Determination of the Pharmacokinetics of 2-Amino-7-Phosphonoheptanoate in Plasma and Cerebrospinal Fluid

1988 ◽  
pp. 219-221 ◽  
Author(s):  
R. P. Compton ◽  
P. A. Kreiter ◽  
R. G. Smith ◽  
R. D. Harken ◽  
J. B. Monahan
Keyword(s):  
Cerebrospinal Fluid

Determination of Melatonin Hormone and Neurotransmitters in Cerebrospinal Fluid: Method Validation and Uncertainty Calculations

2018 ◽  
Vol 73 (6) ◽  
pp. 613-625
Author(s):  
Özge Yetgin Çetin ◽  
Hatice Karadeniz ◽  
Alper Karakaş ◽  
Serpil Yenisoy-Karakaş
Keyword(s):  
Cerebrospinal Fluid ◽  
Method Validation

Resistance to Outflow of Cerebrospinal Fluid Determined by Bolus Injection Technique and Constant Rate Steady State Infusion in Humans

Neurosurgery ◽  
1985 ◽  
Vol 16 (3) ◽  
pp. 336-340 ◽  
Author(s):  
Michael Kosteljanetz
Keyword(s):  
Cerebrospinal Fluid ◽  
Steady State ◽  
Bolus Injection ◽  
Point Of View ◽  
Injection Technique ◽  
Communicating Hydrocephalus ◽  
Constant Rate ◽  
High Degree ◽  
Infusion Technique

Abstract Two methods for the determination of resistance to the outflow of cerebrospinal fluid, the bolus injection technique and the constant rate steady state infusion technique, were compared. Thirty-two patients with a variety of intracranial diseases (usually communicating hydrocephalus) were studied. There was a high degree of correlation between the resistance values obtained with the two methods, but values based on the bolus injection technique were systematically and statistically significantly lower than those obtained with the constant rate infusion test. From a practical point of view. both methods were found to be applicable in a clinical setting.

Microdetermination of Cholesterol and Phospholipid in Cerebrospinal Fluid and Serum by Silicic Acid Column Chromatography

1962 ◽  
Vol 8 (6) ◽  
pp. 598-605 ◽  
Author(s):  
Yung S Shin ◽  
James C Lee
Keyword(s):  
Cerebrospinal Fluid ◽  
Human Serum ◽  
Total Phosphorus ◽  
Silicic Acid ◽  
Column Chromatography ◽  
Silicic Acid Column ◽  
Lipid Phosphorus ◽  
Silicic Acid Column Chromatography ◽  
Phospholipid Ratio

Abstract A method is presented for the determination of cholesterol and phospholipid, which requires 5 µl. of human serum or 1-2 ml. of cerebrospinal fluids. With this method 5-100 µg. of cholesterol and phospholipid can be separated by a modified silicic acid column after elution of the mixture with 1 ml. of chloroform and 3 ml. of methanol. Recovery for 24.6 µg. of cholesterol and 30.5 µg. of phospholipid was 98.4 and 96.7%, respectively. Standard deviations of ± 1.73 and ± 1.24 have been obtained for the reproducibility of cholesterol and phospholipid determinations after chromatography. The method has been applied for the estimation of the cholesterol/phospholipid ratio and of lipid phosphorus in total phosphorus of human cerebrospinal fluids.

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