Tumor cell drug and radiation resistance: Does an interrelationship exist?

1989 ◽  
pp. 189-203 ◽  
Author(s):  
James B. Mitchell ◽  
Angelo Russo ◽  
John A. Cook ◽  
Eli Glatstein
Keyword(s):  
Tumor Cell ◽  
Radiation Resistance

HIF-1α Regulates Radiation Resistance in Primary Sarcomas in a Tumor-Cell Autonomous Mechanism

2014 ◽  
Vol 90 (1) ◽  
pp. S772
Author(s):  
M. Zhang ◽  
Q. Qiu ◽  
H. Min ◽  
Z. Li ◽  
D. Cardona ◽  
...  
Keyword(s):  
Tumor Cell ◽  
Radiation Resistance

scholarly journals Acquired Tumor Cell Radiation Resistance at the Treatment Site Is Mediated Through Radiation-Orchestrated Intercellular Communication

2014 ◽  
Vol 88 (3) ◽  
pp. 677-685 ◽  
Author(s):  
Natarajan Aravindan ◽  
Sheeja Aravindan ◽  
Vijayabaskar Pandian ◽  
Faizan H. Khan ◽  
Satish Kumar Ramraj ◽  
...  
Keyword(s):  
Tumor Cell ◽  
Intercellular Communication ◽  
Radiation Resistance ◽  
Treatment Site

A Molecular Approach to Immunoscintigraphy: A Study of the T-Antigen Conformation on the Surface of Tumors

1987 ◽  
Vol 26 (01) ◽  
pp. 1-6 ◽  
Author(s):  
S. Selvaraj ◽  
M. R. Suresh ◽  
G. McLean ◽  
D. Willans ◽  
C. Turner ◽  
...  
Keyword(s):  
Monoclonal Antibodies ◽  
Tumor Cell ◽  
T Antigen ◽  
Human Carcinomas ◽  
Animal Tumor ◽  
Synthetic Antigens

The role of glycoconjugates in tumor cell differentiation has been well documented. We have examined the expression of the two anomers of the Thomsen-Friedenreich antigen on the surface of human, canine and murine tumor cell membranes both in vitro and in vivo. This has been accomplished through the synthesis of the disaccharide terminal residues in both a and ß configuration. Both entities were used to generate murine monoclonal antibodies which recognized the carbohydrate determinants. The determination of fine specificities of these antibodies was effected by means of cellular uptake, immunohistopathology and immunoscintigraphy. Examination of pathological specimens of human and canine tumor tissue indicated that the expressed antigen was in the β configuration. More than 89% of all human carcinomas tested expressed the antigen in the above anomeric form. The combination of synthetic antigens and monoclonal antibodies raised specifically against them provide us with invaluable tools for the study of tumor marker expression in humans and their respective animal tumor models.

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