Molecular Studies on the Role of Dietary Fat and Cholesterol in Breast Cancer Induction

1997 ◽  
pp. 39-46 ◽  
Author(s):  
Michael C. Archer ◽  
Ahmed El-Sohemy ◽  
Laurie L. Stephen ◽  
Alaa F. Badawi
Keyword(s):  
Breast Cancer ◽  
Dietary Fat ◽  
Cancer Induction ◽  
Molecular Studies

Lifelong exposure to n-3 PUFA affects pubertal mammary gland development

2014 ◽  
Vol 39 (6) ◽  
pp. 699-706 ◽  
Author(s):  
Breanne M. Anderson ◽  
Mira B. MacLennan ◽  
Lyn M. Hillyer ◽  
David W.L. Ma
Keyword(s):  
Breast Cancer ◽  
Mammary Gland ◽  
Breast Cancer Risk ◽  
Cancer Risk ◽  
Dietary Fat ◽  
Mammary Gland Development ◽  
Morphological Development ◽  
Terminal End Buds ◽  
Gland Development

There is growing evidence that early developmental periods may importantly influence future breast cancer risk. Also, there is great interest in the role of dietary fat in breast cancer risk, but the role of dietary fat during pubertal mammary gland development remains poorly understood. This study investigated the effect of n-3 polyunsaturated fatty acids (PUFA) using complementary dietary and genetic approaches to examine the effect of lifelong exposure of n-3 PUFA or n-6 PUFA (control) on mammary gland development and fatty acid composition. n-3 PUFA from both diet and genetics were enriched in mammary glands as early as 3 weeks of age. Parameters related to mammary gland development, including number of terminal end buds (TEB), percent coverage of ductal tree, and infiltration of TEB, were influenced by n-3 PUFA at 3 and 4 weeks of age. Overall, findings suggest that n-3 PUFA incorporation into the mammary gland early in life plays a role in the morphological development of the mammary gland during puberty.

The Role of Dietary Measurement Error in Investigating the Hypothesized Link Between Dietary Fat Intake and Breast Cancer—A Story with Twists and Turns

2008 ◽  
Vol 26 (1) ◽  
pp. 68-73 ◽  
Author(s):  
Anne C. M. Thiébaut ◽  
Victor Kipnis ◽  
Arthur Schatzkin ◽  
Laurence S. Freedman
Keyword(s):  
Breast Cancer ◽  
Measurement Error ◽  
Dietary Fat ◽  
Fat Intake ◽  
Dietary Fat Intake

scholarly journals Breast Cancer: Weighing the Evidence for a Promoting Role of Dietary Fat

1997 ◽  
Vol 89 (11) ◽  
pp. 766-775 ◽  
Author(s):  
E. L. Wynder ◽  
L. A. Cohen ◽  
J. E. Muscat ◽  
B. Winters ◽  
J. T. Dwyer ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Dietary Fat

scholarly journals Dietary Fatty Acids and Cancer

2019 ◽  
Vol 13 (1) ◽  
pp. 27-42
Author(s):  
Howard P. Glauert
Keyword(s):  
Breast Cancer ◽  
Dietary Fat ◽  
Intervention Studies ◽  
Experimental Studies ◽  
Epidemiological Studies ◽  
Dietary Fatty Acids ◽  
Health Initiative ◽  
Chemically Induced ◽  
Prostate Cancers

In this review, the influence of dietary fat on the development of cancer is discussed. In epidemiological studies, a relationship between dietary fat and breast cancer has been found in correlational studies, but prospective studies do not support a role for dietary fat. Prospective epidemiological studies examining the role of dietary fat in the development of colon, pancreatic, and prostate cancers have produced conflicting results. The Women’s Health Initiative intervention studies did not show any statistically significant effects of dietary fat on the development of either colon or breast cancer in women. In experimental studies, dietary fat generally enhances chemically-induced skin, liver, pancreatic, and mammary carcinogenesis, whereas conflicting results have been observed in colon carcinogenesis. Dietary fat appears to act primarily during the promotional stage of carcinogenesis in all of these models except the liver, where the effect of dietary fat is primarily on initiation.

The role of dietary fat in breast cancer

1997 ◽  
Vol 8 (1) ◽  
pp. 53-56 ◽  
Author(s):  
Kenneth K. Carroll
Keyword(s):  
Breast Cancer ◽  
Dietary Fat
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