scholarly journals Molecular-genetic mechanisms in development of degree of function and hyperplasia of thyroid gland of patients with nodular goiter with autoimmune thyroiditis and thyroid adenoma

2019 ◽  
Vol 14 (3) ◽  
pp. 255-262
Author(s):  
Michael I. Sheremet ◽  
◽  
Larisa P. Sydorchuk ◽  
Viktor O. Shidlovskyi ◽  
Olexandr V. Shidlovskyi ◽  
...  
Keyword(s):  
Thyroid Gland ◽  
Autoimmune Thyroiditis ◽  
Molecular Genetic ◽  
Nodular Goiter ◽  
Thyroid Adenoma ◽  
Genetic Mechanisms

scholarly journals Az autoimmun thyreoiditis, a kétoldali papillaris pajzsmirigy-carcinoma, a nyaki thyreolipoma és a diabetes mellitus együttes előfordulása

2018 ◽  
Vol 159 (25) ◽  
pp. 1024-1032
Author(s):  
Tamás Steiner ◽  
Ilona Péter ◽  
Péter Pogány ◽  
András Lantos ◽  
Zsuzsa Sándor ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Adipose Tissue ◽  
Thyroid Gland ◽  
Papillary Carcinoma ◽  
Autoimmune Thyroiditis ◽  
Histopathological Examination ◽  
Fibrous Capsule ◽  
Thyroid Adenoma ◽  
Rare Form ◽  
Mature Adipose Tissue

Abstract: Thyrolipoma or thyroid adenolipoma is an extremely rare form of thyroid adenoma, which also contains mature adipose tissue and follicles covered with fibrous capsule. We present the case of the growing cervical lesion of a 52-year-old female with diabetes, which was removed during total thyreoidectomy. Autoimmune thyroiditis, bilateral papillary carcinoma and cervical thyrolipoma have been identified by the histopathological examination of the thyroid gland. Orv Hetil. 2018; 159(25): 1024–1032.

scholarly journals Peculiarities of operative treatment of goiter on background of autoimmune thyroiditis

2020 ◽  
Vol 87 (1-2) ◽  
pp. 43-46
Author(s):  
O. P. Kovalov ◽  
O. M. Liulka ◽  
V. I. Liakhovskyi ◽  
I. I. Nemchenko ◽  
A. V. Sydorenko
Keyword(s):  
Surgical Treatment ◽  
Thyroid Gland ◽  
Autoimmune Thyroiditis ◽  
Malignant Tumors ◽  
Laboratory Data ◽  
Clinical Signs ◽  
Endocrine System ◽  
Nodular Goiter ◽  
Subtotal Resection ◽  
Retrosternal Goiter

Objective. To determine the peculiarities of operative technique in surgical treatment of patients with nodular goiter on background of autoimmune thyroiditis. Materials and methods. The results of surgical treatment of nodular goiter, basing on data from surgical clinic of the Second Clinical Hospital in City of Poltava through 2003 - 2017 yrs were adduced. There were operated 549 patients, suffering nodular goiter. There were 58 (10.6%) men and 491 (89.4%) women. Unilateral nontoxic nodular goiter was observed in 187 (34.1%) patients, multinodular nontoxic – in 322 (58.7%), multinodular toxic – in 30 (5.5%), thyreotoxic adenoma – in 21 (3.8%) patients. Cervico-retrosternal goiter was in 110 (20.0%) patients. For recurrent goiter 21 (3.8%) patients were operated. Malignant tumors were revealed intraoperatively or after definite histological investigation in 22 (4/0%) patients. Of 108 patients, to whom, basing on the disease clinical signs, laboratory data and preoperative cytological investigation the diagnosis of nodular goiter on background of autoimmune thyroiditis was established, while performing of definite postoperative investigation macromicrofollicular colloidal goiter was revealed in 41 (38%), nodular goiter with the autoimmune thyroiditis – in 51 (47.2%), cancer (papillary, follicular) – in 8 (14.8%) patients. Subtotal resection of thyroid gland was performed in 8 (15.7%) patients, hemithyroidectomy - in 12 (23.5%), extrafascial thyroidectomy – in 23 (45.1%). In patients, suffering thyroidal gland cancer, extrafascial thyroidectomy was performed, while in 3 – with central lymphodissection. Intraoperatively visual macroscopic estimation of thyroid gland and obligatory suboperative cyto- and histological investigations of the specimen obtained were performed. Operative tactics was applied in accordance to actual clinical protocols for treatment of patients, suffering surgical pathology of endocrine system. Results. Some technical measures were proposed to minimize the risk of injury of anatomic structures: lower laryngeal nerve, parathyroidal glands, trachea, the neck vessels. Conclusion. Extrafascial procedure guarantees a visual control in the risk zones and radicality of operation, minimizes the specific complications rate.

scholarly journals Caspase-3 and Caspase-8 in Patients with Nodular Goiter and Autoimmune Thyroiditis

2016 ◽  
Vol 23 (3) ◽  
Author(s):  
M. I. Sheremet ◽  
V. O. Shidlovskyy ◽  
L. P. Sydorchuk ◽  
R. I. Sydorchuk
Keyword(s):  
Antioxidant Enzymes ◽  
Autoimmune Thyroiditis ◽  
Caspase 3 ◽  
Nodular Goiter ◽  
Oxidative Modification ◽  
Caspase 8 ◽  
Thyroid Adenoma ◽  
Protein Oxidative Modification ◽  
Peroxidation Processes ◽  
Abnormal Tissue

The article presents results of the comparative analysis of peroxidation process activity of caspase-3 and caspase-8 in patients with thyroid adenoma (TA) and nodular goiter with autoimmune thyroiditis (NGAIT). Studying peroxidation processes in the tissue of the thyroid gland abnormal tissue was detected to be characterized by increase in of protein oxidative modification (POM) indices at the same time, the antioxidant enzymes activity (AEA) was significantly reduced and was more likely in patients with NGAIT. Significant increase in activity of both caspase 3 and 8 was shown in patients with NGAIT compared to macroscopically unchanged tissue and thyroid adenoma. Possible mechanisms of the detected disorders were discussed.

THYROID CYTOLOGY AND IT'S INTERPRETATION WITH THYROID FUNCTION TEST

2021 ◽  
pp. 80-82
Author(s):  
Dipti Debbarma ◽  
Shipra Singh ◽  
Debarshi Jana ◽  
Chittaranjan Dutta
Keyword(s):  
Thyroid Gland ◽  
Thyroid Function ◽  
Nodular Goiter ◽  
Thyroid Function Test ◽  
Total Serum ◽  
Endocrine Glands ◽  
Nodular Goitre ◽  
Medical College ◽  
Euthyroid State ◽  
Function Test

INTRODUCTION: The Thyroid gland is unique among the endocrine glands. It is the largest of all the endocrine glands and it is supercial in location. It is the only gland which is easily approachable to direct physical, cytological and histopathological examination. The thyroid gland is affected by a variety of pathological lesions that are manifested by various morphologies including developmental, inammatory, hyperplastic and neoplastic pathology which are quiet common in the clinical practice. AIM OFTHE STUDY:In this study, we aimed to assess the cytological ndings of palpable thyroid nodules in conjunction with thyroid hormonal prole of the patient. To study the incidence in relevance to age, sex in various categories of thyroid lesions. MATERIALS & METHODS: Study Design: Institutional based Cross-sectional Study. Duration of study: January 2019 to August 2020. Source of data: Patients presenting to the OPD and admitted in the In-patient ward at Darbhanga Medical College, Bihar. Place of study: Department of Pathology, Darbhanga Medical College and Hospital, Laheriasarai, Bihar. Sample Size: 60 patients of enlarged thyroid gland. RESULTS & OBSERVATIONS: We found that the 53.3% Patients are in euthyroid state. Nodular goitre is the most common nding. In the present study among 60 patients, Nodular goiter accounts for 83.3 % of all cases; 41.7% of them were in euthyroid state, 21.7 % in hypothyroid state , 8.3 % in subclinical hypothyroid and remaining 11.7 % in hyperthyroid state . SUMMARY AND CONCLUSION: FNAC together with thyroid function test (TFT) analysis leads to early and accurate diagnosis of various thyroid diseases and reduces surgical intervention. The study showed that FNAcytologic diagnosis cannot be used to predict thyroid function using total serum T4, T3 and TSH concentrations. Measurement of TSH, free T4, and free T3 would be preferable

NODULAR GOITER AND MALIGNANT LESIONS OF THE THYROID GLAND*

1951 ◽  
Vol 11 (10) ◽  
pp. 1157-1165 ◽  
Author(s):  
OLIVER H. BEAHRS ◽  
JOHN DEJ. PEMBERTON ◽  
B. MARDEN BLACK
Keyword(s):  
Thyroid Gland ◽  
Nodular Goiter ◽  
Malignant Lesions

scholarly journals Certain peculiarities of parenchymal-stromal correlations in the thyroid gland with nodular forms of goiter with its rucurrent and non-recurrent course

2020 ◽  
Vol 19 (1) ◽  
pp. 53-60
Author(s):  
N. P. Tkachuk ◽  
I. S. Davydenko
Keyword(s):  
Thyroid Gland ◽  
Slow Growth ◽  
Thyroid Tissue ◽  
Nodular Goiter ◽  
Specific Weight ◽  
Pathological Changes ◽  
Normal Thyroid Tissue ◽  
Normal Thyroid ◽  
Stromal Component ◽  
Correlation Parameters

In spite of a considerable efficacy of conservative treatment of goiter, surgery remains the main method of treatment of such patients. Though, on the one hand, total thyroidectomy inevitably results in the development of postsurgical hypothyroidism, on the other hand – in case organ-saving surgery is performed the risk of postsurgical relapse arises. Modern morphological methods are directed to detection of oncological risk of nodular formations, and recommendations concerning an adequate volume of surgery taking into account probability of relapse are practically lacking. Therefore, the objective of the study was finding criteria of a relapsing risk by means of investigation of morphological peculiarities of the parenchymal-stromal correlations in the thyroid gland with recurrent nodular and primary nodular (multinodular) goiter without signs of functional disorders. In the course of the research according to the examined correlation parameters of the parenchyma and stroma various forms of nodular goiter were found to differ from the thyroid tissue without pathological changes by a number of parameters. In particular, specific weight of the parenchyma on an average increases reliably in the tissue of nodular goiter with its various variants in comparison with the thyroid gland without pathological changes. Together with the increase of the parenchymal specific weight in nodular goiter the amount of colloid on an average decreases, and a specific dependence on the kind of goiter is observed – colloid volume decreases from goiter with slow growth to goiter with quick growth, and it is the smallest with goiter relapse. Quantitative analysis of the goiter tissue stromal component demonstrates a considerable increase of its specific volume in comparison with normal thyroid tissue. Evaluation of changes of the morphometric parameters in the thyroid follicles found that in case of nodular goiter with slow growth the percentage of follicles with colloid is close to 100%. On an average it does not differ from that of the normal thyroid tissue. At the same time, in case of nodular goiter with quick growth the percentage of follicles with colloid decreases sharply, and in case of relapse it appears to be still less than that in nodular goiter with quick growth. Besides, with nodular goiter the diameter of follicles on an average increases in comparison with the normal thyroid tissue. In a number of cases it can be estimated as macrofollicular goiter. At the same time, the diameter of follicles is smaller in nodular goiter with quick growth. It is still less in case of goiter relapse. The size of follicles becomes sharply diverse in case of nodular goiter with slow growth, but it decreases in case of nodular goiter with quick growth and relapse. Consequently, recurrent nodular goiter is mostly similar to that of primary nodular goiter with a quick growth, though certain differences between them exist. The peculiarities found enable to suggest that nodular goiter with a quick growth possesses more chances for relapse.

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