The Role of H-2 Gene Complex in Experimental Autoimmune Thyroiditis

H-2 Antigens ◽  
1987 ◽  
pp. 769-778 ◽  
Author(s):  
Yi-chi M. Kong ◽  
Chella S. David
Keyword(s):  
Autoimmune Thyroiditis ◽  
Gene Complex ◽  
Experimental Autoimmune Thyroiditis ◽  
Experimental Autoimmune

scholarly journals Death Ligand Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand Inhibits Experimental Autoimmune Thyroiditis

Endocrinology ◽  
2005 ◽  
Vol 146 (11) ◽  
pp. 4721-4726 ◽  
Author(s):  
Su He Wang ◽  
Zhengyi Cao ◽  
Julie M. Wolf ◽  
Mary Van Antwerp ◽  
James R. Baker
Keyword(s):  
Autoimmune Thyroiditis ◽  
T Helper ◽  
Mononuclear Cell Infiltration ◽  
T Helper 1 ◽  
Experimental Autoimmune Thyroiditis ◽  
Cell Responses ◽  
Control Protein ◽  
Necrosis Factor ◽  
Experimental Autoimmune

The role of TNF-related apoptosis-inducing ligand (TRAIL) in autoimmune thyroiditis is unclear. We used experimental autoimmune thyroiditis to clarify the contribution of TRAIL to the development of autoimmune thyroiditis. CBA/J mice were immunized with murine thyroglobulin, and spleen cells from these mice were subsequently injected into irradiated recipient CBA/J mice. One week later, the recipient mice were treated with recombinant TRAIL or a control protein. Compared with control animals, TRAIL-treated mice developed a milder form of the disease with a significant decrease in mononuclear cell infiltration in the thyroid and less thyroid follicular destruction. Furthermore, the number of apoptotic thyrocytes and also thyroglobulin-specific T helper-1 cell responses in TRAIL-treated mice was lower than that in the control animals. This study suggests that exogenous TRAIL suppresses the development of autoimmune thyroiditis via altering the function of cells involved in the immune response. These findings may contribute toward a novel treatment autoimmune thyroiditis.

Unique role of thyroxine in T cell recognition of a pathogenic peptide in experimental autoimmune thyroiditis

1996 ◽  
Vol 26 (4) ◽  
pp. 768-772 ◽  
Author(s):  
Kim I. Dawe ◽  
Patricia R. Hutchings ◽  
Mario Geysen ◽  
Brian R. Champion ◽  
Anne Cooke ◽  
...  
Keyword(s):  
T Cell ◽  
Autoimmune Thyroiditis ◽  
Cell Recognition ◽  
Experimental Autoimmune Thyroiditis ◽  
Unique Role ◽  
T Cell Recognition ◽  
Experimental Autoimmune

scholarly journals Regenerative Potentials of the Murine Thyroid in Experimental Autoimmune Thyroiditis: Role of CD24

Endocrinology ◽  
2008 ◽  
Vol 150 (1) ◽  
pp. 492-499 ◽  
Author(s):  
Cindy Y. Chen ◽  
Hiroaki Kimura ◽  
Melissa A. Landek-Salgado ◽  
Judith Hagedorn ◽  
Miho Kimura ◽  
...  
Keyword(s):  
Stem Cells ◽  
Autoimmune Thyroiditis ◽  
Hashimoto Thyroiditis ◽  
Experimental Autoimmune Thyroiditis ◽  
Normal Morphology ◽  
And Function ◽  
Infiltrating Lymphocytes ◽  
Experimental Autoimmune

Hashimoto thyroiditis can be partially reproduced in mice by immunization with thyroglobulin or, more recently, thyroperoxidase. This experimental autoimmune thyroiditis (EAT) model has been extensively characterized during early disease phases (up to d 35 after immunization). By extending the analysis of EAT to 100 d after immunization, we noted a remarkable regenerative capacity of the thyroid and the expression of Oct-4, suggesting in vivo the existence of adult thyroid stem cells. After an almost complete destruction of the follicular architecture, occurring between d 21 and 28, the thyroid was capable of restoring its follicles and reducing the mononuclear infiltration, so that by d 100 after immunization, it regained its normal morphology and function. During this regeneration process, thyrocytes expressed high levels of CD24. We therefore assessed the role of CD24 in thyroid regeneration by inducing EAT in mice lacking CD24. Regeneration was faster in the absence of CD24, likely a consequence of the effect of CD24 on the infiltrating lymphocytes. The study suggests that the EAT model can also be used as a tool to investigate adult thyroid stem cells. The murine thyroid is capable of restoring its architecture after an insult that almost completely destroys it.

scholarly journals THE ROLE OF MYCOBACTERIA AND THE EFFECT OF PROTEOLYTIC DEGRADATION OF THYROGLOBULIN ON THE PRODUCTION OF AUTOIMMUNE THYROIDITIS

1969 ◽  
Vol 130 (2) ◽  
pp. 243-262 ◽  
Author(s):  
W. O. Weigle ◽  
Gloria J. High ◽  
R. M. Nakamura
Keyword(s):  
Autoimmune Thyroiditis ◽  
Proteolytic Enzymes ◽  
Ion Concentration ◽  
Experimental Autoimmune Thyroiditis ◽  
Hydrogen Ion Concentration ◽  
Initial Event ◽  
Local Areas ◽  
Experimental Autoimmune

Data are presented which suggest that the initial event involved in experimental autoimmune thyroiditis following injection of rabbits with homologous thyroglobulin in complete Freund's adjuvant is alteration of the thyroglobulin. Alteration of the thyroglobulin does not occur during incorporation into the adjuvant or in vitro storage in the adjuvant, and the mycobacteria in the adjuvant have no direct effect on the thyroglobulin. Most likely, the alteration results from an increase in hydrogen ion concentration within cells or local areas in the granuloma and the subsequent action of proteolytic enzymes. These conditions are probably established in the granuloma as the result of neutrophilic response to the mycobacteria in the adjuvant. Rabbits injected with aqueous preparations of homologous thyroglobulin partially degraded in vitro with pepsin at acid pH produced antibody to native thyroglobulin and developed thyroiditis. Most of these rabbits responded to a subsequent injection of native thyroglobulin given 1 month later.

The role of cellular proliferation in the induction of experimental autoimmune thyroiditis (EAT) in mice

1986 ◽  
Vol 103 (1) ◽  
pp. 96-104 ◽  
Author(s):  
William V. Williams ◽  
Michael Kyriakos ◽  
Gordon C. Sharp ◽  
Helen Braley-Mullen
Keyword(s):  
Autoimmune Thyroiditis ◽  
Cellular Proliferation ◽  
Experimental Autoimmune Thyroiditis ◽  
Experimental Autoimmune

Role of Late Complement Components in Experimental Autoimmune Thyroiditis

1993 ◽  
Vol 66 (1) ◽  
pp. 1-10 ◽  
Author(s):  
K. Inoue ◽  
N. Niesen ◽  
G. Biesecker ◽  
F. Milgrom ◽  
B. Albini
Keyword(s):  
Autoimmune Thyroiditis ◽  
Experimental Autoimmune Thyroiditis ◽  
Complement Components ◽  
Experimental Autoimmune
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