Evolution of the membrane guanylate cyclase transduction system

2002 ◽  
pp. 3-30 ◽  
Author(s):  
Rameshwar K. Sharma
Keyword(s):  
Guanylate Cyclase ◽  
Membrane Guanylate Cyclase

scholarly journals Impairment of the Rod Outer Segment Membrane Guanylate Cyclase Dimerization in A Cone−Rod Dystrophy Results in Defective Calcium Signaling†

Biochemistry ◽  
2000 ◽  
Vol 39 (41) ◽  
pp. 12522-12533 ◽  
Author(s):  
Teresa Duda ◽  
Venkateswar Venkataraman ◽  
Anna Jankowska ◽  
Christian Lange ◽  
Karl-W. Koch ◽  
...  
Keyword(s):  
Calcium Signaling ◽  
Guanylate Cyclase ◽  
Outer Segment ◽  
Membrane Guanylate Cyclase ◽  
Rod Outer Segment

scholarly journals Calcium-Modulated Rod Outer Segment Membrane Guanylate Cyclase Type 1 Transduction Machinery in the Testes

2006 ◽  
Vol 28 (1) ◽  
pp. 50-58 ◽  
Author(s):  
A. Jankowska ◽  
B. Burczynska ◽  
T. Duda ◽  
J. B. Warchol ◽  
R. K. Sharma
Keyword(s):  
Guanylate Cyclase ◽  
Outer Segment ◽  
Membrane Guanylate Cyclase ◽  
Rod Outer Segment

Inhibition of human neutrophil beta2-integrin-dependent adherence by hyperbaric O2

1997 ◽  
Vol 272 (3) ◽  
pp. C770-C777 ◽  
Author(s):  
S. R. Thom ◽  
I. Mendiguren ◽  
K. Hardy ◽  
T. Bolotin ◽  
D. Fisher ◽  
...  
Keyword(s):  
Guanylate Cyclase ◽  
Human Neutrophil ◽  
Animal Studies ◽  
Surface Expression ◽  
Cell Surface Expression ◽  
Human Neutrophils ◽  
Membrane Guanylate Cyclase ◽  
Binding Studies ◽  
Beta2 Integrins ◽  
Cell Fractions

Animal and clinical investigations have reported that exposure to hyperbaric O(2) improved the outcome of some reperfusion injuries. Animal studies have suggested that this may be due to an inhibition of leukocyte adherence to injured endothelium. This investigation tested the hypothesis that exposure to hyperbaric O(2) would inhibit beta2-integrin-dependent adherence of human neutrophils. Subjects were exposed to O(2) at partial pressures of up to 3 atmospheres absolute (ATA; 1 ATA = 0.1 MPa) for 45 min, and neutrophil binding to nylon columns and to fibrinogen-coated surfaces was measured. Exposure to O(2) at 2.8 or 3.0 ATA inhibited beta2-integrin-dependent neutrophil adherence but had no effect on the cell-surface expression of beta2-integrins, respiratory burst in response to phorbol ester, or non-beta2-integrin-dependent adherence to plastic plates coated with a fibronectin-like protein. beta2-Integrin adherence was restored by incubating blood with 8-bromoguanosine 3',5'-cyclic monophosphate (cGMP) and hyperbaric O(2) inhibited synthesis of cGMP by neutrophils stimulated with N-formyl-Met-Leu-Phe (FMLP). In studies of cell fractions, the activity of membrane guanylate cyclase was found to be increased by incubation with FMLP as well as by atrial natriuretic peptide (ANP) plus ATP. Hyperbaric O(2) had no effect on the basal activity of soluble or membrane-bound guanylate cyclase. However, hyperbaric O(2) inhibited the function of both the extracellular binding domain of membrane guanylate cyclase as well as intracellular catalytic activity. There are approximately 7,300 membrane guanylate cyclase molecules per cell, based on binding studies with ANP, with a dissociation constant of approximately 450 pM. Hyperbaric O(2) inhibits the function of human neutrophil beta2-integrins by a process linked to impaired synthesis of cGMP. a

Membrane guanylate cyclase is a cell-surface receptor with homology to protein kinases

Nature ◽  
1988 ◽  
Vol 334 (6184) ◽  
pp. 708-712 ◽  
Author(s):  
Sujay Singh ◽  
David G. Lowe ◽  
David S. Thorpe ◽  
Henry Rodriguez ◽  
Wun-Jing Kuang ◽  
...  
Keyword(s):  
Cell Surface ◽  
Protein Kinases ◽  
Guanylate Cyclase ◽  
Cell Surface Receptor ◽  
Membrane Guanylate Cyclase ◽  
Surface Receptor ◽  
A Cell

A novel calcium-dependent activator of retinal rod outer segment membrane guanylate cyclase

Biochemistry ◽  
1995 ◽  
Vol 34 (44) ◽  
pp. 14279-14283 ◽  
Author(s):  
Nikolay Pozdnyakov ◽  
Akiko Yoshida ◽  
Nigel G. F. Cooper ◽  
Alexander Margulis ◽  
Teresa Duda ◽  
...  
Keyword(s):  
Guanylate Cyclase ◽  
Outer Segment ◽  
Membrane Guanylate Cyclase ◽  
Rod Outer Segment ◽  
Calcium Dependent ◽  
Retinal Rod
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