Mouse Models of Pancreatic Ductal Adenocarcinoma

2013 ◽  
pp. 145-170 ◽  
Author(s):  
Filip Bednar ◽  
Marina Pasca di Magliano
Keyword(s):  
Pancreatic Ductal Adenocarcinoma ◽  
Mouse Models ◽  
Ductal Adenocarcinoma

scholarly journals Preclinical mouse models for immunotherapeutic and non-immunotherapeutic drug development for pancreatic ductal adenocarcinoma

2020 ◽  
Vol 3 ◽  
pp. 7-7
Author(s):  
Mengni He ◽  
MacKenzie Henderson ◽  
Stephen Muth ◽  
Adrian Murphy ◽  
Lei Zheng
Keyword(s):  
Drug Development ◽  
Pancreatic Ductal Adenocarcinoma ◽  
Mouse Models ◽  
Ductal Adenocarcinoma

scholarly journals MiR-142-3p is downregulated in aggressive p53 mutant mouse models of pancreatic ductal adenocarcinoma by hypermethylation of its locus

2018 ◽  
Vol 9 (6) ◽  
Author(s):  
Jack D. Godfrey ◽  
Jennifer P. Morton ◽  
Ania Wilczynska ◽  
Owen J. Sansom ◽  
Martin D. Bushell
Keyword(s):  
Pancreatic Ductal Adenocarcinoma ◽  
Mouse Models ◽  
Mutant Mouse ◽  
Ductal Adenocarcinoma

Coaxing cancer control by modulating COX-2

2019 ◽  
Vol 11 (497) ◽  
pp. eaax9566 ◽  
Author(s):  
Rajan P. Kulkarni
Keyword(s):  
Pancreatic Ductal Adenocarcinoma ◽  
Mouse Models ◽  
Cancer Control ◽  
Cyclooxygenase 2 ◽  
Ductal Adenocarcinoma ◽  
Cox 2

Mouse models of pancreatic ductal adenocarcinoma respond to immunotherapy when given in combination with the cyclooxygenase-2 inhibitor celecoxib.

Cell Type of Pancreatic Ductal Adenocarcinoma Origin: Implications for Prognosis and Clinical Outcomes

2021 ◽  
pp. 1-6
Author(s):  
Shilpa Patil ◽  
Yan Dou ◽  
Janel L. Kopp
Keyword(s):  
Pancreatic Ductal Adenocarcinoma ◽  
Mouse Models ◽  
Pancreatic Injury ◽  
Genetically Engineered ◽  
Ductal Adenocarcinoma ◽  
Cell Of Origin ◽  
Cell Type ◽  
Genetically Engineered Mouse Models ◽  
Cellular Origin ◽  
Ductal Cells

<b><i>Background:</i></b> Pancreatic ductal adenocarcinoma (PDAC) is a devastating disease that has no effective early detection method or treatment to date. <b><i>Summary:</i></b> The normal cell type that initiates PDAC, or its cellular origin, is still unknown. To investigate the contribution of distinct normal epithelial cell types to PDAC tumorigenesis, genetically engineered mouse models were used to show that both acinar and ductal cells are capable of giving rise to PDAC. These studies indicated that genetic mutations and pancreatic injury interact differently with each cellular origin to affect their predilection and process for forming PDAC. In this review, we summarize recent findings using various genetically engineered mouse models in the identification and characterization of the PDAC cell of origin. We also discuss potential implications for cellular origin on tumor development, PDAC transcriptional subtype, and disease prognosis of patients. <b><i>Key Message:</i></b> Although it is clear that both ductal and acinar cells have the potential to form PDAC, whether cellular origin can indeed influence patient prognosis and whether knowledge of cellular origin will aid in the diagnosis or treatment of patients in the future will need further study.

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