC) supported this observation and diminished stretch-induced actin remodeling and inflammatory adhesive molecule expression. Altogether, we provide evidence that increased oxidative stress and actin cytoskeleton remodeling play a role in HS-induced saphenous vein endothelial cell dysfunction, which may contribute to predisposing saphenous vein graft to failure.

Phenotype Gradation of Human Saphenous Vein Endothelial Cells from Cardiovascular Disease Subjects

Endothelium ◽  
2006 ◽  
Vol 13 (5) ◽  
pp. 341-352 ◽  
Author(s):  
C. Krishna Prasad ◽  
K. Jayakumar ◽  
Lissy K. Krishnan
Keyword(s):  
Cardiovascular Disease ◽  
Endothelial Cells ◽  
Saphenous Vein ◽  
Human Saphenous Vein

scholarly journals Cross-talk between angiotensin II and IGF-1-induced connexin 43 expression in human saphenous vein smooth muscle cells

2011 ◽  
Vol 15 (8) ◽  
pp. 1695-1702 ◽  
Author(s):  
Guanghong Jia ◽  
Anshu Aggarwal ◽  
Amanuel Yohannes ◽  
Deepak M. Gangahar ◽  
Devendra K. Agrawal
Keyword(s):  
Smooth Muscle ◽  
Angiotensin Ii ◽  
Smooth Muscle Cells ◽  
Cross Talk ◽  
Saphenous Vein ◽  
Connexin 43 ◽  
Muscle Cells ◽  
Human Saphenous Vein

Nature and origin of the neointima in whole vessel wall organ culture of the human saphenous vein

1996 ◽  
Vol 428 (1) ◽  
pp. 59-67 ◽  
Author(s):  
J. Slomp ◽  
A. C. Gittenberger-de Groot ◽  
J. C. van Munsteren ◽  
R. E. Poelmann ◽  
H. A. Huysmans ◽  
...  
Keyword(s):  
Organ Culture ◽  
Saphenous Vein ◽  
Vessel Wall ◽  
Human Saphenous Vein
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