The Importance of Autonomic Innervation of the Heart in the Genesis of Cardiac Arrhythmias

Topics in the Neurosciences - Neuroregulation of Autonomic, Endocrine and Immune Systems ◽

10.1007/978-1-4613-2315-0_10 ◽

1986 ◽

pp. 199-220

Author(s):

Douglas P. Zipes ◽

Michael J. Barber ◽

Nobuhiro Takahashi ◽

Robert F. Gilmour

Keyword(s):

Cardiac Arrhythmias ◽

Autonomic Innervation

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Sleep and cardiac arrhythmias

Archives of Internal Medicine ◽

10.1001/archinte.130.5.751 ◽

1972 ◽

Vol 130 (5) ◽

pp. 751-753 ◽

Cited By ~ 13

Author(s):

R. Smith

Keyword(s):

Cardiac Arrhythmias

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Cardiac arrhythmias: MicroRNA beating the heart

Nature China ◽

10.1038/nchina.2007.282 ◽

2007 ◽

Author(s):

John Fox

Keyword(s):

Cardiac Arrhythmias

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Cardiac arrhythmias related to psychiatric medication

Nervenheilkunde ◽

10.1055/s-0038-1627522 ◽

2017 ◽

Vol 36 (09) ◽

pp. 747-750

Author(s):

R. W. Freudenmann ◽

C. Schönfeldt-Lecuona ◽

B. J. Connemann ◽

M. Gahr ◽

M. Elsayed

Keyword(s):

Cardiac Arrhythmias ◽

Torsade De Pointes ◽

General Medicine ◽

Fold Increase ◽

Cardiac Risk ◽

Psychiatric Medication ◽

Cardiac Side Effects ◽

Torsade De Pointes Tachycardia ◽

Multiple Drugs ◽

Available Information

SummaryThis narrative review summarizes current available information about cardiac arrhythmias (QT prolongation, Torsade de pointes Tachycardia [TdP], sudden cardiac death) associated with psychiatric medication. Among the most commonly used antipsychotics, amisulpride and ziprasidone are most frequently associated with TdP. Treatment with some antidepressants (SSRIs, tricyclic antidepressants) is associated with a 5- to 6-fold increase in the incidence of out-of-hospital cardiac arrest. Lithium is associated with bradycardia, T-wave changes and AV-block; anxiolytics of the benzodiazepine group do usually not have cardiac side effects. The combination of multiple drugs (including medications from general medicine) that prolong the QT interval has a particularly high cardiac risk.

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Entrainment and Annihilation of Reentrant Excitation in a Periodically Stimulated Ring of Excitable Media

Methods of Information in Medicine ◽

10.1055/s-0038-1636861 ◽

1997 ◽

Vol 36 (04/05) ◽

pp. 290-293

Author(s):

L. Glass ◽

T. Nomura

Keyword(s):

Cardiac Arrhythmias ◽

Initial Phase ◽

Human Heart ◽

Periodic Wave ◽

Excitable Media ◽

One Dimensional ◽

Clinical Observations ◽

Periodic Stimulation ◽

Reentrant Excitation ◽

Stimulation Of

Abstract:Excitable media, such as nerve, heart and the Belousov-Zhabo- tinsky reaction, exhibit a large excursion from equilibrium in response to a small but finite perturbation. Assuming a one-dimensional ring geometry of sufficient length, excitable media support a periodic wave of circulation. As in the periodic stimulation of oscillations in ordinary differential equations, the effects of periodic stimuli of the periodically circulating wave can be described by a one-dimensional Poincaré map. Depending on the period and intensity of the stimulus as well as its initial phase, either entrainment or termination of the original circulating wave is observed. These phenomena are directly related to clinical observations concerning periodic stimulation of a class of cardiac arrhythmias caused by reentrant wave propagation in the human heart.

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