Longitudinal (Natural History) Studies of Silent Myocardial Ischemia

AbstractA recent report on long-term dietary mannose supplementation in phosphomannomutase 2 deficiency (PMM2-CDG) claimed improved glycosylation and called for double-blind randomized study of the dietary supplement in PMM2-CDG patients. A lack of efficacy of short-term mannose supplementation in multiple prior reports challenge this study’s conclusions. Additionally, some CDG types have previously been reported to demonstrate spontaneous improvement in glycosylated biomarkers, including transferrin. We have likewise observed improvements in transferrin glycosylation without mannose supplementation. This observation questions the reliability of transferrin as a therapeutic outcome measure in clinical trials for PMM2-CDG. We are concerned that renewed focus on mannose therapy in PMM2-CDG will detract from clinical trials of more promising therapies. Approaches to increase efficiency of clinical trials and ultimately improve patients’ lives requires prospective natural history studies and identification of reliable biomarkers linked to clinical outcomes in CDG. Collaborations with patients and families are essential to identifying meaningful study outcomes.

Download Full-text

Silent myocardial ischemia during ambulatory electrocardiographic monitoring in patients with effort angina

Journal of the American College of Cardiology ◽

10.1016/s0735-1097(83)80213-7 ◽

1983 ◽

Vol 1 (3) ◽

pp. 934-939 ◽

Cited By ~ 251

Author(s):

Antonio C. Cecchi ◽

Emilio V. Dovellini ◽

Francesco Marchi ◽

Paolo Pucci ◽

Giovanni M. Santoro ◽

...

Keyword(s):

Myocardial Ischemia ◽

Silent Myocardial Ischemia ◽

Effort Angina ◽

Electrocardiographic Monitoring

Download Full-text

Potential for Real-Time Processing of the Continuously Monitored Electrocardiogram in the Detection, Quantitation, and Intervention of Silent Myocardial Ischemia

Cardiology Clinics ◽

10.1016/s0733-8651(18)30593-9 ◽

1986 ◽

Vol 4 (4) ◽

pp. 735-745 ◽

Cited By ~ 21

Author(s):

Richard I. Levin ◽

David Cohen ◽

William Frisbie ◽

Andrew P. Selwyn ◽

Joan Barry ◽

...

Keyword(s):

Myocardial Ischemia ◽

Real Time ◽

Silent Myocardial Ischemia ◽

Real Time Processing ◽

Time Processing

Download Full-text

An Imaging Approach to Deep Vein Thrombosis and the Lower Extremity Thrombosis Classification

Phlebology The Journal of Venous Disease ◽

10.1258/phleb.2012.012s25 ◽

2012 ◽

Vol 27 (1_suppl) ◽

pp. 143-148 ◽

Cited By ~ 22

Author(s):

C W K P Arnoldussen ◽

C H A Wittens

Keyword(s):

Clinical Trials ◽

Deep Vein Thrombosis ◽

Natural History ◽

Lower Extremity ◽

Systematic Approach ◽

Vein Thrombosis ◽

Natural History Studies ◽

Imaging Approach ◽

Deep Vein

In this article we want to discuss the potential of lower extremity deep vein thrombosis (DVT) imaging and propose a systematic approach to DVT management based on a DVT classification of the lower extremity; the LET classification. Identifying and reporting DVT more systematically allows for accurate stratification for initial patient care, future clinical trials and appropriate descriptions for natural history studies.

Download Full-text