Future Potential of Cytokines and Growth Factors in Transfusion Medicine: What New Horizons are There to Come?

Author(s):  
B. Löwenberg
1999 ◽  
Vol 123 (8) ◽  
pp. 672-676
Author(s):  
Ronald A. Sacher ◽  
S. Gerald Sandler

Abstract The final decade of the last century of the second millennium ad has seen dramatic changes in all aspects of science and health care. In transfusion medicine, the blood supply is the safest it has ever been. Newer refinements and innovations are continuously being researched and implemented to achieve and further enhance safety. Advances in blood conservation, pharmacologic manipulation, engineered blood derivatives, and recombinant growth factors can now provide safer and more effective alternatives to blood transfusions for many patients. This overview highlights selective innovations in transfusion medicine and emphasizes some significant advances that have occurred in blood donor screening, blood component collections and therapy, and laboratory testing. Newer technologies are anticipated that will further enhance the safety of blood and transfusions and potentially augment annually the blood supply on a worldwide basis.


1996 ◽  
Vol 165 (6) ◽  
pp. 303-304
Author(s):  
Kerrie Clarke ◽  
Russell Basser ◽  
Richard M Fox
Keyword(s):  

Vox Sanguinis ◽  
1996 ◽  
Vol 71 (4) ◽  
pp. 196-204 ◽  
Author(s):  
Yvette M. Miller ◽  
Harvey G. Klein

2021 ◽  
Vol 11 ◽  
Author(s):  
Ntombikayise Xelwa ◽  
Geoffrey Patrick Candy ◽  
John Devar ◽  
Jones Omoshoro-Jones ◽  
Martin Smith ◽  
...  

Pancreatic cancer is one of the most deadly cancers, ranking amongst the top leading cause of cancer related deaths in developed countries. Features such as dense stroma microenvironment, abnormal signaling pathways, and genetic heterogeneity of the tumors contribute to its chemoresistant characteristics. Amongst these features, growth factors have been observed to play crucial roles in cancer cell survival, progression, and chemoresistance. Here we review the role of the individual growth factors in pancreatic cancer chemoresistance. Importantly, the interplay between the tumor microenvironment and chemoresistance is explored in the context of pivotal role played by growth factors. We further describe current and future potential therapeutic targeting of these factors.


2021 ◽  
Vol 77 (3) ◽  
Author(s):  
Johan Buitendag ◽  
Corneliu C. Simut

This article’s premise is that science holds the promise of deepening religious perspectives on creation. The natural sciences have convincingly proved that nature is not static, or a ready-made creation dropped from heaven. Theologians need to read nature as scientists see it and engage with that understanding theologically.The concept of resonance is applied to denote this tangential relationship as an eco-social constructivist understanding of reality. Two proponents, one scientist and one theologian, have been chosen who share this view of a holistic reality, and the objective is to determine the degree of resonance viable of these magisteria. A method of polycentric hermeneutics is thus pursued.Although we referred to the concept of consilience regarding von Humboldt’s enterprise, it is not in the authors’ scope to achieve this with science and theology as disciplines sui generis. However, if resonance becomes vital in understanding reality, faith is inevitable (Anselm). If a creation theology seeks a degree of plausibility, it requires the feedback-loop methodology of science. We all share one earth: the closer we all come to a shared end, the closer we also come together and relativise differences. The naturalist Edward O. Wilson suggested that science and religion should set aside their differences to save the planet. Resonance has the potential to let new horizons emerge in our mutual endeavour to come to grips with reality and to map out certain tangentially overlapping magisteria.Contribution: Through resonance, the thought constructs of a scientist and a theologian are juxtaposed. An iterative hermeneutics’ importance is emphasised in the theology and science discourse, if faith seeks understanding and leads to awe. And the conclusion is that the ‘spiritual dimension’ and the ‘natural dimension’ do not only overlap but are tangential, as they engage with the same reality.


1991 ◽  
Vol 5 (1) ◽  
pp. 33-47 ◽  
Author(s):  
Hans-G. Klingemann ◽  
John D. Shepherd ◽  
Connie J. Eaves ◽  
Allen C. Eaves

1999 ◽  
Vol 48 (2) ◽  
pp. 465-466 ◽  
Author(s):  
Wendy Kennett

The Treaty of Amsterdam, expected to come into force this year, opened up new horizons in relation to European civil procedure. Article 65 of the revised EC Treaty will bring various aspects of civil procedure within the scope of Community law, in so far as they are “necessary for the proper functioning of the internal market”.1 It states:


2012 ◽  
Vol 15 (1) ◽  
pp. 124 ◽  
Author(s):  
Clémence Tabélé ◽  
Marc Montana ◽  
Christophe Curti ◽  
Thierry Terme ◽  
Pascal Rathelot ◽  
...  

Since 1976, fibrin glues have been attracting medical interest, spreading from their initial use as a hemostatic agent in cardiovascular surgery to other fields of surgery. Studies have compared the efficacy of fibrin glues vs sutures in surgery. However, few comparisons have been made of the efficacy and safety of the different fibrin glues commercially available. Recently, fibrin glues have been tested as a scaffold delivery system for various substances inside the body (drugs, growth factors, stem cells). The infectious risk (viruses, new germs) of this blood-derived product was also studied in assays on viral inactivation methods. The development of autologous fibrin glues offers a solution to the problem of infectious risk. This review examines the current state of knowledge on the efficacy, safety and future potential of fibrin glues. This article is open to POST-PUBLICATION REVIEW. Registered readers (see “For Readers”) may comment by clicking on ABSTRACT on the issue’s contents page.


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