Myelin-Associated Glycoprotein

1997 ◽  
pp. 27-36 ◽  
Author(s):  
Xinghua Yin ◽  
Bruce D. Trapp
Keyword(s):  
Myelin Associated Glycoprotein

Monocytoid B Cell Lymphoma Associated with Antibodies to Myelin-Associated Glycoprotein and Sulphated Glucuronyl Paragloboside

2001 ◽  
Vol 106 (3) ◽  
pp. 130-132 ◽  
Author(s):  
M. Donfrid ◽  
S. Apostolski ◽  
N. Suvajdžić ◽  
G. Janković ◽  
V. Čemerikić-Martinović ◽  
...  
Keyword(s):  
B Cell ◽  
Cell Lymphoma ◽  
B Cell Lymphoma ◽  
Myelin Associated Glycoprotein ◽  
Monocytoid B Cell

Metabolism of Functional Groups Modifying the CNS Myelin-Associated Glycoprotein

1988 ◽  
Vol 51 (5) ◽  
pp. 1646-1650 ◽  
Author(s):  
Arrel D. Toews ◽  
Francis V. White ◽  
Pierre Morell
Keyword(s):  
Functional Groups ◽  
Myelin Associated Glycoprotein

scholarly journals Differential Role of PTEN Phosphatase in Chemotactic Growth Cone Guidance

2013 ◽  
Vol 288 (29) ◽  
pp. 20837-20842 ◽  
Author(s):  
Steven J. Henle ◽  
Lucas P. Carlstrom ◽  
Thomas R. Cheever ◽  
John R. Henley
Keyword(s):  
Growth Cone ◽  
Essential Feature ◽  
Pten Expression ◽  
Spinal Neurons ◽  
Phosphoinositide Phosphatase ◽  
Integrin Clustering ◽  
Myelin Associated Glycoprotein ◽  
Phosphatase And Tensin Homologue ◽  
Regenerative Therapies

Negatively targeting the tumor suppressor and phosphoinositide phosphatase PTEN (phosphatase and tensin homologue) promotes axon regrowth after injury. How PTEN functions in axon guidance has remained unknown. Here we report the differential role of PTEN in chemotactic guidance of axonal growth cones. Down-regulating PTEN expression in Xenopus laevis spinal neurons selectively abolished growth cone chemorepulsion but permitted chemoattraction. These findings persisted during cAMP-dependent switching of turning behaviors. Live cell imaging using a GFP biosensor revealed rapid PTEN-dependent depression of phosphatidylinositol 3,4,5-trisphosphate levels in the growth cone induced by the repellent myelin-associated glycoprotein. Moreover, down-regulating PTEN expression blocked negative remodeling of β1-integrin adhesions triggered by myelin-associated glycoprotein, yet permitted integrin clustering by a positive chemotropic treatment. Thus, PTEN negatively regulates growth cone phosphatidylinositol 3,4,5-trisphosphate levels and mediates chemorepulsion, whereas chemoattraction is PTEN-independent. Regenerative therapies targeting PTEN may therefore suppress growth cone repulsion to soluble cues while permitting attractive guidance, an essential feature for re-forming functional neural circuits.

scholarly journals A rapid procedure for selectively isolating the major glycoprotein from purified rat brain myelin

1977 ◽  
Vol 163 (3) ◽  
pp. 635-637 ◽  
Author(s):  
R H Quarles ◽  
C F Pasnak
Keyword(s):  
Rat Brain ◽  
Aqueous Phase ◽  
The Other ◽  
Insoluble Residue ◽  
Rapid Procedure ◽  
Myelin Associated Glycoprotein ◽  
Chloroform Methanol

Treatment of the chloroform/methanol-insoluble residue of rat brain myelin with lithium 3,5-di-iodosalicylate solubilized the major myelin-associated glycoprotein along with most other proteins and glycoproteins. Equilibration of the extract with phenol resulted in the selective partitioning of the major glycoprotein into the aqueous phase, whereas nearly all of the other proteins and glycoproteins went into the phenol phase.

28 RADIOIMMUNOASSAY FOR THE MYELIN-ASSOCIATED GLYCOPROTEIN IN MULTIPLE SCLEROSIS BRAINS

1981 ◽  
Vol 40 (3) ◽  
pp. 308 ◽  
Author(s):  
D. Johnson ◽  
S. Sato ◽  
R. H. Quarles ◽  
H. deF. Webster ◽  
R. O. Brady
Keyword(s):  
Multiple Sclerosis ◽  
Myelin Associated Glycoprotein
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