Malignant Catarrhal Fever and the Gammaherpesvirinae of Bovidae

1989 ◽  
pp. 116-162 ◽  
Author(s):  
H. W. Reid ◽  
D. Buxton
Keyword(s):  
Malignant Catarrhal Fever

CD8+/perforin+/WC1− γδ T cells, not CD8+ αβ T cells, infiltrate vasculitis lesions of American bison (Bison bison) with experimental sheep-associated malignant catarrhal fever

2010 ◽  
Vol 136 (3-4) ◽  
pp. 284-291 ◽  
Author(s):  
Danielle D. Nelson ◽  
William C. Davis ◽  
Wendy C. Brown ◽  
Hong Li ◽  
Donal O’Toole ◽  
...  
Keyword(s):  
T Cells ◽  
Γδ T Cells ◽  
Bison Bison ◽  
Malignant Catarrhal Fever ◽  
Αβ T Cells

Outbreak of malignant catarrhal fever among cattle associated with a state livestock exhibition

2010 ◽  
Vol 237 (1) ◽  
pp. 87-92 ◽  
Author(s):  
Dale A. Moore ◽  
Paul Kohrs ◽  
Timothy Baszler ◽  
Cynthia Faux ◽  
Peter Sathre ◽  
...  
Keyword(s):  
Malignant Catarrhal Fever

scholarly journals Sheep associated malignant catarrhal fever: an emerging disease of bovids in India

2013 ◽  
Vol 24 (3) ◽  
pp. 321-331 ◽  
Author(s):  
Richa Sood ◽  
D. Hemadri ◽  
S. Bhatia
Keyword(s):  
Emerging Disease ◽  
Malignant Catarrhal Fever

Clinical, serological and molecular evidence of sheep-associated malignant catarrhal fever in India

2004 ◽  
Vol 155 (8) ◽  
pp. 242-244 ◽  
Author(s):  
S. A. Wani ◽  
M. A. Bhat ◽  
I. Samanta ◽  
S. M. Ishaq ◽  
F. Pandit ◽  
...  
Keyword(s):  
Molecular Evidence ◽  
Malignant Catarrhal Fever

Malignant catarrhal fever caused by ovine herpesvirus-2 in pigs in Norway

1998 ◽  
Vol 143 (17) ◽  
pp. 464-467 ◽  
Author(s):  
T. Loken ◽  
M. Aleksandersen ◽  
H. W. Reid ◽  
I. Pow
Keyword(s):  
Malignant Catarrhal Fever

scholarly journals Molecular confirmation of ovine herpesvirus 2-induced malignant catarrhal fever lesions in cattle from Rio Grande do Norte, Brazil

2012 ◽  
Vol 32 (12) ◽  
pp. 1213-1218 ◽  
Author(s):  
Selwyn A. Headley ◽  
Isadora K.F. Sousa ◽  
Antonio H.H. Minervino ◽  
Isabella O. Barros ◽  
Raimundo A. Barrêto Júnior ◽  
...  
Keyword(s):  
Lymph Node ◽  
Mesenteric Lymph Node ◽  
Protein Gene ◽  
Rio Grande ◽  
Corneal Opacity ◽  
Tegument Protein ◽  
Nasal Discharge ◽  
Malignant Catarrhal Fever ◽  
Base Pairs ◽  
Mesenteric Lymph

Molecular findings that confirmed the participation of ovine herpesvirus 2 (OVH-2) in the lesions that were consistent with those observed in malignant catarrhal fever of cattle are described. Three mixed-breed cattle from Rio Grande do Norte state demonstrated clinical manifestations that included mucopurulent nasal discharge, corneal opacity and motor incoordination. Routine necropsy examination demonstrated ulcerations and hemorrhage of the oral cavity, corneal opacity, and lymph node enlargement. Significant histopathological findings included widespread necrotizing vasculitis, non-suppurative meningoencephalitis, lymphocytic interstitial nephritis and hepatitis, and thrombosis. PCR assay performed on DNA extracted from kidney and mesenteric lymph node of one animal amplified a product of 423 base pairs corresponding to a target sequence within the ovine herpesvirus 2 (OVH-2) tegument protein gene. Direct sequencing of the PCR products, from extracted DNA of the kidney and mesenteric lymph node of one cow, amplified the partial nucleotide sequences (423 base pairs) of OVH-2 tegument protein gene. Blast analysis confirmed that these sequences have 98-100% identity with similar OVH-2 sequences deposited in GenBank. Phylogenetic analyses, based on the deduced amino acid sequences, demonstrated that the strain of OVH-2 circulating in ruminants from the Brazilian states of Rio Grande do Norte and Minas Gerais are similar to that identified in other geographical locations. These findings confirmed the active participation of OVH-2 in the classical manifestations of sheep associated malignant catarrhal fever.

scholarly journals Ovine herpesvirus 2 replicates initially in the lung of experimentally infected sheep

2008 ◽  
Vol 89 (7) ◽  
pp. 1699-1708 ◽  
Author(s):  
Hong Li ◽  
Cristina W. Cunha ◽  
Christopher J. Davies ◽  
Katherine L. Gailbreath ◽  
Donald P. Knowles ◽  
...  
Keyword(s):  
Lymphoproliferative Disease ◽  
Infected Sheep ◽  
Open Reading Frame ◽  
Malignant Catarrhal Fever ◽  
Defence Mechanism ◽  
Reading Frame ◽  
Initial Infection ◽  
Nasal Secretions ◽  
Replication Site

Ovine herpesvirus 2 (OvHV-2), a rhadinovirus in the subfamily Gammaherpesvirinae, is the causative agent of sheep-associated malignant catarrhal fever (SA-MCF), a frequently fatal lymphoproliferative disease primarily of ruminants worldwide. Inability to propagate the virus in vitro has made it difficult to study OvHV-2 replication. Aerosol inoculation of sheep with OvHV-2 from nasal secretions collected from naturally infected sheep during shedding episodes results in infection of naive sheep, providing an excellent system to study OvHV-2 initial replication in the natural host. In this study, we showed that OvHV-2 delivered through the nasal route by nebulization resulted in infection in all lambs, but no infection was established in any lambs after intravenous or intraperitoneal injection. In nebulized lambs, while it was not detected initially in any other tissues, OvHV-2 DNA became detectable in the lung at 3 days post-infection (p.i.), increased to about 900 copies per 50 ng DNA at 5 days p.i., reached peak levels (∼7500 copies) at 7 days p.i., and then declined to an average of 800 copies at 9 days p.i. Transcripts of OvHV-2 open reading frame 25 (coding for the capsid protein), an indicator of virus replication, were only detected in lung tissues, and were positively correlated with OvHV-2 DNA levels in the lungs. In addition, selected immune response genes were also highly expressed in the lung at 5 and 7 days p.i. The data indicate that lung is the primary replication site for OvHV-2 during initial infection in sheep and suggest that viral replication is promptly controlled by a host defence mechanism.

scholarly journals Malignant catarrhal fever (Coryza gangraenosa bovum)

2008 ◽  
Vol 62 (1-2) ◽  
pp. 105-110
Author(s):  
Filip Spasojevic ◽  
Djordje Uzelac ◽  
Zlatko Milosavljevic ◽  
Ivan Vujanac
Keyword(s):  
Body Temperature ◽  
Blood Vessels ◽  
Medical Condition ◽  
Malignant Catarrhal Fever ◽  
Lethal Outcome ◽  
Cattle Farm ◽  
Temperature Changes ◽  
Progressive Loss ◽  
Loss Of Weight ◽  
Elevated Body Temperature

Malignant catarrhal fever is a disease of cattle and other ruminants, which most often has a lethal outcome. The disease occurs sporadically and is very difficult to control. At a private mini cattle farm, the occurrence of malignant catarrhal fever was suspected on the grounds of anaemnestic data and results of clinical examinations. The owner said that, in addition to cattle, he also breeds sheep in a separate facility, but said these animals had not been in contact with the diseased cow. In the course of the disease, the characteristic symptoms developed so that the clinical diagnosis set earlier was subsequently confirmed. In addition to constantly elevated body temperature, changes in the eyes were observed very soon (congested blood vessels and capillaries of the white sclera with keratitis on both sides). In addition to photofobia and a copious discharge from the nasal cavities, the discharge was at first seromucous and later became mucopurrulent. In the later course of the disease, there was progressive loss of weight and exhaustion of the animal. Since therapy included, in addition to other medicines, also a glucocorticosteroid preparation, the animal aborted its fetus on the fifth day. A pathological-anatomical examination did not reveal any changes on the fetus. In spite of the applied therapy, the medical condition deteriorated from day to day, and the animal expired on the eighth day of the disease.

Sign in / Sign up

Export Citation Format

Share Document