Interleukin-8 Down-Regulates the Oxidative Burst Induced by Tumor Necrosis Factor Alpha in Neutrophils Adherent to Fibronectin

1993 ◽  
pp. 221-221
Author(s):  
L. Ottonello ◽  
I. J. D. Lindley ◽  
G. Pastorino ◽  
P. Dapino ◽  
F. Dallegri
Keyword(s):  
Tumor Necrosis Factor ◽  
Tumor Necrosis Factor Alpha ◽  
Oxidative Burst ◽  
Tumor Necrosis ◽  
Interleukin 8 ◽  
Necrosis Factor Alpha ◽  
Factor Alpha ◽  
Necrosis Factor

Paget’s disease of bone is not associated with common polymorphisms in interleukin-6, interleukin-8 and tumor necrosis factor alpha genes

Cytokine ◽  
2010 ◽  
Vol 52 (3) ◽  
pp. 146-150 ◽  
Author(s):  
Luis Corral-Gudino ◽  
Javier del Pino-Montes ◽  
Judit García-Aparicio ◽  
Manuel Alonso-Garrido ◽  
Rogelio González-Sarmiento
Keyword(s):  
Tumor Necrosis Factor ◽  
Tumor Necrosis Factor Alpha ◽  
Interleukin 6 ◽  
Tumor Necrosis ◽  
Paget’S Disease ◽  
Interleukin 8 ◽  
Paget's Disease Of Bone ◽  
Necrosis Factor Alpha ◽  
Factor Alpha ◽  
Necrosis Factor

Cytokines in adenoviral disease in children: Association of interleukin-6, interleukin-8, and tumor necrosis factor alpha levels with clinical outcome

1994 ◽  
Vol 124 (5) ◽  
pp. 714-720 ◽  
Author(s):  
Alicia S. Mistchenko ◽  
Roberto A. Diez ◽  
Ana La Mariani ◽  
Julio Robaldo ◽  
Alberto F. Maffey ◽  
...  
Keyword(s):  
Tumor Necrosis Factor ◽  
Clinical Outcome ◽  
Tumor Necrosis Factor Alpha ◽  
Interleukin 6 ◽  
Tumor Necrosis ◽  
Interleukin 8 ◽  
Necrosis Factor Alpha ◽  
Factor Alpha ◽  
Necrosis Factor

scholarly journals Hemoglobin stimulates mononuclear leukocytes to release interleukin-8 and tumor necrosis factor alpha

Blood ◽  
1994 ◽  
Vol 84 (9) ◽  
pp. 3175-3181
Author(s):  
SJ McFaul ◽  
PD Bowman ◽  
VM Villa ◽  
MJ Gutierrez-Ibanez ◽  
M Johnson ◽  
...  
Keyword(s):  
Tumor Necrosis Factor ◽  
Tumor Necrosis Factor Alpha ◽  
Tumor Necrosis ◽  
Chemotactic Activity ◽  
Interleukin 8 ◽  
Tnf Alpha ◽  
Mononuclear Leukocytes ◽  
Necrosis Factor Alpha ◽  
Factor Alpha ◽  
Necrosis Factor

Incubation of human mononuclear leukocytes (MNL) with human stroma-free hemolysate (SFH), purified adult hemoglobin Ao (HbAo), and oxidized HbAo (METHb) caused MNL to release compounds into the supernate that mediated neutrophil (polymorphonuclear leukocytes, PMN) chemotaxis and PMN adherence to human umbilical vein endothelial cells (HUVEC). Chemotaxis and PMN adherence to HUVEC were reduced significantly when supernates were preincubated with neutralizing antibodies to interleukin-8 (IL-8) and tumor necrosis factor alpha (TNF-alpha), respectively, suggesting that IL-8 and TNF-alpha played significant roles in mediating these activities. Greatest chemotactic activity was observed in supernates of MNL treated with HbAo; while greatest PMN/endothelial cell (EC) adherence activity was observed in supernates of MNL treated with METHb. Furthermore, PMN/EC adherence activity was a function of METHb content in each hemoglobin solution. PMN chemotaxis, PMN adherence to HUVEC, and cytokine release increased as a function of increasing incubation time. Chemotactic activity was detected in HbAo- treated and METHb-treated MNL supernates after incubation for 6 hours and was maximal by 10 hours. IL-8 was detected in both HbAo and METHb- MNL supernates by 4 hours. PMN/EC adherence activity was detected in HbAo-MNL supernates at 10 hours and in METHb-MNL supernates at 4 hours. TNF-alpha was detected in METHb and HbAo-MNL supernates at 4 and 12 hours, respectively. These results suggest that hemoglobin solutions stimulate MNL to release IL-8 and TNF-alpha in quantities sufficient to induce PMN chemotaxis and PMN adherence to HUVEC. This is a US government work. There are no restrictions on its use.

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