Marine Invertebrates and Microbes as Sources of Potential Antitumor Compounds

1994 ◽  
pp. 39-61
Author(s):  
Andrew L. Staley ◽  
Jon Clardy
Keyword(s):  
Marine Invertebrates ◽  
Antitumor Compounds ◽  
Potential Antitumor

Application of a Validated QSTR Model for Repurposing COX-2 Inhibitor Coumarin Derivatives as Potential Antitumor Agents

2019 ◽  
Vol 19 (13) ◽  
pp. 1121-1128 ◽  
Author(s):  
Gulcin Tugcu ◽  
Hande Sipahi ◽  
Ahmet Aydin
Keyword(s):  
Antitumor Activity ◽  
Drug Development ◽  
Linear Model ◽  
Cell Lines ◽  
Cyclooxygenase 2 ◽  
Large Set ◽  
Coumarin Derivatives ◽  
Antitumor Compounds ◽  
Cyclooxygenase 2 Inhibitors ◽  
Potential Antitumor

Background: The discovery of novel potent molecules for both cancer prevention and treatment has been continuing over the past decade. In recent years, identification of new, potent, and safe anticancer agents through drug repurposing has been regarded as an expeditious alternative to traditional drug development. The cyclooxygenase-2 is known to be over-expressed in several types of human cancer. For this reason cyclooxygenase-2 inhibition may be useful tool for cancer chemotherapy. Objective: The first aim of the study was to develop a validated linear model to predict antitumor activity. Subsequently, applicability of the model for repurposing these cyclooxygenase-2 inhibitors as antitumor compounds to abridge drug development process. Method: We performed a quantitative structure-toxicity relationship (QSTR) study on a set of coumarin derivatives using a large set of molecular descriptors. A linear model predicting growth inhibition on leukemia CCRF cell lines was developed and consequently validated internally and externally. Accordingly, the model was applied on a set of 143 cyclooxygenase-2 inhibitor coumarin derivatives to explore their antitumor activity. Results: The results indicated that the developed QSAR model would be useful for estimating inhibitory activity of coumarin derivatives on leukemia cell lines. Electronegativity was found to be a prominent property of the molecules in describing antitumor activity. The applicability domain of the developed model highlighted the potential antitumor compounds. Conclusion: The promising results revealed that applied integrated in silico approach for repurposing by combining both the biological activity similarity and the molecular similarity via the computational method could be efficiently used to screen potential antitumor compounds among cyclooxygenase-2 inhibitors.

Cytotoxic and Antitumor Compounds from Marine Invertebrates

2020 ◽  
pp. 2529-2584
Author(s):  
Harika Atmaca Ilhan ◽  
Çisil Çamlı Pulat
Keyword(s):  
Marine Invertebrates ◽  
Antitumor Compounds

New potential antitumor compounds from the plant Aristolochia manshuriensis as inhibitors of the CDK2 enzyme

2010 ◽  
Vol 20 (4) ◽  
pp. 1344-1346 ◽  
Author(s):  
Vinod R. Hegde ◽  
Scott Borges ◽  
Mahesh Patel ◽  
Pradip R. Das ◽  
Bonnie Wu ◽  
...  
Keyword(s):  
Antitumor Compounds ◽  
Aristolochia Manshuriensis ◽  
Potential Antitumor

scholarly journals Fluorinated analogues of lipidic dialkynylcarbinol pharmacophores: synthesis and cytotoxicity in HCT116 cancer cells

2019 ◽  
Vol 7 (1) ◽  
pp. 1-9
Author(s):  
Pauline Rullièrea ◽  
François Lizeauxa ◽  
Etienne Jolyb ◽  
Stéphanie Ballereaua ◽  
Hafida Gasparda ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Mode Of Action ◽  
Biological Evaluation ◽  
Specific Study ◽  
Antitumor Compounds ◽  
Fluorinated Derivatives ◽  
Hct116 Cells ◽  
Potential Antitumor

Lipidic alkynylcarbinols (LACs) have been identified as potential antitumor compounds, and a thorough understanding of their pharmacophoric environment is now required to elucidate their biological mode of action. In the dialkynylcarbinol (DAC) series, a specific study of the pharmacophore potential has been undertaken by focusing on the synthesis of three fluorinated derivatives followed by their biological evaluation. This work highlights the requirement of an electron-rich secondary carbinol center as a key structure for cytotoxicity in HCT116 cells.

ChemInform Abstract: New Potential Antitumor Compounds from the Plant Aristolochia manshuriensis as Inhibitors of the CDK2 Enzyme.

ChemInform ◽  
2010 ◽  
Vol 41 (26) ◽  
pp. no-no
Author(s):  
Vinod R. Hegde ◽  
Scott Borges ◽  
Mahesh Patel ◽  
Pradip R. Das ◽  
Bonnie Wu ◽  
...  
Keyword(s):  
Antitumor Compounds ◽  
Aristolochia Manshuriensis ◽  
Potential Antitumor

ChemInform Abstract: SEARCH FOR POTENTIAL ANTITUMOR COMPOUNDS PART 9

1974 ◽  
Vol 5 (22) ◽  
pp. no-no
Author(s):  
A. B. SEN ◽  
R. N. KAPOOR
Keyword(s):  
Antitumor Compounds ◽  
Potential Antitumor

Synthesis and Evaluation of Novel Erucin Analogues as Potential Antitumor Compounds

2018 ◽  
Vol 15 (3) ◽  
Author(s):  
Yan-Dong Shao ◽  
Huang-Wang Song ◽  
Wen Feng ◽  
Xiang-Hui Wang ◽  
Zai-Feng Shi ◽  
...  
Keyword(s):  
Antitumor Compounds ◽  
Potential Antitumor
Sign in / Sign up

Export Citation Format

Share Document