Comparative Potency of Complex Mixtures: Use of Short-Term Genetic Bioassays in Cancer Risk Assessment

1985 ◽  
pp. 363-375
Author(s):  
Joellen Lewtas
Keyword(s):  
Risk Assessment ◽  
Cancer Risk ◽  
Complex Mixtures ◽  
Cancer Risk Assessment ◽  
Short Term

Development of a Comparative Potency Method for Cancer Risk Assessment of Complex Mixtures Using Short-Term in Vivo and in Vitro Bioassays

1985 ◽  
Vol 1 (4) ◽  
pp. 193-203 ◽  
Author(s):  
Joellen Lewtas
Keyword(s):  
Risk Assessment ◽  
Cancer Risk ◽  
Data Base ◽  
Complex Mixtures ◽  
Cancer Risk Assessment ◽  
Human Lung Cancer ◽  
Short Term ◽  
Coke Ovens

A comparative potency method for cancer risk assessment has been developed based on a constant relative potency hypothesis. This method was developed and tested using data from a battery of short-term mutagenesis bioassays, animal tumorigenicity data and human lung cancer risk estimations. This data base was developed for a series of complex mixtures including emissions from coke ovens, roofing tar pots, cigarette smoke and automotive engines. The series of automobiles used in this study included both diesel- and gasoline-powered vehicles. The assumptions inherent in this method are discussed, together with the methods and data base used to test these assumptions.

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