Forward Engineering for New Databases

2018 ◽  
pp. 61-86
Author(s):  
Holger Schwichtenberg
Keyword(s):  
Forward Engineering

scholarly journals Control Reconfiguration for Improved Performance via Reverse-engineering and Forward-engineering

2020 ◽  
Vol 53 (2) ◽  
pp. 4688-4694
Author(s):  
Han Shu ◽  
Xuan Zhang ◽  
Na Li ◽  
Antonis Papachristodoulou
Keyword(s):  
Reverse Engineering ◽  
Forward Engineering ◽  
Improved Performance ◽  
Control Reconfiguration

scholarly journals A scientist engineer’s contribution to therapeutic discovery and development

2018 ◽  
Vol 243 (14) ◽  
pp. 1125-1132 ◽  
Author(s):  
Jennifer L Wilson
Keyword(s):  
Drug Development ◽  
Drug Effects ◽  
Deep Understanding ◽  
Empirical Models ◽  
Development Costs ◽  
Therapeutic Development ◽  
Forward Engineering ◽  
Tool Set ◽  
Complex Circuits ◽  
Cellular Components

An engineering perspective views cells as complex circuits that process inputs – drugs, environmental cues – to create complex outcomes – disease, growth, death – and this perspective has immense potential for drug development. Logical rules can describe the features of cells and reductionist approaches have exploited these rules for drug development. In contrast, the reductionist approach serially characterizes cellular components and develops a deep understanding of each component’s specific role. This approach underutilizes the full system of biomolecules relevant to disease pathology and drug effects. An engineering perspective provides the tools to understand and leverage the full extent of biological systems; applying both reverse and forward engineering, a strength of the engineering approach has demonstrated progress in advancing understanding of disease and drug mechanisms. Drug development lacks sufficient engineering specifications, or empirical models, of drug pharmacodynamic effects and future efforts to derive empirical models of drug effects will streamline this development. At this stage of progress, the scientist engineer is uniquely poised to solve problems in therapeutics related to modulating multiple diseases with a single or multiple therapeutic agents and identifying pharmacodynamics biomarkers with knowledge of drug pathways. This article underscores the value of these principles in an age where drug development costs are soaring and finding efficacious therapies is challenging. Impact statement Many untreated diseases are not monogenic and are instead caused by multiple genetic defects. Because of this complexity, computational, logical, and systems understanding will be essential to discovering novel therapies. The scientist engineer is uniquely disposed to use this type of understanding to advance therapeutic discovery. This work highlights benefits of the scientist engineer perspective and underscores the potential impact of these approaches for future therapeutic development. By framing the scientist engineer’s tool set and increasing awareness about this approach, this article stands to impact future therapeutic development efforts in an age of rising development costs and high drug attrition.

Recovering Business Process Models with Process Patterns

2013 ◽  
pp. 223-249
Author(s):  
Vitus S. W. Lam
Keyword(s):  
Business Process ◽  
Process Management ◽  
Control Flow ◽  
Process Models ◽  
Interaction Patterns ◽  
Workflow Patterns ◽  
Business Process Models ◽  
The Core ◽  
Forward Engineering ◽  
The Relationship

Originating from a pragmatic need to document strategies for modelling recurrent business scenarios, collections of workflow patterns have been proposed in the business process management community. The concrete applications of these workflow patterns in forward engineering have been extensively explored. Conversely, the core concern of business process archaeology is on recovering business process models from legacy systems utilizing reverse engineering methods. Little attention is given to the relationship between business process recovery and workflow patterns. This chapter aims to give a compact introduction to workflow control-flow patterns, workflow data patterns, workflow exception patterns, and service interaction patterns. In particular, the feasibility of combining workflow patterns with business process archaeology is examined by drawing on the research results of the MARBLE framework.

scholarly journals Reverse and Forward Engineering of Local Voltage Control in Distribution Networks

2020 ◽  
pp. 1-1
Author(s):  
Xinyang Zhou ◽  
Masoud Farivar ◽  
Zhiyuan Liu ◽  
Lijun Chen ◽  
Steven Low
Keyword(s):  
Voltage Control ◽  
Distribution Networks ◽  
Forward Engineering

Morphometric measurement and applicable feature analysis of sacral alar–iliac screw fixation using forward engineering

2019 ◽  
Vol 140 (2) ◽  
pp. 177-186 ◽  
Author(s):  
Fang Liu ◽  
Yang Yang ◽  
Chaolun Wen ◽  
Linya Guo ◽  
Aiping Wang ◽  
...  
Keyword(s):  
Screw Fixation ◽  
Feature Analysis ◽  
Morphometric Measurement ◽  
Iliac Screw ◽  
Forward Engineering

scholarly journals Chemical Effect on Wellbore Instability of Nahr Umr Shale

2013 ◽  
Vol 2013 ◽  
pp. 1-7 ◽  
Author(s):  
Baohua Yu ◽  
Chuanliang Yan ◽  
Zhen Nie
Keyword(s):  
Drilling Fluid ◽  
Ionic Concentration ◽  
Chemical Effect ◽  
Drilling Fluids ◽  
Collapse Pressure ◽  
Wellbore Instability ◽  
Sealing Capacity ◽  
Engineering Data ◽  
Forward Engineering ◽  
Rock Mechanical Properties

Wellbore instability is one of the major problems that hamper the drilling speed in Halfaya Oilfield. Comprehensive analysis of geological and engineering data indicates that Halfaya Oilfield features fractured shale in the Nahr Umr Formation. Complex accidents such as wellbore collapse and sticking emerged frequently in this formation. Tests and theoretical analysis revealed that wellbore instability in the Halfaya Oilfield was influenced by chemical effect of fractured shale and the formation water with high ionic concentration. The influence of three types of drilling fluids on the rock mechanical properties of Nahr Umr Shale is tested, and time-dependent collapse pressure is calculated. Finally, we put forward engineering countermeasures for safety drilling in Halfaya Oilfield and point out that increasing the ionic concentration and improving the sealing capacity of the drilling fluid are the way to keep the wellbore stable.

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