Morphological Analysis of Chick Embryo Heart Development

Author(s):  
L. Sisto-Daneo ◽  
G. Filogamo
1961 ◽  
Vol 39 (5) ◽  
pp. 925-932 ◽  
Author(s):  
Helen J. Morton ◽  
Joseph F. Morgan

Seventeen structurally related compounds were tested for their ability to substitute for phenylalanine or tyrosine in the nutrition of chick embryo heart fragments. DL-Alanyl-DL-phenylalanine replaced phenylalanine. All other compounds had negligible effects, and most were toxic at high concentrations. β-Phenylserine, a phenylalanine antagonist, actually prolonged the survival of chick heart cells but only if both phenylalanine and tyrosine were present. Similarly, optimal reversal of β-phenylserine toxicity was dependent on the presence of both amino acids. Although phenylalanine and tyrosine are not interconvertible in the present system, it has been shown that three phenylalanine antagonists, p-fluorophenylalanine, β-2-thienylalanine, and β-phenylserine, can be identified by their relationship to tyrosine, rather than to phenylalanine.


1959 ◽  
Vol 7 (5) ◽  
pp. 787-793 ◽  
Author(s):  
ROBERT J. BOUCEK ◽  
WILLIAM P. MURPHY ◽  
GEORGE H. PAFF

Sign in / Sign up

Export Citation Format

Share Document