Characterisation and validation of a murine model of global ischaemia-reperfusion injury

1998 ◽  
pp. 61-68
Author(s):  
Mark S. Sumeray ◽  
Derek M. Yellon
Keyword(s):  
Reperfusion Injury ◽  
Murine Model ◽  
Ischaemia Reperfusion Injury ◽  
Global Ischaemia ◽  
Ischaemia Reperfusion

scholarly journals Azithromycin reduces airway inflammation in a murine model of lung ischaemia reperfusion injury

2008 ◽  
Vol 21 (7) ◽  
pp. 688-695 ◽  
Author(s):  
Nele Geudens ◽  
Lien Timmermans ◽  
Hadewijch Vanhooren ◽  
Bart M. Vanaudenaerde ◽  
Robin Vos ◽  
...  
Keyword(s):  
Reperfusion Injury ◽  
Airway Inflammation ◽  
Murine Model ◽  
Ischaemia Reperfusion Injury ◽  
Ischaemia Reperfusion

scholarly journals The Protective Effect of Zinc Against Liver Ischaemia Reperfusion Injury in a Rat Model of Global Ischaemia

2020 ◽  
Vol 10 (3) ◽  
pp. 228-235 ◽  
Author(s):  
Ernest Cheung ◽  
Mehrdad Nikfarjam ◽  
Louise Jackett ◽  
Damien M. Bolton ◽  
Joseph Ischia ◽  
...  
Keyword(s):  
Protective Effect ◽  
Reperfusion Injury ◽  
Rat Model ◽  
Ischaemia Reperfusion Injury ◽  
Global Ischaemia ◽  
Ischaemia Reperfusion ◽  
Liver Ischaemia

scholarly journals 208 Cardioprotection by the mitochondria-targeted superoxide generator mitoparaquat in a murine model of acute myocardial ischaemia reperfusion injury

Heart ◽  
2017 ◽  
Vol 103 (Suppl 5) ◽  
pp. A138.3-A139
Author(s):  
John Mulvey ◽  
Angela Logan ◽  
Sabine Arndt ◽  
Victoria Pell ◽  
Stuart Caldwell ◽  
...  
Keyword(s):  
Reperfusion Injury ◽  
Myocardial Ischaemia ◽  
Murine Model ◽  
Ischaemia Reperfusion Injury ◽  
Ischaemia Reperfusion

Gene Silencing using siRNA for Preventing Liver Ischaemia-Reperfusion Injury

2018 ◽  
Vol 24 (23) ◽  
pp. 2692-2700 ◽  
Author(s):  
H. Susana Marinho ◽  
Paulo Marcelino ◽  
Helena Soares ◽  
Maria Luísa Corvo
Keyword(s):  
Gene Silencing ◽  
Reperfusion Injury ◽  
Therapeutic Potential ◽  
Major Complication ◽  
Ischaemia Reperfusion Injury ◽  
Small Interference Rna ◽  
Ischaemia Reperfusion ◽  
Promising Therapeutic Approach ◽  
Sirna Therapy

Background: Ischaemia-reperfusion injury (IRI), a major complication occurring during organ transplantation, involves an initial ischemia insult, due to loss of blood supply, followed by an inflammation-mediated reperfusion injury. A variety of molecular targets and pathways involved in liver IRI have been identified. Gene silencing through RNA interference (RNAi) by means of small interference RNA (siRNA) targeting mediators of IRI is a promising therapeutic approach. Objective: This study aims at reviewing the use of siRNAs as therapeutic agents to prevent IRI during liver transplantation. Method: We review the crucial choice of siRNA targets and the advantages and problems of the use of siRNAs. Results: We propose possible targets for siRNA therapy during liver IRI. Moreover, we discuss how drug delivery systems, namely liposomes, may improve siRNA therapy by increasing siRNA stability in vivo and avoiding siRNA off-target effects. Conclusion: siRNA therapeutic potential to preclude liver IRI can be improved by a better knowledge of what molecules to target and by using more efficient delivery strategies.

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