Lung Repair, Remodeling, and Fibrosis

2001 ◽  
pp. 213-227
Author(s):  
Sujata Guharoy ◽  
Sem H. Phan
Keyword(s):  
Lung Repair

scholarly journals Hypercapnia limits β-catenin mediated alveolar type 2 cell progenitor function by altering Wnt production from adjacent fibroblasts

2022 ◽  
Author(s):  
Laura A Dada ◽  
Lynn C Welch ◽  
Natalia D Magnani ◽  
Ziyou Ren ◽  
Patricia L Brazee ◽  
...  
Keyword(s):  
Alveolar Type ◽  
Mechanically Ventilated ◽  
Persistent Symptoms ◽  
Low Tidal Volume ◽  
Lung Repair ◽  
Ventilator Induced Lung Injury ◽  
Lung Flooding ◽  
Volume Ventilation

Persistent symptoms and radiographic abnormalities suggestive of failed lung repair are among the most common symptoms in patients with COVID-19 after hospital discharge. In mechanically ventilated patients with ARDS secondary to SARS-CoV-2 pneumonia, low tidal volume ventilation to reduce ventilator-induced lung injury necessarily elevate blood CO2 levels, often leading to hypercapnia. The role of hypercapnia on lung repair after injury is not completely understood. Here, we show that hypercapnia limits β-catenin signaling in alveolar type 2 (AT2) cells, leading to reduced proliferative capacity. Hypercapnia alters expression of major Wnts in PDGFRα-fibroblasts from those maintaining AT2 progenitor activity and towards those that antagonize β-catenin signaling and limit progenitor function. Activation of β-catenin signaling in AT2 cells, rescues the effects of hypercapnia on proliferation. Inhibition of AT2 proliferation in hypercapnic patients may contribute to impaired lung repair after injury, preventing sealing of the epithelial barrier, increasing lung flooding, ventilator dependency and mortality.

Monocyte-derived Alveolar Macrophages: The Dark Side of Lung Repair?

2018 ◽  
Vol 58 (1) ◽  
pp. 5-6 ◽  
Author(s):  
Alexandra C. McQuattie-Pimentel ◽  
G. R. Scott Budinger ◽  
Megan N. Ballinger
Keyword(s):  
Alveolar Macrophages ◽  
Dark Side ◽  
Lung Repair

Interferons interfere with lung repair

Science ◽  
2020 ◽  
Vol 369 (6504) ◽  
pp. 639.18-641
Author(s):  
Seth Thomas Scanlon
Keyword(s):  
Lung Repair

scholarly journals The acid injury and repair (AIR) model: A novel ex-vivo tool to understand lung repair

Biomaterials ◽  
2021 ◽  
Vol 267 ◽  
pp. 120480 ◽  
Author(s):  
Sally Yunsun Kim ◽  
Róisín Mongey ◽  
Peizhu Wang ◽  
Stephen Rothery ◽  
David C.A. Gaboriau ◽  
...  
Keyword(s):  
Ex Vivo ◽  
Lung Repair ◽  
Injury And Repair

Epithelial–Mesenchymal Interactions During Lung Development and Their Potential Relevance to Lung Repair

2010 ◽  
pp. 91-124 ◽  
Author(s):  
Alexandra Firsova ◽  
Tomoko Hyakumura ◽  
Timothy J. Cole ◽  
Richard Mollard
Keyword(s):  
Lung Development ◽  
Lung Repair

Lung cancer mirrors lung repair

2003 ◽  
Vol 4 (4) ◽  
pp. 199
Author(s):  
Anna York
Keyword(s):  
Lung Cancer ◽  
Lung Repair

scholarly journals Hepatocyte growth factor in lung repair and pulmonary fibrosis

2010 ◽  
Vol 32 (1) ◽  
pp. 12-20 ◽  
Author(s):  
Ronald Allan M Panganiban ◽  
Regina M Day
Keyword(s):  
Growth Factor ◽  
Pulmonary Fibrosis ◽  
Hepatocyte Growth Factor ◽  
Lung Repair ◽  
Hepatocyte Growth

Sex Differences In Lung Repair Following Sidestream Smoke Exposure

2011 ◽  
Author(s):  
Laura Van Winkle ◽  
Katherine Sutherland ◽  
Jackie Chan ◽  
Rose de Guzman ◽  
Judith Shimizu ◽  
...  
Keyword(s):  
Sex Differences ◽  
Smoke Exposure ◽  
Lung Repair ◽  
Sidestream Smoke

Human Placentally-Derived Stem Cells Abrogate Fibrosis And Augment Lung Repair But Differ In Plasticity

2010 ◽  
Author(s):  
Yuben Moodley ◽  
Sivagami Ilancheran ◽  
Chrishan Samuel ◽  
Graham Jenkin ◽  
Euan Wallace ◽  
...  
Keyword(s):  
Stem Cells ◽  
Lung Repair

scholarly journals Potential therapeutic targets for lung repair during human ex vivo lung perfusion

2020 ◽  
Vol 55 (4) ◽  
pp. 1902222 ◽  
Author(s):  
Aaron Wong ◽  
Ricardo Zamel ◽  
Jonathan Yeung ◽  
Gary D. Bader ◽  
Claudia C. Dos Santos ◽  
...  
Keyword(s):  
Cell Death ◽  
Ex Vivo ◽  
Therapeutic Targets ◽  
Lymphocyte Activation ◽  
Lung Perfusion ◽  
Ex Vivo Lung Perfusion ◽  
Lung Repair ◽  
Molecular Features ◽  
Donor Lung ◽  
Donation After Brain Death

IntroductionThe ex vivo lung perfusion (EVLP) technique has been developed to assess the function of marginal donor lungs and has significantly increased donor lung utilisation. EVLP has also been explored as a platform for donor lung repair through injury-specific treatments such as antibiotics or fibrinolytics. We hypothesised that actively expressed pathways shared between transplantation and EVLP may reveal common mechanisms of injury and potential therapeutic targets for lung repair prior to transplantation.Materials and methodsRetrospective transcriptomics analyses were performed with peripheral tissue biopsies from “donation after brain death” lungs, with 46 pre-/post-transplant pairs and 49 pre-/post-EVLP pairs. Pathway analysis was used to identify and compare the responses of donor lungs to transplantation and to EVLP.Results22 pathways were enriched predominantly in transplantation, including upregulation of lymphocyte activation and cell death and downregulation of metabolism. Eight pathways were enriched predominantly in EVLP, including downregulation of leukocyte functions and upregulation of vascular processes. 27 pathways were commonly enriched, including activation of innate inflammation, cell death, heat stress and downregulation of metabolism and protein synthesis. Of the inflammatory clusters, Toll-like receptor/innate immune signal transduction adaptor signalling had the greatest number of nodes and was central to inflammation. These mechanisms have been previously speculated as major mechanisms of acute lung injury in animal models.ConclusionEVLP and transplantation share common molecular features of injury including innate inflammation and cell death. Blocking these pathways during EVLP may allow for lung repair prior to transplantation.

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