The Antitumour Activity of ZD9331, a Non-Polyglutamatable Quinazoline Thymidylate Synthase Inhibitor

Purine and Pyrimidine Metabolism in Man VIII - Advances in Experimental Medicine and Biology ◽

10.1007/978-1-4615-2584-4_40 ◽

1995 ◽

pp. 185-188 ◽

Author(s):

Ann L. Jackman ◽

Rosemary Kimbell ◽

Melody Brown ◽

Lisa Brunton ◽

Kenneth R. Harrap ◽

...

Keyword(s):

Thymidylate Synthase ◽

Antitumour Activity ◽

Thymidylate Synthase Inhibitor ◽

Synthase Inhibitor

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‘Tomudex’ (ZD1694) : A novel thymidylate synthase inhibitor with clinical antitumour activity in a range of solid tumours

Annals of Oncology ◽

10.1093/oxfordjournals.annonc.a010546 ◽

1996 ◽

Vol 7 (2) ◽

pp. 179-182 ◽

Author(s):

D. Cunningham ◽

J. Zalcberg ◽

I. Smith ◽

M. Gore ◽

R. Pazdur ◽

...

Keyword(s):

Thymidylate Synthase ◽

Antitumour Activity ◽

Solid Tumours ◽

Thymidylate Synthase Inhibitor ◽

Synthase Inhibitor

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Phase I, Pharmacokinetic and Biological Correlative Study of OSI-7904L, a Novel Liposomal Thymidylate Synthase Inhibitor, and Cisplatin in Patients with Solid Tumors

Clinical Cancer Research ◽

10.1158/1078-0432.ccr-08-0864 ◽

2008 ◽

Vol 14 (23) ◽

pp. 7947-7955 ◽

Author(s):

Alejandro D. Ricart ◽

Jordan D. Berlin ◽

Kyriakos P. Papadopoulos ◽

Samira Syed ◽

Daniel W. Drolet ◽

...

Keyword(s):

Phase I ◽

Solid Tumors ◽

Thymidylate Synthase ◽

Correlative Study ◽

Thymidylate Synthase Inhibitor ◽

Synthase Inhibitor

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Polyglutamation of the Thymidylate Synthase Inhibitor, N10-Propargyl-5,8-Dideazafolic Acid (CB 3717), in Organs of Ehrlich Ascites Carcinoma-Bearing Mice

Montreal, Canada, June 15–20, 1986 ◽

10.1515/9783110856262-190 ◽

1986 ◽

pp. 993-996

Keyword(s):

Thymidylate Synthase ◽

Ehrlich Ascites Carcinoma ◽

Ehrlich Ascites ◽

Thymidylate Synthase Inhibitor ◽

Synthase Inhibitor

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A phase I study of the lipophilic thymidylate synthase inhibitor Thymitaq™ (nolatrexed dihydrochloride) given by 10-day oral administration

British Journal of Cancer ◽

10.1038/sj.bjc.6690146 ◽

1999 ◽

Vol 79 (5-6) ◽

pp. 915-920 ◽

Author(s):

D I Jodrell ◽

A Bowman ◽

R Rye ◽

B Byrne ◽

A Boddy ◽

...

Keyword(s):

Oral Administration ◽

Phase I ◽

Thymidylate Synthase ◽

Phase I Study ◽

Thymidylate Synthase Inhibitor ◽

Synthase Inhibitor

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New Synthesis of Thymidylate Synthase Inhibitor Raltitrexed

Synthetic Communications ◽

10.1081/scc-120024732 ◽

2003 ◽

Vol 33 (20) ◽

pp. 3519-3526 ◽

Author(s):

Sheng-Li Cao ◽

Rong Wan ◽

Yu-Ping Feng

Keyword(s):

Thymidylate Synthase ◽

New Synthesis ◽

Thymidylate Synthase Inhibitor ◽

Synthase Inhibitor

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Synergy between the non-classical thymidylate synthase inhibitor AG337 (ThymitaqR) and cisplatin in human colon and ovarian cancer cells

Anti-Cancer Drugs ◽

10.1097/00001813-199609000-00006 ◽

1996 ◽

Vol 7 (7) ◽

pp. 752-757 ◽

Author(s):

Eric Raymond ◽

Siham Djelloul ◽

Christine Buquet-Fagot ◽

Jan Mester ◽

Christian Gespach

Keyword(s):

Ovarian Cancer ◽

Cancer Cells ◽

Thymidylate Synthase ◽

Human Colon ◽

Ovarian Cancer Cells ◽

Thymidylate Synthase Inhibitor ◽

Synthase Inhibitor

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ChemInform Abstract: Syntheses of a Regioisomer of N-(4-(2-(2-Amino-4(3H)-oxo-7H-pyrrolo(2, 3-d)pyrimidin-5-yl)ethyl)benzoyl)-L -glutamic Acid (LY231514), an Active Thymidylate Synthase Inhibitor and Antitumor Agent.

10.1002/chin.199403177 ◽

2010 ◽

Vol 25 (3) ◽

pp. no-no

Author(s):

E. C. TAYLOR ◽

W. B. YOUNG ◽

R. CHAUDHARI ◽

H. H. PATEL

Keyword(s):

Glutamic Acid ◽

Thymidylate Synthase ◽

Antitumor Agent ◽

Thymidylate Synthase Inhibitor ◽

Synthase Inhibitor

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Characterization of the effect of AG337, a novel lipophilic thymidylate synthase inhibitor, on human head and neck and human leukemia cell lines.

International Journal of Oncology ◽

10.3892/ijo.15.6.1245 ◽

1999 ◽

Author(s):

J J McGuire ◽

J G Canestrari ◽

G S Nagel

Keyword(s):

Head And Neck ◽

Thymidylate Synthase ◽

Leukemia Cell ◽

Human Leukemia ◽

Leukemia Cell Lines ◽

Thymidylate Synthase Inhibitor ◽

Synthase Inhibitor

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BGC 945, a Novel Tumor-Selective Thymidylate Synthase Inhibitor Targeted to α-Folate Receptor–Overexpressing Tumors

Cancer Research ◽

10.1158/0008-5472.can-05-2034 ◽

2005 ◽

Vol 65 (24) ◽

pp. 11721-11728 ◽

Author(s):

David D. Gibbs ◽

Davinder S. Theti ◽

Nadya Wood ◽

Matthew Green ◽

Florence Raynaud ◽

...

Keyword(s):

Thymidylate Synthase ◽

Folate Receptor ◽

Thymidylate Synthase Inhibitor ◽

Synthase Inhibitor ◽

Tumor Selective

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Destruction of WiDr multicellular tumor spheroids?with the novel thymidylate synthase inhibitor 1843U89?at physiological thymidine concentrations

Cancer Chemotherapy and Pharmacology ◽

10.1007/s002800050082 ◽

1994 ◽

Vol 33 (6) ◽

pp. 455-459

Author(s):

Sheila D. Banks ◽

Kathleen A. Waters ◽

Linda L. Barrett ◽

Scott Dickerson ◽

William Pendergast ◽

...

Keyword(s):

Thymidylate Synthase ◽

The Novel ◽

Multicellular Tumor Spheroids ◽

Tumor Spheroids ◽

Thymidylate Synthase Inhibitor ◽

Synthase Inhibitor

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