Methacrylate Oligomers with Pendant Isocyanate Groups as Tissue Adhesives

Letters to the Editors: Re: Reply to David Perez-Meza on tissue adhesives

International Society of Hair Restoration Surgery ◽

10.33589/21.5.0175 ◽

2011 ◽

Vol 21 (5) ◽

pp. 175-175

Author(s):

Luiz A.S. Pimentel

Keyword(s):

Tissue Adhesives

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The Use of Fibrin-based Tissue Adhesives for Breast in Reconstructive and Plastic Surgery

Current Topics in Medicinal Chemistry ◽

10.2174/1568026619666191112101448 ◽

2020 ◽

Vol 19 (32) ◽

pp. 2985-2990 ◽

Cited By ~ 1

Author(s):

Kuo Chen ◽

Mikhail Y. Sinelnikov ◽

Vladimir N. Nikolenko ◽

Igor V. Reshetov ◽

Yu Cao ◽

...

Keyword(s):

Quality Of Life ◽

Postoperative Complications ◽

Plastic Surgery ◽

Fibrin Glue ◽

Reconstructive Surgery ◽

Tissue Adhesives ◽

Tissue Adhesion ◽

Advanced Technologies ◽

Breast Plastic Surgery

Background: Breast plastic surgery is a rapidly evolving field of medicine. The modern view of surgical trends reflects the desire to minimize complications and introduce advanced technologies. These always will be priorities for surgeons. Reconstructive surgery, a branch of plastic surgery focusing on restoration of lost functional and aesthetic component, seeks to enhance psychological rehabilitation and improves the quality of life, as well as aesthetic recovery. Objective: This review addresses the action of fibrin agents and their effect on the quality of surgical hemostasis. Discussion and Conclusion: The fundamental goals for the surgeon are to perform a minimally traumatic intervention and to prevent any form of complication. Achieving complete hemostasis is an intraoperative necessity. Timely prevention of bleeding and hemorrhagic phenomena can affect not only the outcome of the operation, but also the incidence of postoperative complications. Topics include the integrity of microvascular anastomoses, tissue adhesion, and the incidence of seromas and hematomas associated with fibrin glue usage. The literature on fibrin adhesives with respect to prevention of postoperative complications, and the effectiveness with active drainage also are analyzed.

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Assessment of Commercial Off-the-Shelf Tissue Adhesives for Sealing Military-Relevant Corneal Perforation Injuries

Military Medicine ◽

10.1093/milmed/usab184 ◽

2021 ◽

Author(s):

Eric J Snider ◽

Lauren E Cornell ◽

Brandon M Gross ◽

David O Zamora ◽

Emily N Boice

Keyword(s):

Intraocular Pressure ◽

High Speed ◽

Anterior Segment ◽

Ocular Tissue ◽

Corneal Tissue ◽

Corneal Perforation ◽

Tissue Adhesives ◽

Open Globe ◽

Wide Range ◽

Commercial Off The Shelf

ABSTRACT Introduction Open-globe ocular injuries have increased in frequency in recent combat operations due to increased use of explosive weaponry. Unfortunately, open-globe injuries have one of the worst visual outcomes for the injured warfighter, often resulting in permanent loss of vision. To improve visual recovery, injuries need to be stabilized quickly following trauma, in order to restore intraocular pressure and create a watertight seal. Here, we assess four off-the-shelf (OTS), commercially available tissue adhesives for their ability to seal military-relevant corneal perforation injuries (CPIs). Materials and Methods Adhesives were assessed using an anterior segment inflation platform and a previously developed high-speed benchtop corneal puncture model, to create injuries in porcine eyes. After injury, adhesives were applied and injury stabilization was assessed by measuring outflow rate, ocular compliance, and burst pressure, followed by histological analysis. Results Tegaderm dressings and Dermabond skin adhesive most successfully sealed injuries in preliminary testing. Across a range of injury sizes and shapes, Tegaderm performed well in smaller injury sizes, less than 2 mm in diameter, but inadequately sealed large or complex injuries. Dermabond created a watertight seal capable of maintaining ocular tissue at physiological intraocular pressure for almost all injury shapes and sizes. However, application of the adhesive was inconsistent. Histologically, after removal of the Dermabond skin adhesive, the corneal epithelium was removed and oftentimes the epithelium surface penetrated into the wound and was adhered to inner stromal tissue. Conclusions Dermabond can stabilize a wide range of CPIs; however, application is variable, which may adversely impact the corneal tissue. Without addressing these limitations, no OTS adhesive tested herein can be directly translated to CPIs. This highlights the need for development of a biomaterial product to stabilize these injuries without causing ocular damage upon removal, thus improving the poor vision prognosis for the injured warfighter.

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