Muscarinic and Nicotinic Receptors in Alzheimer’s Disease: Rationale for Cholinergic Drug Treatment

1989 ◽  
pp. 53-61 ◽  
Author(s):  
Paul A. Lapchak ◽  
Dalia M. Araujo ◽  
Remi Quirion
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Drug Treatment ◽  
Nicotinic Receptors ◽  
Muscarinic And Nicotinic Receptors ◽  
Cholinergic Drug

scholarly journals Designing Hybrids Targeting the Cholinergic System by Modulating the Muscarinic and Nicotinic Receptors: A Concept to Treat Alzheimer’s Disease

Molecules ◽  
2018 ◽  
Vol 23 (12) ◽  
pp. 3230 ◽  
Author(s):  
Daniela Volpato ◽  
Ulrike Holzgrabe
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cholinergic System ◽  
Nicotinic Receptors ◽  
Behavioral Issues ◽  
Bifunctional Compounds ◽  
Molecule Design ◽  
Review Reports ◽  
Muscarinic And Nicotinic Receptors

The cholinergic hypothesis has been reported first being the cause of memory dysfunction in the Alzheimer’s disease. Researchers around the globe have focused their attention on understanding the mechanisms of how this complicated system contributes to processes such as learning, memory, disorientation, linguistic problems, and behavioral issues in the indicated chronic neurodegenerative disease. The present review reports recent updates in hybrid molecule design as a strategy for selectively addressing multiple target proteins involved in Alzheimer’s disease (AD) and the study of their therapeutic relevance. The rationale and the design of the bifunctional compounds will be discussed in order to understand their potential as tools to investigate the role of the cholinergic system in AD.

scholarly journals Upregulation of astrocytic α7 nicotinic receptors in Alzheimer's disease brain- possible relevant to amyloid pathology

2012 ◽  
Vol 7 (Suppl 1) ◽  
pp. O7 ◽  
Author(s):  
Wenfeng Yu ◽  
Naguib Mechawar ◽  
Slavica Krantic ◽  
Jean-Guy Chabot ◽  
Rémi Quirion
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Nicotinic Receptors ◽  
Amyloid Pathology

scholarly journals Drug treatment for early Alzheimer's disease

1998 ◽  
Vol 4 (3) ◽  
pp. 126-134 ◽  
Author(s):  
Roger Bullock
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Molecular Biology ◽  
Drug Treatment ◽  
21St Century ◽  
Chronic Conditions ◽  
Epidemiological Studies ◽  
Early Alzheimer’S Disease

Alzheimer's disease is likely to be one of the challenges for the early part of the 21st century. Better knowledge of the molecular biology, genetics and pathogenesis of the condition have led to a host of psychopharmacological compounds being developed which may help in its the treatment, while epidemiological studies have suggested that existing treatments for other chronic conditions may have an effect on the presentation of Alzheimer's disease.

scholarly journals A spatial covariance 123 I-5IA-85380 SPECT study of α4β2 nicotinic receptors in Alzheimer's disease

2016 ◽  
Vol 47 ◽  
pp. 83-90 ◽  
Author(s):  
Sean J. Colloby ◽  
Robert H. Field ◽  
David J. Wyper ◽  
John T. O'Brien ◽  
John-Paul Taylor
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Nicotinic Receptors ◽  
Spatial Covariance

Alzheimer's disease: Changes in the cerebrocortical expression of nicotinic receptors on the protein level

1998 ◽  
Vol 92 (5-6) ◽  
pp. 509-510
Author(s):  
A. Wevers ◽  
S. Nowacki ◽  
J. Lindstrom ◽  
U. Schütz ◽  
E. Giacobini ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Protein Level ◽  
Nicotinic Receptors
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