Clinical Studies in the Selection of Patients for Coronary Artery Surgery

1973 ◽  
pp. 243-247 ◽  
Author(s):  
Thomas B. Ferguson ◽  
Clarence S. Weldon
Keyword(s):  
Coronary Artery ◽  
Clinical Studies ◽  
Coronary Artery Surgery ◽  
Selection Of Patients ◽  
Selection Of

Hyperbaric oxygen therapy and the diabetic foot

1997 ◽  
Vol 87 (6) ◽  
pp. 279-292 ◽  
Author(s):  
RL Williams
Keyword(s):  
Wound Healing ◽  
Hyperbaric Oxygen ◽  
Diabetic Foot ◽  
Hyperbaric Oxygen Therapy ◽  
Clinical Studies ◽  
Oxygen Therapy ◽  
Diabetic Patients ◽  
Selection Of Patients ◽  
Selection Of

Hyperbaric oxygen therapy is an adjunctive wound-healing modality receiving increasing use for problem wounds, particularly diabetic foot wounds. Nevertheless, few clinicians understand the physiologic basis for this modality; how patients are selected, or the expected results. The author reviews the development of hyperbaric oxygen therapy, selection of patients, and clinical studies of this modality for diabetic patients with foot wounds.

scholarly journals Multimodal Magnetic Resonance Imaging for Assessing Evolution of Ischemic Penumbra: A Key Translational Medicine Strategy to Manage the Risk of Developing Novel Therapies for Acute Ischemic Stroke

2008 ◽  
Vol 29 (1) ◽  
pp. 217-219 ◽  
Author(s):  
Juan C Chavez ◽  
Margaret M Zaleska ◽  
Xinkang Wang ◽  
Andrew Wood ◽  
Orest Hurko ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Clinical Studies ◽  
Translational Medicine ◽  
Novel Therapies ◽  
Clinical Failure ◽  
Ischemic Penumbra ◽  
Resonance Imaging ◽  
Spatiotemporal Evolution ◽  
Selection Of Patients ◽  
Selection Of

The implicit aim of neuroprotection is to rescue neurons within distressed but still viable tissue, thereby promoting functional recovery upon neuronal salvage. The clinical failure of this approach suggests that previous efforts to develop stroke therapies lacked means to predict success or futility in pre-clinical and early clinical studies. A key translational medicine strategy that can improve predictability relies on imaging methodologies to map the spatiotemporal evolution of the ischemic penumbra. This could serve as a biomarker indicative of neuroprotective potential and could increase likelihood of success in clinical studies by allowing selection of patients who are most likely to respond to therapy.

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