Analytical Methods for Optimizing Knowledge-Based Information Structures in Simulation-Based Training

1993 ◽  
pp. 281-295 ◽  
Author(s):  
Bernhard Zimolong ◽  
Udo Konradt
Keyword(s):  
Analytical Methods ◽  
Information Structures ◽  
Knowledge Based ◽  
Simulation Based

scholarly journals QBD, REVIEW ON COMPREHENSIVE UNDERSTANDING OF BUILDING AN ANALYTICAL QUALITY BY DESIGN FOR DRUG MANUFACTURING PROCESS

2020 ◽  
Vol 9 (2) ◽  
Author(s):  
Shishir Kumar Prasad ◽  
Kalpana Diwekar ◽  
Anita.A
Keyword(s):  
Risk Management ◽  
Analytical Methods ◽  
Quality By Design ◽  
Spectroscopic Method ◽  
Pharmaceutical Product ◽  
Critical Parameters ◽  
Current Status ◽  
Product Concept ◽  
Knowledge Based ◽  
Product And Process

When knowledge based on pure scientific understanding and quality risk management is applied to product and process learning with regulation on process control along with a systematic approach for development of predefined objectives in analytical field then it is called as quality by design or QBD it follow ICH guidelines for quality in pharmaceutical product concept of qbd also extends to analytical methods, it is mandatory process in QBD to define a goal. A protocol for the method which will continue monitoring the process throughout in a systematic way and working on alternate methods as well to get optimal performance, the methods given are carefully analysed in structured pattern for risks and is put for a challenge of the validity of method which later on can be taken for the criteria, benefit of these studies. The performances can be improved as well as clearly understood along with the risk management and desired performance methods  which can also be validated later on, the review briefly gives an inside view of application of analytical QBD in industries and its current status with examples and principles of analytical methods in HPTLC ,titration for moisture content, determination of   toxic impurities in mixtures,quantative colour measurement and various spectroscopic method for identification of chemical moiety. Qbd developed spectroscopic    and chromatographic method are usually done as per ICH Q8 R2   , the critical parameters are compared to principle observation  and analysis, the HPTLC method employs solvent usage and detection of absorbance and wavelength comparison.

scholarly journals SYSTEM OF THE COMPLICATED PRACTICAL PROBLEMS ANALYSIS

2002 ◽  
Vol 7 (1) ◽  
pp. 83-92
Author(s):  
A. V. Kolesnikov ◽  
O. P. Fedorov
Keyword(s):  
Genetic Algorithms ◽  
Analytical Methods ◽  
Fuzzy Systems ◽  
System Analysis ◽  
Homogeneous Problem ◽  
Knowledge Based Systems ◽  
Knowledge Based ◽  
Inhomogeneous Problems ◽  
Methods Analytical ◽  
Modelling Methods

The original methodology of the system analysis of the inhomogeneous problem is offered, including stages of its reducing to homogeneous parts and selecting for them appropriate toolkits: methods and models. This system applies the accumulated knowledge and the experts skills to refer of each homogeneous problem to one or several alternative classes of modelling methods: analytical methods, statistical methods, artificial neuronets, knowledge based systems, fuzzy systems, genetic algorithms. The knowledge base testing has shown sufficiency and consistency of knowledge for realization of the inhomogeneous problems analysis even in conditions with a low and average distortion in the problem descriptions.

SIMULATION-BASED DESIGN METHOD FOR ROOM AIR CONDITIONER WITH SMALLER DIAMETER COPPER TUBES

2012 ◽  
Vol 20 (03) ◽  
pp. 1250012 ◽  
Author(s):  
GUOLIANG DING ◽  
TAO REN ◽  
YONGXIN ZHENG ◽  
YIFENG GAO ◽  
JI SONG
Keyword(s):  
Heat Exchanger ◽  
Design Method ◽  
Copper Tube ◽  
Air Conditioner ◽  
Air Conditioners ◽  
Knowledge Based ◽  
Simulation Based Design ◽  
Simulation Based ◽  
The Cost

Promoting the use of smaller diameter tube in room air conditioner is beneficial to reduce copper consumption and refrigerant charge, but may cause reduction of air conditioner performance, so a design method is needed. This paper presents a simulation-based design method for air conditioner with smaller diameter tube. The new method combines heat exchanger simulator and knowledge-based evolution method optimizer for designing air conditioner heat exchanger with smaller diameter tube. The simulation-based design method is illustrated in detail by an air conditioner of replacing 7 mm tube indoor unit heat exchanger and 9.52 mm tube outdoor unit heat exchanger with 5 mm tube. Case study shows that the cost of the designed air conditioner with 5 mm copper tube is 17.3% lower than that of the original one while the performance deviation between these two air conditioners is less than 0.7%.

Teaching EndoFLIP Impedance Planimetry to Practicing Endoscopists: An “Into the Fire” Approach to Simulation

2021 ◽  
pp. 155335062110380
Author(s):  
Harry J. Wong ◽  
Bailey Su ◽  
Mikhail Attaar ◽  
Kristine Kuchta ◽  
John G. Linn ◽  
...  
Keyword(s):  
Course Completion ◽  
Performance Score ◽  
Impedance Planimetry ◽  
Functional Lumen Imaging Probe ◽  
Knowledge Based ◽  
Simulation Based ◽  
Hands On ◽  
Technical Proficiency ◽  
Written Test ◽  
Practicing Physicians

Background. There are growing interests from practicing endoscopists to implement the functional lumen imaging probe (FLIP) impedance planimetry system. We present a simulation-based curriculum using an “into the fire” approach with hands-on pre- and post-tests to teach the use of this technology. Methods. The curriculum consists of a series of pre-tests, didactic content, mentored hands-on instructions, and post-tests. Pre- and post-testing included a knowledge-based written test, a confidence survey, and an assessment form specific to the hands-on performance of FLIP. Result. Twenty-two practicing physicians completed the curriculum. After course completion, participants had improved knowledge-based written test scores from 6.8±1.7 to 8.9±0.9 ( P<0.001), confidence scores from 10.0±5.9 to 22.1±2.6 ( P<0.001), and hands-on performance score from 11.4±3.4 to 23.1±2.0 ( P<0.001) with significant improvement in all components of the hands-on skills. Conclusion. Our simulation curriculum is effective in improving confidence, knowledge, and technical proficiency when teaching the use of FLIP to practicing physicians.

scholarly journals Fast and exact single and double mutation-response scanning of proteins

2020 ◽  
Author(s):  
Julian Echave
Keyword(s):  
Analytical Methods ◽  
Point Mutations ◽  
Structural Evolution ◽  
Molecular Complexes ◽  
Single Mutation ◽  
Computational Simulations ◽  
Sensitivity Matrix ◽  
Double Mutation ◽  
Simulation Based ◽  
Protein Research

AbstractStudying the effect of perturbations on protein structure is a basic approach in protein research. Important problems, such as predicting pathological mutations and understanding patterns structural evolution, have been addressed by computational simulations based on modelling mutations as forces and predicting deformations using the Linear Response Approximation. In single mutation-response scanning simulations, a sensitivity matrix is obtained by averaging deformations over point mutations. In double mutation-response scanning simulations, a compensation matrix is obtained by minimizing deformations over pairs of mutations. These very useful simulation-based methods may be too slow to deal with large supra-molecular complexes, such as a ribosome or a virus capsid, or large number of proteins, such as the human proteome, which limits their applicability. To address this issue, I derived analytical closed formulas to calculate the sensitivity and compensation matrices directly, without simulations. Here, I present these derivations and show that the resulting analytical methods are much faster than their simulation counterparts, and that where the simulation methods are approximate, the analytical methods are exact by design.

RESEARCH ON SHIP MANUFACTURABILITY AND EVALUATION METHOD

2011 ◽  
Vol 10 (01) ◽  
pp. 3-10 ◽  
Author(s):  
JIN LI ◽  
HONG YI
Keyword(s):  
Basic Concept ◽  
Evaluation System ◽  
Evaluation Method ◽  
Evaluation Methods ◽  
Shipbuilding Industry ◽  
Knowledge Based ◽  
Simulation Based ◽  
Manufacturability Evaluation

Ship manufacturability is one of the most important works for modern shipbuilding industry. The basic concept of ship manufacturability and its evaluation system are discussed first. Then the characteristics of ship manufacturability are analyzed. One kind of ship manufacturability evaluation (SME) strategy is put forward. Two evaluation methods of ship manufacturability (knowledge-based manufacturability evaluation and simulation-based manufacturability evaluation) are proposed too. With the proposed methods, the ship manufacturability can be evaluated reasonably.

scholarly journals MUHAMMADIYAH: CONTESTING IDEOLOGIES BETWEEN PROGRESSIVE ISLAM AND TRADITIONAL

2021 ◽  
Vol 9 (2) ◽  
pp. 145
Author(s):  
Mursalim Munir ◽  
Usman Jafar ◽  
Barsihannor Barsihannor
Keyword(s):  
Analytical Methods ◽  
Sociological Knowledge ◽  
Historical Perspectives ◽  
Knowledge Based ◽  
Library Research ◽  
Islamic Thought ◽  
Qualitative Descriptive ◽  
Ideological Dimension ◽  
Progressive Islam

The research focuses on examining the dynamics of variants of Islamic thought in Muhammadiyah, especially progressive Islamic thought and conservative Islam. The main objective of this research is to identify how the contestation model of the two variants strengthens its hegemony. To achieve this goal, library research was carried out using qualitative-descriptive-analytical methods and utilizing two approaches, namely historical perspectives and sociological knowledge. Based on the available literature, it is found that two tendencies of thought in Muhammadiyah, namely Progressive Islamic thought and Conservative Islam, contradict each other in areas which in the context of Muhammadiyah are closely related to the ideological dimension, namely the methodology of thought and thought construction. Contestation in this aspect has implications for the emergence of a more practical contestation, namely the efforts to market their ideas and beliefs through organizational structural and cultural channels outside the organizational authority.

Stereo modeling of HVEM specimens by serial tilting and computer graphics

1986 ◽  
Vol 44 ◽  
pp. 34-35
Author(s):  
J.R. McIntosh ◽  
D.L. Stemple ◽  
William Bishop ◽  
G.W. Hannaway
Keyword(s):  
Computer Graphics ◽  
Analytical Methods ◽  
Photographic Film ◽  
Complex Structures ◽  
Multiple Objects ◽  
Multiple Images ◽  
3 Dimensional

EM specimens often contain 3-dimensional information that is lost during micrography on a single photographic film. Two images of one specimen at appropriate orientations give a stereo view, but complex structures composed of multiple objects of graded density that superimpose in each projection are often difficult to decipher in stereo. Several analytical methods for 3-D reconstruction from multiple images of a serially tilted specimen are available, but they are all time-consuming and computationally intense.

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