Combined Cyclopiazonic Acid and Aflatoxin B1 Effects on Serum Bacteriostasis, Complement Activity, Glycocholic Acid, and Enzymes and Histopathologic Changes in Guinea Pigs

1990 ◽  
pp. 441-449
Author(s):  
J. L. Richard ◽  
W. M. Peden ◽  
J. R. Thurston
Keyword(s):  
Aflatoxin B1 ◽  
Guinea Pigs ◽  
Cyclopiazonic Acid ◽  
Complement Activity ◽  
Glycocholic Acid ◽  
Histopathologic Changes

PARALLEL STUDIES OF COMPLEMENT AND COAGULATION IV. EFFECT OF CARBON TETRACHLORIDE

1951 ◽  
Vol 29 (2) ◽  
pp. 48-58
Author(s):  
Christine E. Rice ◽  
Paul Boulanger ◽  
P. J. G. Plummer
Keyword(s):  
Carbon Tetrachloride ◽  
Liver Injury ◽  
Serum Protein ◽  
Guinea Pigs ◽  
Fatty Degeneration ◽  
Blood Groups ◽  
Total Serum Protein ◽  
Total Serum ◽  
Coagulation Time ◽  
Complement Activity

To determine whether liver injury would result in a parallel decline in the complement titer and coagulative properties of the blood, groups of guinea pigs were given series of injections of the liver poison, carbon tetrachloride. Marked fatty degeneration of the liver, a decline in total serum protein and albumin, a decrease in complement activity, and a prolongation of coagulation time was observed in the treated animals. A general relationship was noted between the albumin-globulin ratio and the complement titer of the serum and between the complement titer and the coagulation time of the plasma.

scholarly journals Streptomyces roseolus, A Promising Biocontrol Agent Against Aspergillus flavus, the Main Aflatoxin B1 Producer

Toxins ◽  
2018 ◽  
Vol 10 (11) ◽  
pp. 442 ◽  
Author(s):  
Isaura Caceres ◽  
Selma Snini ◽  
Olivier Puel ◽  
Florence Mathieu
Keyword(s):  
Aspergillus Flavus ◽  
Aflatoxin B1 ◽  
Biocontrol Agent ◽  
Cyclopiazonic Acid ◽  
Over Expression ◽  
Expression Of Genes ◽  
B1 Gene ◽  
Genes Encoding ◽  
Molecular Mechanism Of Action ◽  
Potential Use

Crop contamination by aflatoxin B1 is a current problem in tropical and subtropical regions. In the future, this contamination risk may be expanded to European countries due to climate change. The development of alternative strategies to prevent mycotoxin contamination that further contribute to the substitution of phytopharmaceutical products are thus needed. For this, a promising method resides in the use of biocontrol agents. Several actinobacteria strains have demonstrated to effectively reduce the aflatoxin B1 concentration. Nevertheless, the molecular mechanism of action by which these biological agents reduce the mycotoxin concentration has not been determined. The aim of the present study was to test the potential use of Streptomyces roseolus as a biocontrol agent against aflatoxin B1 contamination. Co-cultures with Aspergillus flavus were conducted, and the molecular fungal response was investigated through analyzing the q-PCR expression of 65 genes encoding relevant fungal functions. Moreover, kojic and cyclopiazonic acid concentrations, as well as morphological fungal changes were also analyzed. The results demonstrated that reduced concentrations of aflatoxin B1 and kojic acid were respectively correlated with the down-regulation of the aflatoxin B1 gene cluster and kojR gene expression. Moreover, a fungal hypersporulated phenotype and a general over-expression of genes involved in fungal development were observed in the co-culture condition.

Social confrontation in male guinea pigs: Behavior, experience, and complement activity

1996 ◽  
Vol 60 (1) ◽  
pp. 235-241 ◽  
Author(s):  
Volker Stefanski ◽  
Hubert Hendrichs
Keyword(s):  
Guinea Pigs ◽  
Complement Activity ◽  
Social Confrontation

Combined effects of the mycotoxins aflatoxin B1 and cyclopiazonic acid on Sprague-Dawley rats

1987 ◽  
Vol 25 (11) ◽  
pp. 837-842 ◽  
Author(s):  
R.E. Morrissey ◽  
W.P. Norred ◽  
D.M. Hinton ◽  
R.J. Cole ◽  
J.W. Dorner
Keyword(s):  
Aflatoxin B1 ◽  
Cyclopiazonic Acid ◽  
Combined Effects ◽  
Sprague Dawley ◽  
Sprague Dawley Rats

Effects of cyclopiazonic acid and aflatoxin singly and in combination on selected clinical, pathological and immunological responses of guinea pigs

1989 ◽  
Vol 105 (3) ◽  
pp. 135-142 ◽  
Author(s):  
A. C. Pier ◽  
E. L. Belden ◽  
J. A. Ellis ◽  
E. W. Nelson ◽  
L. R. Maki
Keyword(s):  
Guinea Pigs ◽  
Cyclopiazonic Acid ◽  
Immunological Responses

Effect of Aflatoxin on Complement Activity in Guinea Pigs

1972 ◽  
Vol 139 (1) ◽  
pp. 300-303 ◽  
Author(s):  
J. R. Thurston ◽  
J. L. Richard ◽  
S. J. Cysewski ◽  
A. C. Pier ◽  
C. K. Graham
Keyword(s):  
Guinea Pigs ◽  
Complement Activity

Effects of single oral doses of scopoletin and aflatoxin B1 on the bleeding time, serum cholesterol and phospholipid levels of guinea pigs

1996 ◽  
Vol 16 (4) ◽  
pp. 667-672 ◽  
Author(s):  
Sebastian C. Obasi ◽  
Obioma U Njoku ◽  
Onyechi Obidoa ◽  
Ikpendu C. Ononogbu
Keyword(s):  
Serum Cholesterol ◽  
Aflatoxin B1 ◽  
Guinea Pigs ◽  
Bleeding Time ◽  
Oral Doses
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