Experience with Methionyl Growth Hormone (Somatonorm I) in the United Kingdom

1986 ◽  
pp. 279-286 ◽  
Author(s):  
M. A. Preece ◽  
J. M. Tanner
1990 ◽  
Vol 122 (3) ◽  
pp. 414-416 ◽  
Author(s):  
F. Darendeliler ◽  
P. C. Hindmarsh ◽  
M. A. Preece ◽  
L. Cox ◽  
C. G. D. Brook

Abstract We have performed a retrospective analysis of the pubertal parameters of 134 children with isolated GH insufficiency on GH treatment and compared them to the standards of Tanner and to a recent longitudinal study of growth and development in the United Kingdom. The age at onset of puberty (13.0 years in boys, 12.1 years in girls) was found to be significantly delayed (Mann-Whitney p<0.001), but duration of puberty (1.5 years in both sexes) was shortened (Kolgomarov-Smirnov p<0.01). Skeletal maturity at the onset of puberty was not advanced excluding this as a contributory factor. There was no association between dose of GH administered and the pubertal parameters. The results suggest that GH accelerates the pubertal process.


2009 ◽  
pp. 1-6 ◽  
Author(s):  
Nishan Fernando ◽  
Gordon Prescott ◽  
Jennifer Cleland ◽  
Kathryn Greaves ◽  
Hamish McKenzie

1990 ◽  
Vol 35 (8) ◽  
pp. 800-801
Author(s):  
Michael F. Pogue-Geile

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