Biodegradable Polymers for Focal Delivery Systems

2013 ◽  
pp. 3-32 ◽  
Author(s):  
Wahid Khan ◽  
Venu Gopala Swami Challa ◽  
Robert Langer ◽  
Abraham J. Domb
Keyword(s):  
Biodegradable Polymers ◽  
Delivery Systems

Biodegradable Polymers for Protein and Peptide Therapeutics: Next Generation Delivery Systems

2017 ◽  
pp. 483-541
Author(s):  
Sathish Dyawanapelly ◽  
Nishant Kumar Jain ◽  
Sindhu KR ◽  
Maruthi Prasanna ◽  
Akhilesh Vikram Singh
Keyword(s):  
Biodegradable Polymers ◽  
Delivery Systems ◽  
Next Generation ◽  
Peptide Therapeutics

FROM PLASTICS TO ADVANCED POLYMER IMPLANTS: THE ESSENTIALS OF POLYMER CHEMISTRY

COSMOS ◽  
2008 ◽  
Vol 04 (01) ◽  
pp. 1-15 ◽  
Author(s):  
JOACHIM SAY CHYE LOO
Keyword(s):  
Drug Delivery ◽  
Tissue Engineering ◽  
Biodegradable Polymers ◽  
Human Body ◽  
Water Purification ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Polymer Chemistry ◽  
Biomedical Implants ◽  
Polymer Implants

Man has been using plastics for thousands of years, and some of the earlier uses of plastics include spoons, buttons and combs. Today, plastics are used for a myriad of applications, such as for aerospace, microelectronics and water purification. With polymer chemistry, man has been able to alter the properties of plastics or polymers to suit almost any application. Their properties can also be tailored for use as advanced biomedical implants in the human body. An example of such a polymer is the biocompatible lactide/glycolide polyesters. These biodegradable polymers are currently used as sutures, drug delivery systems, temporary implants and even as scaffolds for tissue engineering.

NANOMEDICINES: DELIVERING DRUGS USING BOTTOM UP NANOTECHNOLOGY

2005 ◽  
Vol 04 (05n06) ◽  
pp. 855-861 ◽  
Author(s):  
MARTIN GARNETT
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Biodegradable Polymers ◽  
Drug Loading ◽  
Dna Delivery ◽  
Delivery Systems ◽  
The Body ◽  
Nanosized Materials

The use of nanosized materials changes the way in which drugs are handled by the body and offers opportunities to improve drug delivery. The physiological mechanisms controlling the distribution of nanosized materials (enhanced permeability and retention effect, cellular uptake pathways and opsonisation/elimination of nanoparticles) are described. Two different nanosized drug delivery systems are considered; drug delivery and DNA delivery. The deficiencies of currently available biodegradable polymers for preparation of drug containing nanoparticles are mainly the amount of drug that can be incorporated and the rapid rate of drug release. The development of new biodegradable polymers which can interact with the drug and so significantly increase drug loading and decrease the rate of drug release are outlined. DNA delivery necessitates overcoming a variety of biological barriers. We are developing polyelectrolyte complexes of DNA with cationic polyamidoamines (PAA) as a delivery system. Complexing PAA with DNA results in good transfection of cells in vitro. However, in vivo, a more complex arrangement of PAA, Polyethylene glycol-PAA copolymers, DNA and the use of ligands will be required. Despite these efforts, further developments will be needed in nanotechnology for both drug and DNA nanoparticle delivery systems to achieve our clinical objectives.

New biodegradable polymers for injectable drug delivery systems

1999 ◽  
Vol 62 (1-2) ◽  
pp. 109-114 ◽  
Author(s):  
B. Jeong ◽  
Y.K. Choi ◽  
Y.H. Bae ◽  
G. Zentner ◽  
S.W. Kim
Keyword(s):  
Drug Delivery ◽  
Biodegradable Polymers ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Injectable Drug
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