Dopamine Oxidation Products as Mitochondrial Endotoxins, a Potential Molecular Mechanism for Preferential Neurodegeneration in Parkinson’s Disease

2018 ◽  
Vol 9 (11) ◽  
pp. 2849-2858 ◽  
Author(s):  
Alice Biosa ◽  
Irene Arduini ◽  
Maria Eugenia Soriano ◽  
Valentina Giorgio ◽  
Paolo Bernardi ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Molecular Mechanism ◽  
Oxidation Products ◽  
Dopamine Oxidation

scholarly journals Dopamine oxidation mediates mitochondrial and lysosomal dysfunction in Parkinson’s disease

Science ◽  
2017 ◽  
Vol 357 (6357) ◽  
pp. 1255-1261 ◽  
Author(s):  
Lena F. Burbulla ◽  
Pingping Song ◽  
Joseph R. Mazzulli ◽  
Enrico Zampese ◽  
Yvette C. Wong ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Dopamine Oxidation ◽  
Lysosomal Dysfunction

scholarly journals HIGH-MOBILITY GROUP BOX 1 (HMGB1) PROTEIN EVALUATION IN MPTP-INDUCED ZEBRAFISH MODEL OF PARKINSON’S DISEASE

2021 ◽  
Author(s):  
Wael MY Mohamed ◽  
Khairiah Razali ◽  
Noratikah Othman ◽  
Mohamed Hamza ◽  
Abdel Moneem Doolane ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Molecular Mechanism ◽  
High Mobility ◽  
High Mobility Group ◽  
Current Evidence ◽  
Hmgb1 Protein ◽  
Zebrafish Model ◽  
Molecular Studies

Molecular studies have proven beneficial in understanding the pathophysiology of PD. Besides, the advancing application of zebrafish as a PD model has enabled researchers to conduct molecular studies with more promising outcomes and significance. Current evidence reported on the association of HMGB1 protein with neuroinflammation-induced PD pathogenesis. However, to the extent ofour knowledge, the molecular mechanism pertaining to HMGB1 involvement in PD are still elusive. Hence, we propose to conduct a study on HMGB1 protein, to elucidate its role in the pathogenesis of the MPTP-induced zebrafish model of PD. This study will answer the question pertaining to the involvement of HMGB1 in PD development and whether the knockdown of this protein can improve PD symptoms in zebrafish, particularly MPTP-induced motilitydisorders.

Sign in / Sign up

Export Citation Format

Share Document