Recent Advances in the Study of Molecular-Genetic Mechanisms of Development

1970 ◽  
pp. 391-410
Author(s):  
Zhores A. Medvedev
Keyword(s):  
Molecular Genetic ◽  
Recent Advances ◽  
Genetic Mechanisms ◽  
Mechanisms Of Development

scholarly journals Cilia-mediated Hedgehog signaling controls form and function in the mammalian larynx

eLife ◽  
2017 ◽  
Vol 6 ◽  
Author(s):  
Jacqueline M Tabler ◽  
Maggie M Rigney ◽  
Gordon J Berman ◽  
Swetha Gopalakrishnan ◽  
Eglantine Heude ◽  
...  
Keyword(s):  
Hedgehog Signaling ◽  
Animal Communication ◽  
Molecular Genetic ◽  
Form And Function ◽  
Vocal Apparatus ◽  
Important Challenge ◽  
Genetic Mechanisms ◽  
Basic Biology ◽  
Mechanisms Of Development ◽  
And Function

Acoustic communication is fundamental to social interactions among animals, including humans. In fact, deficits in voice impair the quality of life for a large and diverse population of patients. Understanding the molecular genetic mechanisms of development and function in the vocal apparatus is thus an important challenge with relevance both to the basic biology of animal communication and to biomedicine. However, surprisingly little is known about the developmental biology of the mammalian larynx. Here, we used genetic fate mapping to chart the embryological origins of the tissues in the mouse larynx, and we describe the developmental etiology of laryngeal defects in mice with disruptions in cilia-mediated Hedgehog signaling. In addition, we show that mild laryngeal defects correlate with changes in the acoustic structure of vocalizations. Together, these data provide key new insights into the molecular genetics of form and function in the mammalian vocal apparatus.

scholarly journals Molecular-genetic mechanisms in development of degree of function and hyperplasia of thyroid gland of patients with nodular goiter with autoimmune thyroiditis and thyroid adenoma

2019 ◽  
Vol 14 (3) ◽  
pp. 255-262
Author(s):  
Michael I. Sheremet ◽  
◽  
Larisa P. Sydorchuk ◽  
Viktor O. Shidlovskyi ◽  
Olexandr V. Shidlovskyi ◽  
...  
Keyword(s):  
Thyroid Gland ◽  
Autoimmune Thyroiditis ◽  
Molecular Genetic ◽  
Nodular Goiter ◽  
Thyroid Adenoma ◽  
Genetic Mechanisms

scholarly journals Comparative transcriptome analysis of mule uncovered several heterosis-related genes for improving muscular endurance and cognition

2019 ◽  
Author(s):  
Shan Gao
Keyword(s):  
Alternative Splicing ◽  
Molecular Genetic ◽  
Hybrid Vigor ◽  
Neuronal System ◽  
Future Studies ◽  
Genome Wide ◽  
A Genome ◽  
Genetic Mechanisms ◽  
Productive Traits ◽  
Genome Wide Gene Expression

AbstractHeterosis has been widely exploited in animal and plant breeding to enhance the productive traits of hybrid progeny of two breeds or two species. Although, there were multiple models for explaining the hybrid vigor, such as dominance and over-dominance hypothesis, its underlying molecular genetic mechanisms remain equivocal. The aim of this study is through comparing the different expression genes (DEGs) and different alternative splicing (DAS) genes to explore the mechanism of heterosis. Here, we performed a genome-wide gene expression and alternative splicing analysis of two heterotic crosses between donkey and horse in three tissues. The results showed that the DAS genes influenced the heterosis-related phenotypes in a unique than DEGs and about 10% DEGs are DAS genes. In addition, over 69.7% DEGs and 87.2% DAS genes showed over-dominance or dominance, respectively. Furthermore, the “Muscle Contraction” and “Neuronal System” pathways were significantly enriched both for the DEGs and DAS genes in muscle. TNNC2 and RYR1 genes may contribute to mule’s great endurance while GRIA2 and GRIN1 genes may be related with mule’s cognition. Together, these DEGs and DAS genes provide the candidates for future studies of the genetic and molecular mechanism of heterosis in mule.

scholarly journals Systemic and molecular-genetic mechanisms of cardioprotection

2011 ◽  
Vol 5 (57) ◽  
pp. 51-54
Author(s):  
AA Moĭbenko ◽  
Keyword(s):  
Molecular Genetic ◽  
Genetic Mechanisms

Clinical phenotypes and molecular genetic mechanisms of Carney complex

2005 ◽  
Vol 6 (7) ◽  
pp. 501-508 ◽  
Author(s):  
David Wilkes ◽  
Deborah A McDermott ◽  
Craig T Basson
Keyword(s):  
Molecular Genetic ◽  
Carney Complex ◽  
Clinical Phenotypes ◽  
Genetic Mechanisms
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