Antimicrobial Medical Devices in Preclinical Development and Clinical Use

2012 ◽  
pp. 307-354 ◽  
Author(s):  
Benjamin D. Brooks ◽  
Amanda E. Brooks ◽  
David W. Grainger
Keyword(s):  
Medical Devices ◽  
Clinical Use ◽  
Preclinical Development

scholarly journals A protocol for a systematic review investigating the factors influencing the statistical planning, design, conduct, analysis and reporting of trials

2020 ◽  
Vol 3 ◽  
pp. 36
Author(s):  
Marina Zaki ◽  
Marie Galligan ◽  
Lydia O'Sullivan ◽  
Declan Devane ◽  
Eilish McAuliffe
Keyword(s):  
Systematic Review ◽  
Medical Devices ◽  
Methodological Approach ◽  
Clinical Use ◽  
Key Factors ◽  
Eligibility Criteria ◽  
Factors Influencing ◽  
Comprehensive Search ◽  
Statistical Planning

Trials can be defined as prospective human research studies to test the effectiveness and safety of interventions, such as medications, surgeries, medical devices and other interventions for the management of patient care. Statistics is an important and powerful tool in trials. Inappropriately designed trials and/or inappropriate statistical analysis produce unreliable results, with limited clinical use. The aim of this systematic literature review is to identify, describe and synthesise factors contributing to or influencing the statistical planning, design, conduct, analysis and reporting of trials. This protocol will describe the methodological approach taken for the following: conducting a systematic and comprehensive search for relevant articles, applying eligibility criteria for the inclusion of such articles, extracting data and information, appraising the quality of the articles, and thematically synthesizing the data to illuminate the key factors influencing statistical aspects of trials.

Clinical Use Of Medical Devices In The ‘Bermuda Triangle’

2004 ◽  
Vol 23 (1) ◽  
pp. 200-207 ◽  
Author(s):  
Larry Kessler ◽  
Scott D. Ramsey ◽  
Sean Tunis ◽  
Sean D. Sullivan
Keyword(s):  
Medical Devices ◽  
Clinical Use

scholarly journals Bacterial Interactions with Dental and Medical Materials

2020 ◽  
Vol 11 (4) ◽  
pp. 83
Author(s):  
Mary Anne Melo
Keyword(s):  
Medical Devices ◽  
Scientific Understanding ◽  
Clinical Use ◽  
Oral Diseases ◽  
Bacterial Interactions ◽  
Medical Materials

Fundamental scientific understanding of oral diseases associated with tissue-contacting dental and medical devices is primordial to facilitate pathways for their translation to clinical use [...]

scholarly journals Primena digitalne video tehnike u ortopediji

2006 ◽  
Vol 53 (4) ◽  
pp. 99-104
Author(s):  
C. Vucetic ◽  
D. Milovanovic ◽  
B. Dulic ◽  
I. Dimitrijevic ◽  
N. Kalezic ◽  
...  
Keyword(s):  
Medical Devices ◽  
Digital Imaging ◽  
Digital Images ◽  
Digital Technologies ◽  
Surgical Patient ◽  
Clinical Use ◽  
Digital Imaging Technology ◽  
Case Documentation ◽  
Care Information

Digital video technologies are new and powerful tools with wide applications in orthopedic. Already integral to several common medical devices, digital images can be used for case documentation and presentation as well for diagnostic and surgical patient care information. Digital technologies allow easy manipulation of photographic, video and graphic materials in ways that were impossible with conventional techniques. Educational presentation has been transformed by use of computers and digital projectors. Understanding the basic foundations of digital imaging technology is important for effectively creating digital images, videos and presentations. In this review, we are going to discuss some of the issues that are raised by digital imaging in orthopedics, digital image processing, as well as, we are giving some recommendations for good quality of pre-, post- and intra-operative photographs in clinical use.

scholarly journals A protocol for a systematic review investigating the factors influencing the statistical planning, design, conduct, analysis and reporting of clinical trials

2020 ◽  
Vol 3 ◽  
pp. 36
Author(s):  
Marina Zaki ◽  
Marie Galligan ◽  
Lydia O'Sullivan ◽  
Declan Devane ◽  
Eilish McAuliffe
Keyword(s):  
Clinical Trials ◽  
Medical Devices ◽  
Methodological Approach ◽  
Clinical Use ◽  
Key Factors ◽  
Eligibility Criteria ◽  
Factors Influencing ◽  
Comprehensive Search ◽  
Statistical Planning

Clinical trials can be defined as prospective human research studies to test the effectiveness and safety of interventions, such as medications, surgeries, medical devices and other interventions for the management of patient care. Statistics is an important and powerful tool in clinical trials. Inappropriately designed trials and/or inappropriate statistical analysis produce unreliable results, with limited clinical use. The aim of this systematic literature review is to identify, describe and synthesise factors contributing to or influencing the statistical planning, design, conduct, analysis and reporting of clinical trials. This protocol will describe the methodological approach taken for the following: conducting a systematic and comprehensive search for relevant articles, applying eligibility criteria for the inclusion of such articles, extracting data and information, appraising the quality of the articles, and thematically synthesizing the data to illuminate the key factors influencing statistical aspects of clinical trials.

scholarly journals Update on Preclinical Development and Clinical Translation of Cholecystokinin-2 Receptor Targeting Radiopharmaceuticals

Cancers ◽  
2021 ◽  
Vol 13 (22) ◽  
pp. 5776
Author(s):  
Elisabeth von Guggenberg ◽  
Petra Kolenc ◽  
Christof Rottenburger ◽  
Renata Mikołajczak ◽  
Alicja Hubalewska-Dydejczyk
Keyword(s):  
Clinical Trials ◽  
Radionuclide Therapy ◽  
Medullary Thyroid Cancer ◽  
Clinical Results ◽  
Targeted Imaging ◽  
Clinical Use ◽  
Targeted Radionuclide Therapy ◽  
Imaging Studies ◽  
Preclinical Development ◽  
Medullary Thyroid

The cholecystokinin-2 receptor (CCK2R) has been a target of interest for molecular imaging and targeted radionuclide therapy for two decades. However, so far CCK2R targeted imaging and therapy has not been introduced in clinical practice. Within this review the recent radiopharmaceutical development of CCK2R targeting compounds and the ongoing clinical trials are presented. Currently, new gastrin derivatives as well as nonpeptidic substances are being developed to improve the properties for clinical use. A team of specialists from the field of radiopharmacy and nuclear medicine reviewed the available literature and summarized their own experiences in the development and clinical testing of CCK2R targeting radiopharmaceuticals. The recent clinical trials with novel radiolabeled minigastrin analogs demonstrate the potential for both applications, imaging as well as targeted radiotherapy, and reinforce the clinical applicability within a theranostic concept. The intense efforts in optimizing CCK2R targeting radiopharmaceuticals has led to new substances for clinical use, as shown in first imaging studies in patients with advanced medullary thyroid cancer. The first clinical results suggest that the wider clinical implication of CCK2R-targeted radiopharmaceuticals is reasonable.

scholarly journals An industrial oriented workflow for 3D printed, patient specific orthopedic cast

2021 ◽  
Vol 3 (11) ◽  
Author(s):  
Mario Formisano ◽  
Luigi Iuppariello ◽  
Antonio Casaburi ◽  
Pasquale Guida ◽  
Fabrizio Clemente
Keyword(s):  
Clinical Practice ◽  
Medical Device ◽  
Medical Devices ◽  
Quality Standards ◽  
Patient Specific ◽  
Clinical Use ◽  
Production Flow ◽  
Medical Device Design ◽  
Voluntary Standards ◽  
3D Printed

AbstractThe clinical use of 3D printed patient specific orthopaedic cast is of wide interest. However, design and production have problems such as production time, which can take up to 35 h, and standardized procedure considering that there are medical devices that must comply mandatory and/or voluntary standards. Moreover, the proposed procedures do not fully consider the traceability of this innovative medical device design to comply with standards and industrial proposes. The aim of this work is to propose a semi-automatic workflow for the production of the 3D printed orthopaedic casts. The procedure is oriented towards a reduction time in different phases (as scan setting, designing technique, printing orientation) of the production flow. The workflow is compliant with recognized quality standards for the production of additive manufactured medical devices. This approach offers the possibility to introduce new 3D printed medical devices in clinical practice as well as to design an optimized industrial workflow.

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