scholarly journals Phenotypic and Functional Characterization of CD4+ T-Cells Infiltrating the Central Nervous System of Rats Infected with Coronavirus MHV IV

1994 ◽  
pp. 437-442
Author(s):  
H. Imrich ◽  
S. Schwender ◽  
A. Hein ◽  
R. Dörries
Keyword(s):  
Central Nervous System ◽  
T Cells ◽  
Nervous System ◽  
Cd4 T Cells ◽  
Functional Characterization ◽  
The Central Nervous System

scholarly journals High-Magnitude, Virus-Specific CD4 T-Cell Response in the Central Nervous System of Coronavirus-Infected Mice

2001 ◽  
Vol 75 (6) ◽  
pp. 3043-3047 ◽  
Author(s):  
Jodie S. Haring ◽  
Lecia L. Pewe ◽  
Stanley Perlman
Keyword(s):  
Central Nervous System ◽  
T Cells ◽  
Nervous System ◽  
Cd4 T Cells ◽  
Hepatitis Virus ◽  
T Cell Response ◽  
Acute Encephalitis ◽  
High Magnitude ◽  
The Central Nervous System ◽  
Ifn Γ

ABSTRACT The neurotropic JHM strain of mouse hepatitis virus (MHV) causes acute encephalitis and chronic demyelinating encephalomyelitis in rodents. Previous results indicated that CD8 T cells infiltrating the central nervous system (CNS) were largely antigen specific in both diseases. Herein we show that by 7 days postinoculation, nearly 30% of the CD4 T cells in the acutely infected CNS were MHV specific by using intracellular gamma interferon (IFN-γ) staining assays. In mice with chronic demyelination, 10 to 15% of the CD4 T cells secreted IFN-γ in response to MHV-specific peptides. Thus, these results show that infection of the CNS is characterized by a large influx of CD4 T cells specific for MHV and that these cells remain functional, as measured by cytokine secretion, in mice with chronic demyelination.

scholarly journals Role of CD25+ CD4+ T cells in acute and persistent coronavirus infection of the central nervous system

Virology ◽  
2013 ◽  
Vol 447 (1-2) ◽  
pp. 112-120 ◽  
Author(s):  
Maria Teresa P. de Aquino ◽  
Shweta S. Puntambekar ◽  
Carine Savarin ◽  
Cornelia C. Bergmann ◽  
Timothy W. Phares ◽  
...  
Keyword(s):  
Central Nervous System ◽  
T Cells ◽  
Nervous System ◽  
Cd4 T Cells ◽  
The Central Nervous System ◽  
Coronavirus Infection

Maintenance of CD8+T Cells during Acute Viral Infection of the Central Nervous System Requires CD4+T Cells But Not Interleukin-2

2005 ◽  
Vol 18 (1) ◽  
pp. 162-169 ◽  
Author(s):  
Jiehao Zhou ◽  
David R. Hinton ◽  
Stephen A. Stohlman ◽  
Chih-Pin Liu ◽  
Lingwen Zhong ◽  
...  
Keyword(s):  
Central Nervous System ◽  
T Cells ◽  
Nervous System ◽  
Viral Infection ◽  
Cd8 T Cells ◽  
Cd4 T Cells ◽  
Interleukin 2 ◽  
Acute Viral Infection ◽  
The Central Nervous System

Activated/effector CD4+ T cells exacerbate acute damage in the central nervous system following traumatic injury

2003 ◽  
Vol 136 (1-2) ◽  
pp. 54-66 ◽  
Author(s):  
Dominic Fee ◽  
Amanda Crumbaugh ◽  
Thomas Jacques ◽  
Benjamin Herdrich ◽  
Diane Sewell ◽  
...  
Keyword(s):  
Central Nervous System ◽  
T Cells ◽  
Nervous System ◽  
Cd4 T Cells ◽  
Traumatic Injury ◽  
The Central Nervous System
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