Potential Pharmacological Use of Neurotrophic Factors in the Treatment of Neurodegenerative Diseases

1989 ◽  
pp. 63-70 ◽  
Author(s):  
Franz Hefti
Keyword(s):  
Neurodegenerative Diseases ◽  
Neurotrophic Factors

scholarly journals Does Irisin Link Physical Exercise with Alzheimer’s Disease?

2018 ◽  
Author(s):  
Dewan Md. Sumsuzzman ◽  
Yunho Jin ◽  
Jeonghyun Choi ◽  
Sang-Rae Lee ◽  
Yonggeun Hong
Keyword(s):  
Skeletal Muscle ◽  
Physical Exercise ◽  
Neurodegenerative Diseases ◽  
Telomere Length ◽  
Neurotrophic Factors ◽  
Therapeutic Target ◽  
Potential Role ◽  
Human Diseases ◽  
Nervous Systems ◽  
Beneficial Effects

Irisin, a skeletal muscle-secreted myokine, produced in response to physical exercise, has protective functions in both the central and the peripheral nervous systems, including the regulation of brain-derived neurotrophic factors and modification of telomere length. Such beneficial effects may inhibit or delay the emergence of neurodegenerative diseases, including Alzheimer’s disease (AD). This review is based on the hypothesis that irisin produced by physical exercise helps control AD progression. Herein, we describe the physiology of irisin and its potential role in delaying or preventing AD. Although current and ongoing studies on irisin show promising results, further research is required to clarify its potential as a meaningful therapeutic target for treating human diseases.

Discovering novel phenotype-selective neurotrophic factors to treat neurodegenerative diseases

2004 ◽  
pp. 167-183 ◽  
Author(s):  
Penka S. Petrova ◽  
Andrei Raibekas ◽  
Jonathan Pevsner ◽  
Noel Vigo ◽  
Mordechai Anafi ◽  
...  
Keyword(s):  
Neurodegenerative Diseases ◽  
Neurotrophic Factors

Therapeutic Potential of Neurotrophic Factors in Neurodegenerative Diseases

BioDrugs ◽  
2005 ◽  
Vol 19 (2) ◽  
pp. 97-127 ◽  
Author(s):  
Yossef S Levy ◽  
Yossi Gilgun-Sherki ◽  
Eldad Melamed ◽  
Daniel Offen
Keyword(s):  
Neurodegenerative Diseases ◽  
Neurotrophic Factors ◽  
Therapeutic Potential
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