Screening for Cervical Cancer in Low-Resource Countries

2013 ◽  
pp. 99-123
Author(s):  
Laurie Elit
Keyword(s):  
2017 ◽  
Vol 6 (8) ◽  
pp. 2008-2014 ◽  
Author(s):  
Nicole G. Campos ◽  
Vivien Tsu ◽  
Jose Jeronimo ◽  
Mercy Mvundura ◽  
Jane J. Kim

2015 ◽  
Vol 19 (4) ◽  
pp. 295-300 ◽  
Author(s):  
Dominique Ricard-Gauthier ◽  
Anna Wisniak ◽  
Rosa Catarino ◽  
Annabelle Faure van Rossum ◽  
Ulrike Meyer-Hamme ◽  
...  

2010 ◽  
Vol 20 (5) ◽  
pp. 862-868 ◽  
Author(s):  
Pakhee Aggarwal ◽  
Swaraj Batra ◽  
Gauri Gandhi ◽  
Vijay Zutshi

Objectives:To compare the sensitivity, specificity, positive and negative predictive values, and accuracy of Papanicolaou test with visual inspection with acetic acid (VIA)/VIA using magnification devices (VIAM) and develop the best strategy for screening in low resource settings.Materials and Methods:This is a prospective cross-sectional study on 408 symptomatic multiparous women in the reproductive age group, sequentially using the Papanicolaou test, the VIA, and the VIAM for screening. Women with a positive screening test underwent guided biopsy and endocervical curettage. The site of biopsy was recorded. Histopathological findings were taken as the "gold" standard in comparing the methods.Results:The mean (SD) age was 32.3 (6.8) years (range, 15-49 years), whereas the mean (SD) parity was 2.9 (1.2) (range, 1-9). Abnormal cytological findings were detected in 2.9% patients, whereas the remaining smears were negative for any intraepithelial lesion or malignancy. A total of 113 cases were screened positive by one/all methods. The sensitivity, specificity, positive predictive value, negative predictive value, and accuracy of the Papanicolaou test, the VIA, and the VIAM were 24, 98, 42, 96, and 94%; 95, 78, 19, 99, and 79%; and 95, 78, 19, 99, and 79%, respectively, for high-grade lesions.Conclusions:The Papanicolaou test had low sensitivity but high specificity, whereas visual detection methods had a high sensitivity in addition to being cheaper. Alternative methods of screening such as VIA/VIAM can be a valuable alternative to the Papanicolaou test for cervical cancer screening in low resource settings. Visual inspection using magnification devices may be of benefit over VIA in doubtful cases.


2001 ◽  
Vol 72 (1) ◽  
pp. 47-53 ◽  
Author(s):  
P.D. Blumenthal ◽  
L. Gaffikin ◽  
Z.M. Chirenje ◽  
J. McGrath ◽  
S. Womack ◽  
...  

2019 ◽  
pp. 1-9
Author(s):  
Kelly Kisling ◽  
Lifei Zhang ◽  
Hannah Simonds ◽  
Nazia Fakie ◽  
Jinzhong Yang ◽  
...  

Purpose The purpose of this study was to validate a fully automatic treatment planning system for conventional radiotherapy of cervical cancer. This system was developed to mitigate staff shortages in low-resource clinics. Methods In collaboration with hospitals in South Africa and the United States, we have developed the Radiation Planning Assistant (RPA), which includes algorithms for automating every step of planning: delineating the body contour, detecting the marked isocenter, designing the treatment-beam apertures, and optimizing the beam weights to minimize dose heterogeneity. First, we validated the RPA retrospectively on 150 planning computed tomography (CT) scans. We then tested it remotely on 14 planning CT scans at two South African hospitals. Finally, automatically planned treatment beams were clinically deployed at our institution. Results The automatically and manually delineated body contours agreed well (median mean surface distance, 0.6 mm; range, 0.4 to 1.9 mm). The automatically and manually detected marked isocenters agreed well (mean difference, 1.1 mm; range, 0.1 to 2.9 mm). In validating the automatically designed beam apertures, two physicians, one from our institution and one from a South African partner institution, rated 91% and 88% of plans acceptable for treatment, respectively. The use of automatically optimized beam weights reduced the maximum dose significantly (median, −1.9%; P < .001). Of the 14 plans from South Africa, 100% were rated clinically acceptable. Automatically planned treatment beams have been used for 24 patients with cervical cancer by physicians at our institution, with edits as needed, and its use is ongoing. Conclusion We found that fully automatic treatment planning is effective for cervical cancer radiotherapy and may provide a reliable option for low-resource clinics. Prospective studies are ongoing in the United States and are planned with partner clinics.


2020 ◽  
Vol 149 (2) ◽  
pp. 254-254
Author(s):  
Sean Kehoe ◽  
Neerja Bhatla ◽  

2019 ◽  
Vol 28 ◽  
pp. 71-75 ◽  
Author(s):  
Vincent DeGennaro ◽  
Madelyn Shafer ◽  
Meagan Kelly ◽  
Jean Ronald Cornely ◽  
Joseph Bernard

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