Stereotactic Bragg Peak Proton Beam Therapy

1988 ◽  
pp. 463-470 ◽  
Author(s):  
Raymond N. Kjellberg ◽  
Masamitsu Abe
Keyword(s):  
Proton Beam ◽  
Bragg Peak ◽  
Proton Beam Therapy

scholarly journals Transitions of Liver and Biliary Enzymes during Proton Beam Therapy for Hepatocellular Carcinoma

Cancers ◽  
2020 ◽  
Vol 12 (7) ◽  
pp. 1840
Author(s):  
Taisuke Sumiya ◽  
Masashi Mizumoto ◽  
Yoshiko Oshiro ◽  
Keiichiro Baba ◽  
Motohiro Murakami ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Proton Beam ◽  
Liver Damage ◽  
Bragg Peak ◽  
Total Bilirubin ◽  
Normal Liver ◽  
Proton Beam Therapy ◽  
Gamma Glutamyl Transpeptidase ◽  
Preserve Liver Function ◽  
Glutamyl Transpeptidase

Proton beam therapy (PBT) is a curative treatment for hepatocellular carcinoma (HCC), because it can preserve liver function due to dose targeting via the Bragg peak. However, the degree of direct liver damage by PBT is unclear. In this study, we retrospectively analyzed liver/biliary enzymes and total bilirubin (T-Bil) as markers of direct liver damage during and early after PBT in 300 patients. The levels of these enzymes and bilirubin were almost stable throughout the treatment period. In patients with normal pretreatment levels, aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), gamma-glutamyl transpeptidase (GGT), and T-Bil were abnormally elevated in only 2 (1.2%), 1 (0.4%), 0, 2 (1.2%), and 8 (3.5%) patients, respectively, and in 8 of these 13 patients (61.5%) the elevations were temporary. In patients with abnormal pretreatment levels, the levels tended to decrease during PBT. GGT and T-Bil were elevated by 1.62 and 1.57 times in patients who received 66 Gy (RBE) in 10 fractions and 74 Gy (RBE) in 37 fractions, respectively, but again these changes were temporary. These results suggest that direct damage to normal liver caused by PBT is minimal, even if a patient has abnormal pretreatment enzyme levels.

scholarly journals The Radiobiological Effects of Proton Beam Therapy: Impact on DNA Damage and Repair

Cancers ◽  
2019 ◽  
Vol 11 (7) ◽  
pp. 946 ◽  
Author(s):  
Eirini Terpsi Vitti ◽  
Jason L Parsons
Keyword(s):  
Dna Damage ◽  
Dna Repair ◽  
Proton Beam ◽  
Bragg Peak ◽  
Proton Beam Therapy ◽  
High Energy ◽  
High Let ◽  
Repair Pathways ◽  
Radiobiological Effects ◽  
Photon Radiotherapy

Proton beam therapy (PBT) offers significant benefit over conventional (photon) radiotherapy for the treatment of a number of different human cancers, largely due to the physical characteristics. In particular, the low entrance dose and maximum energy deposition in depth at a well-defined region, the Bragg peak, can spare irradiation of proximal healthy tissues and organs at risk when compared to conventional radiotherapy using high-energy photons. However, there are still biological uncertainties reflected in the relative biological effectiveness that varies along the track of the proton beam as a consequence of the increases in linear energy transfer (LET). Furthermore, the spectrum of DNA damage induced by protons, particularly the generation of complex DNA damage (CDD) at high-LET regions of the distal edge of the Bragg peak, and the specific DNA repair pathways dependent on their repair are not entirely understood. This knowledge is essential in understanding the biological impact of protons on tumor cells, and ultimately in devising optimal therapeutic strategies employing PBT for greater clinical impact and patient benefit. Here, we provide an up-to-date review on the radiobiological effects of PBT versus photon radiotherapy in cells, particularly in the context of DNA damage. We also review the DNA repair pathways that are essential in the cellular response to PBT, with a specific focus on the signaling and processing of CDD induced by high-LET protons.

Bragg-Peak Proton-Beam Therapy for Arteriovenous Malformations of the Brain

1983 ◽  
Vol 309 (5) ◽  
pp. 269-274 ◽  
Author(s):  
Raymond N. Kjellberg ◽  
Tetsu Hanamura ◽  
Kenneth R. Davis ◽  
Susan L. Lyons ◽  
Raymond D. Adams
Keyword(s):  
Proton Beam ◽  
Arteriovenous Malformations ◽  
Bragg Peak ◽  
Proton Beam Therapy ◽  
The Brain

Bragg Peak Proton Beam Therapy for Arteriovenous Malformation of the Brain

Neurosurgery ◽  
1984 ◽  
Vol 31 (CN_suppl_1) ◽  
pp. 248-290 ◽  
Author(s):  
Raymond N. Kjellberg ◽  
Kenneth R. Davis ◽  
Susan Lyons ◽  
William Butler ◽  
Raymond D. Adams
Keyword(s):  
Arteriovenous Malformation ◽  
Proton Beam ◽  
Bragg Peak ◽  
Proton Beam Therapy ◽  
The Brain

scholarly journals Calculation of energy loss of proton beam on thyroid tumor

2020 ◽  
pp. 80-85
Author(s):  
K. Giri ◽  
B. Paudel ◽  
B.R. Gautam
Keyword(s):  
Energy Loss ◽  
Proton Beam ◽  
Skeletal Muscles ◽  
Bragg Peak ◽  
Reference Data ◽  
Proton Beam Therapy ◽  
Thyroid Tumor ◽  
Range Data ◽  
Proton Beam Irradiation ◽  
Efficient Treatment

Proton beam therapy is an emerging technique in radiotherapy. The Bragg peak of a proton enables it to lose most of its energy to the targeted tissue like tumor cells, with less impact of healthy tissues and organs. This property of a proton beam makes it ideal for clinical applications. When organ safekeeping is our priority then proton beam therapy is the most effective tool to damage nearby affected tissues. For efficient treatment planning in thyroid tumor, the maximal energy loss of proton beam in its tissues must be exactly calculated. The method of computer simulation is employed for the calculation of energy loss by energized proton beam irradiation on thyroid tumor at a depth of 22 mm. The stopping power and range data agrees with standard reference data. Of the 50 MeV energy of proton beam, the most of the energy is absorbed on various layers viz. skin, adipose tissue, skeletal muscles and thyroid which are approximately 1.5 MeV, 5.3 MeV, 10.5 MeV and 33.5 MeV respectively. In total 99.96% of energy of proton beam is absorbed by the targeted tissues.

Complications after Proton Beam Therapy to Skull Base Tumors: Case Series

2019 ◽  
Author(s):  
Gustavo Rangel ◽  
Mostafa Shahein ◽  
Thiago Felicio ◽  
Guilhermo Malave ◽  
Nyall London ◽  
...  
Keyword(s):  
Skull Base ◽  
Proton Beam ◽  
Case Series ◽  
Proton Beam Therapy ◽  
Skull Base Tumors

Proton Beam Therapy for Unresectable Adenoid Cystic Carcinoma of the Skull Base

Skull Base ◽  
2008 ◽  
Vol 18 (S 01) ◽  
Author(s):  
Annie Chan ◽  
Paul Busse ◽  
Urmila Kamat ◽  
Derrick Lin ◽  
Norbert Liebsch
Keyword(s):  
Adenoid Cystic Carcinoma ◽  
Skull Base ◽  
Proton Beam ◽  
Proton Beam Therapy ◽  
Adenoid Cystic
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