Regulation of Lung Immunity: Significance of the Cytokine Environment

2001 ◽  
pp. 53-69
Author(s):  
Nicholas W. Lukacs ◽  
Theodore Standiford ◽  
Cory Hogaboam ◽  
Steven L. Kunkel
Keyword(s):  
Lung Immunity

62 Lung immunity to a soluble antigen

1988 ◽  
Vol 81 (1) ◽  
pp. 184
Author(s):  
David N. Weissman ◽  
David E. Bice ◽  
Bruce A. Muggenburg ◽  
Mark R. Schuyler
Keyword(s):  
Soluble Antigen ◽  
Lung Immunity

Effect of lung damage by acute exposure to nitrogen dioxide on lung immunity in the rat

1980 ◽  
Vol 23 (2) ◽  
pp. 362-370 ◽  
Author(s):  
C.T. Schnizlein ◽  
D.E. Bice ◽  
A.H. Rebar ◽  
R.K. Wolff ◽  
R.L. Beethe
Keyword(s):  
Nitrogen Dioxide ◽  
Lung Damage ◽  
Acute Exposure ◽  
Lung Immunity

PPAR‐γ in innate and adaptive lung immunity

2018 ◽  
Vol 104 (4) ◽  
pp. 737-741 ◽  
Author(s):  
Samuel Philip Nobs ◽  
Manfred Kopf
Keyword(s):  
Ppar Γ ◽  
Lung Immunity

Siglec-F Determines Lung Immunity Through Regulation of Macrophage Gap Junctions

2019 ◽  
Author(s):  
L. Li ◽  
G.A. Gusarova ◽  
M.N. Islam ◽  
J. Bhattacharya
Keyword(s):  
Gap Junctions ◽  
Lung Immunity

scholarly journals Human Adipose‐Derived Mesenchymal Stem Cells Modify Lung Immunity and Improve Antibacterial Defense in Pneumosepsis Caused by Klebsiella pneumoniae

2019 ◽  
Vol 8 (8) ◽  
pp. 785-796 ◽  
Author(s):  
Desiree Perlee ◽  
Alex F. Vos ◽  
Brendon P. Scicluna ◽  
Pablo Mancheño ◽  
Olga Rosa ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Klebsiella Pneumoniae ◽  
Lung Immunity

IL-1β-independent activation of lung immunity in male mice by female odor

2013 ◽  
Vol 30 ◽  
pp. 150-155 ◽  
Author(s):  
Mikhail P. Moshkin ◽  
Galina V. Kontsevaya ◽  
Ekaterina A. Litvinova ◽  
Ludmila A. Gerlinskaya
Keyword(s):  
Male Mice ◽  
Female Odor ◽  
Lung Immunity

scholarly journals Integrative Analysis of Spatial Transcriptome with Single-cell Transcriptome and Single-cell Epigenome in Mouse Lungs after Immunization

2021 ◽  
Author(s):  
Zhongli Xu ◽  
Xinjun Wang ◽  
Li Fan ◽  
Fujing Wang ◽  
Jiebiao Wang ◽  
...  
Keyword(s):  
Single Cell ◽  
T Helper Cells ◽  
Integrative Analysis ◽  
Cytokine Signaling ◽  
Specific Cell ◽  
Cell Type ◽  
T Helper ◽  
Communication Analysis ◽  
Helper Cells ◽  
Lung Immunity

Immunological memory is key to productive adaptive immunity. An unbiased, high through-put gene expression profiling of tissue-resident memory T cells residing in various anatomical location within the lung is fundamental to understand lung immunity but still lacking. In this study, using a well-established model on Klebsiella pneumoniae, we performed an integrative analysis of spatial transcriptome with single-cell RNA-seq and single-cell ATAC-seq on lung cells from mice after Immunization using the 10x Genomics Chromium and Visium platform. We employed several deconvolution algorithms and established an optimized deconvolution pipeline to accurately decipher specific cell-type composition by location. We identified and located 12 major cell types by scRNA-seq and spatial transcriptomic analysis. Integrating scATAC-seq data from the same cells processed in parallel with scRNA-seq, we found epigenomic profiles provide more robust cell type identification, especially for lineage-specific T helper cells. When combining all three data modalities, we observed a dynamic change in the location of T helper cells as well as their corresponding chemokines for chemotaxis. Furthermore, cell-cell communication analysis of spatial transcriptome provided evidence of lineage-specific T helper cells receiving designated cytokine signaling. In summary, our first-in-class study demonstrated the power of multi-omics analysis to uncover intrinsic spatial- and cell-type-dependent molecular mechanisms of lung immunity. Our data provides a rich research resource of single cell multi-omics data as a reference for understanding spatial dynamics of lung immunization.

scholarly journals Spatiotemporal Cellular Networks Maintain Immune Homeostasis in the Lung

2020 ◽  
Author(s):  
Jessica Borger
Keyword(s):  
Immune Cells ◽  
Immune Cell ◽  
Respiratory Epithelium ◽  
Physical Barrier ◽  
Pulmonary Tissue ◽  
Danger Signals ◽  
Cell Network ◽  
Defence Proteins ◽  
Molecular Signals ◽  
Lung Immunity

A dynamic and intricately connected tissue-resident immune cell network continuously monitors the lungs, which are incessantly subjected to external environmental insults. The lungs are protected by the respiratory epithelium, which not only serves as a physical barrier through mucociliary mechanisms, but also a reactive one that can release cytokines, chemokines, and other defence proteins in response to danger signals. In the maintenance of pulmonary homeostasis in health, the lung-resident immune cell network instructs tolerance to innocuous particulates and can rapidly and efficiently drive immunity and memory to pathogenic antigens. This review examines the spatiotemporal dynamics that underlie the exquisite network of highly specialised immune cells and their mediators in the support of pulmonary tissue homeostasis and effective lung immunity in health. In particular, this review examines the specialised immune cells that reside in distinct populations within the diverse compartments of the lung, and the molecular signals that retain and recruit lung-resident immune cells, to further our understanding of how these can be targeted therapeutically to return inflamed or diseased lungs to homeostasis.

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