Potential Roles of Accelerated Dopamine Oxidation, Altered Glutathione Metabolism, 5-S-Cysteinyl-Dopamine and its Oxidative Metabolites in the Pathogenesis of Parkinson’s Disease

2000 ◽  
pp. 181-209 ◽  
Author(s):  
Glenn Dryhurst ◽  
Xue-Ming Shen ◽  
Hong Li ◽  
Zhaoliang Yang ◽  
Jilin Han ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Glutathione Metabolism ◽  
Dopamine Oxidation ◽  
Oxidative Metabolites

scholarly journals Dopamine oxidation mediates mitochondrial and lysosomal dysfunction in Parkinson’s disease

Science ◽  
2017 ◽  
Vol 357 (6357) ◽  
pp. 1255-1261 ◽  
Author(s):  
Lena F. Burbulla ◽  
Pingping Song ◽  
Joseph R. Mazzulli ◽  
Enrico Zampese ◽  
Yvette C. Wong ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Dopamine Oxidation ◽  
Lysosomal Dysfunction

Dopamine Oxidation Products as Mitochondrial Endotoxins, a Potential Molecular Mechanism for Preferential Neurodegeneration in Parkinson’s Disease

2018 ◽  
Vol 9 (11) ◽  
pp. 2849-2858 ◽  
Author(s):  
Alice Biosa ◽  
Irene Arduini ◽  
Maria Eugenia Soriano ◽  
Valentina Giorgio ◽  
Paolo Bernardi ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Molecular Mechanism ◽  
Oxidation Products ◽  
Dopamine Oxidation

Integrating glutathione metabolism and mitochondrial dysfunction with implications for Parkinson’s disease: A dynamic model

Neuroscience ◽  
2007 ◽  
Vol 149 (4) ◽  
pp. 917-930 ◽  
Author(s):  
S. Vali ◽  
R.B. Mythri ◽  
B. Jagatha ◽  
J. Padiadpu ◽  
K.S. Ramanujan ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Mitochondrial Dysfunction ◽  
Dynamic Model ◽  
Glutathione Metabolism

scholarly journals Inhibition of the Fe(III)-Catalyzed Dopamine Oxidation by ATP and Its Relevance to Oxidative Stress in Parkinson’s Disease

2013 ◽  
Vol 4 (9) ◽  
pp. 1305-1313 ◽  
Author(s):  
Dianlu Jiang ◽  
Shuyun Shi ◽  
Lin Zhang ◽  
Lin Liu ◽  
Bingrong Ding ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Dopamine Oxidation

scholarly journals Dopamine Oxidation and Autophagy

2012 ◽  
Vol 2012 ◽  
pp. 1-13 ◽  
Author(s):  
Patricia Muñoz ◽  
Sandro Huenchuguala ◽  
Irmgard Paris ◽  
Juan Segura-Aguilar
Keyword(s):  
Oxidative Stress ◽  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Mitochondrial Dysfunction ◽  
Protein Degradation ◽  
Dopaminergic Neurons ◽  
Molecular Mechanisms ◽  
Neurodegenerative Process ◽  
Dopamine Oxidation

The molecular mechanisms involved in the neurodegenerative process of Parkinson's disease remain unclear. Currently, there is a general agreement that mitochondrial dysfunction,α-synuclein aggregation, oxidative stress, neuroinflammation, and impaired protein degradation are involved in the neurodegeneration of dopaminergic neurons containing neuromelanin in Parkinson's disease. Aminochrome has been proposed to play an essential role in the degeneration of dopaminergic neurons containing neuromelanin by inducing mitochondrial dysfunction, oxidative stress, the formation of neurotoxicα-synuclein protofibrils, and impaired protein degradation. Here, we discuss the relationship between the oxidation of dopamine to aminochrome, the precursor of neuromelanin, autophagy dysfunction in dopaminergic neurons containing neuromelanin, and the role of dopamine oxidation to aminochrome in autophagy dysfunction in dopaminergic neurons. Aminochrome induces the following: (i) the formation ofα-synuclein protofibrils that inactivate chaperone-mediated autophagy; (ii) the formation of adducts withα- andβ-tubulin, which induce the aggregation of the microtubules required for the fusion of autophagy vacuoles and lysosomes.

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