Pathogenesis of the Intestinal Phase of the Graft-Versus-Host Reaction inn F1 Hybrid Mice

1985 ◽  
pp. 531-538
Author(s):  
Allan McI. Mowat ◽  
Annette Borland ◽  
Delphine M. V. Parrott
Keyword(s):  
Graft Versus Host Reaction ◽  
Host Reaction ◽  
F1 Hybrid ◽  
Graft Versus Host ◽  
Intestinal Phase ◽  
Hybrid Mice

scholarly journals Brief Report: Graft-Versus-Host Reaction in F1 Hybrid Mice Injected with Pre-Immunized Parental Thymus Cells

Blood ◽  
1964 ◽  
Vol 24 (6) ◽  
pp. 770-774 ◽  
Author(s):  
LUCIANO FIORE-DONATI ◽  
LUIGI CHIECO-BIANCHI ◽  
GIUSEPPE DE BENEDICTIS ◽  
GIUSEPPE TRIDENTE
Keyword(s):  
Lymphoid Cells ◽  
The Other ◽  
F1 Hybrids ◽  
Graft Versus Host Reaction ◽  
Host Reaction ◽  
F1 Hybrid ◽  
Graft Versus Host ◽  
Immunologic Activity ◽  
Thymus Cells ◽  
Hybrid Mice

Abstract Dissociated thymus cells are capable of initiating graft-versus-host reaction in (C3Hf/Gs x DBA/2)F1 hybrids only when derived from parental donors previously sensitized against the antigens of the other parental strain. The lower immunologic activity of thymus cells as compared with other lymphoid cells is presumably due to quantitative rather than qualitative differences in immunologically competent cells.

Graft-versus-host reaction in F1 hybrid mice injected with pre-immunised parental thymus cells

1965 ◽  
Vol 3 (3) ◽  
pp. 456
Author(s):  
L. Fiore-Donati ◽  
L. Chieco-Bianchi ◽  
de Benedictis ◽  
G. Tridente
Keyword(s):  
Graft Versus Host Reaction ◽  
Host Reaction ◽  
F1 Hybrid ◽  
Graft Versus Host ◽  
Thymus Cells ◽  
Hybrid Mice

scholarly journals Expression of endogenous murine leukemia viruses during the course of a protracted immunological disorder.

1977 ◽  
Vol 145 (4) ◽  
pp. 1060-1065 ◽  
Author(s):  
M Y Armstrong ◽  
N H Ruddle ◽  
F F Richards
Keyword(s):  
Murine Leukemia Virus ◽  
Leukemia Virus ◽  
Graft Versus Host Reaction ◽  
Host Reaction ◽  
F1 Hybrid ◽  
Graft Versus Host ◽  
Endogenous Viruses ◽  
Immunological Disorder ◽  
Leukemia Viruses ◽  
Murine Leukemia

Mice of the low leukemia (BALB/cJ x A/J)F1 hybrid (CAF1) strain express B-and N-tropic infectious murine leukemia virus (MuLV) after the age of 6 mo. Initation of a protracted immunological disorder, the graft-versus-host reaction (GVHR), at 7 wk of age, accelerates the induction of both these mouse-tropic endogenous viruses, and preferentially enhances the replication of B-tropic MuLV. The earlier appearance of B-tropic MuLV in a greater proportion of mice and in higher titer is thought to be casually related to the eventual development of lymphoreticular tumors in the GVHR mice, since previous studies have shown that these same tumors can be reproduced by inoculating syngeneic recipients with serially passaged GVHR extracts containing B-tropic MuLV.

scholarly journals THE INTERACTION OF DONOR AND HOST LYMPHOID CELLS IN THE PATHOGENESIS OF RENAL CORTICAL DESTRUCTION INDUCED BY A LOCAL GRAFT VERSUS HOST REACTION

1966 ◽  
Vol 123 (1) ◽  
pp. 103-118 ◽  
Author(s):  
William L. Elkins
Keyword(s):  
Host Cells ◽  
Whole Body ◽  
Graft Versus Host Reaction ◽  
Developmental Phase ◽  
Donor Strain ◽  
Spleen Cells ◽  
Host Reaction ◽  
F1 Hybrid ◽  
Graft Versus Host ◽  
Donor Type

The graft versus host reaction (GVHR), which results from the injection of parental strain spleen cells beneath the kidney capsule of F1 hybrid rats, is transferable during its developmental phase into F1 hybrid hosts isogeneic with the primary host, but not into secondary hosts of the parental (donor) strain. Furthermore, the GVHR propagates but rarely in secondary hybrid hosts which are allogeneic with respect to the primary hosts, but which are also genetically tolerant of donor-type cells. These findings indicate that the donor cells not only initiate the GVHR but also maintain it by virtue of immunologically specific activity. Whole-body irradiation of (LBf)F1 and (LBN)F1 hosts 24 hours prior to the injection of parental (L) spleen cells results in inhibition of the subsequent GVHR to a degree commensurate with the radiation damage sustained by the lymphoid system of the host. Furthermore, propagation of transferred GVHRs did not occur if susceptible secondary hybrid hosts had been previously irradiated. These findings indicate that radiosensitive host cells play a continuing and essential role in the pathogenesis of the invasive-destructive lesion. It is concluded that the development of this lesion depends upon the continuous interaction of the specifically reactive donor-type cells with an immunologically non-specific population of host mononuclears.

Effect of the graft-versus-host reaction on the immunological responsiveness of the mouse

1961 ◽  
Vol 154 (957) ◽  
pp. 532-539 ◽  
Keyword(s):  
Graft Versus Host Reaction ◽  
Bacterial Antigen ◽  
Spleen Cells ◽  
Host Reaction ◽  
Graft Versus Host ◽  
Loss Of Weight ◽  
Immunological Reactions ◽  
First Time ◽  
Hybrid Mice ◽  
Special Case

Graft-versus-host reaction has been induced in unirradiated adult ( C 57 BL x CBA ) F 1 hybrid mice by intravenous injection of parent-line spleen cells, and the capacity of the injected animals to react to first-set and second-set grafts of A -line skin, and to Salm. typhi H antigen, has been investigated. Injection of CBA cells resulted in little or no loss of weight, a low mortality, little or no impairment of the recipient’s capacity to react to A skin or to the bacterial antigen when encountered for the first time, and no loss of pre-existing immunity to A skin. Injection of (40 to 100) x 10 6 C 57 BL cells on the other hand resulted in severe loss of weight and diarrhoea, often culminating in death. Surviving non-immunized animals reacted feebly to the bacterial antigen and some were slower than normal in rejecting first-set grafts of A skin. Pre-existing immunity to A skin was lost except in the special case when the spleen cell donor had itself been immunized against A skin. It is concluded that severe graft-versus-host reaction depresses the host’s immunological reactivity, but that the foreign cells may enable the host to muster a variety of immunological reactions by proxy.

Sign in / Sign up

Export Citation Format

Share Document